Investigation of the brain and cell injury responsible for depression with immune-challenged animal model

• Project/Area Number: 22390226
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: KANBA Shigenobu 九州大学, 医学研究院, 教授 (50195187)
• Co-Investigator(Renkei-kenkyūsha): ONITSUKA Toshiaki 九州大学, 病院, 講師 (00398059) ; MOTOMURA Keisuke 九州大学, 病院, 助教 (60432944) ; MIURA Tomofumi 九州大学, 大学院・医学研究院, 助 (90404053)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2010: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: うつ病 / サイトカイン / 精神疾患 / 神経科学 / 脳 / 動物モデル

Research Abstract

By systemic injection of bacterial endotoxin into mice, we generated an animal model of depression which showed depressive behavior and microglial activation in the regions around the periventricular organs. In another experiment on forced swim test, some

Research Products

• [Journal Article] Are microglia minding us? Digging up the unconscious mind-brain relationship from a neuropsychoanalytic approach (2013)
  • Author(s): Kato TA, Kanba S
  • Journal Title: Front Hum Neurosci Volume: 13 Pages: 13-13
  • DOI: 10.3389/fnhum.2013.00013
  • Peer Reviewed
• [Journal Article] Early and late stages of visual processing in individuals in prodromal state and first episode schizophrenia: An ERP study (2013)
  • Author(s): Oribe N, Hirano Y, Kanba S, Del Re EC, Seidman LJ, Mesholam-Gately R, Spencer KM. McCarley RW, Niznikiewicz MA
  • Journal Title: Schizophr Res. Volume: 146 Issue: 1-3 Pages: 95-102
  • DOI: 10.1016/j.schres.2013.01.015
• [Journal Article] Mechanism forretardation of amyloid fibril formation by sugars in Va,6 protein. (2013)
  • Author(s): Abe M, Abe Y, Ohkuri T, Mishima T, Monji A, Kanba S, Ueda T.
  • Journal Title: Protein Sci. Volume: 22 Issue: 4 Pages: 467-474
  • DOI: 10.1002/pro.2228
  • Peer Reviewed
• [Journal Article] Lost in translation: confusion about depression andantidepressant therapy in Japan (2013)
  • Author(s): Motomura K, Kanba S
  • Journal Title: Psychiatry Clin Neurosci. Volume: 67(1) Issue: 1 Pages: 1-2
  • DOI: 10.1111/pcn.12011
• [Journal Article] A population-specific uncommon variant in GRIN3A associated with schizophrenia (2013)
  • Author(s): Takata A, Iwayama Y, Fukuo Y, Ikeda M, Okochi T, Maekawa M, Toyota T, YamadaK, Hattori E, Ohnishi T, Toyoshima M, Ujike H, Inada T, Kunugi H, Ozaki N, Nanko S, Nakamura K, Mori N, Kanba S, Iwata N, Kato T, Yoshikawa T.
  • Journal Title: Biol Psychiatry. Volume: 73 Issue: 6 Pages: 532
  • DOI: 10.1016/j.biopsych.2012.10.024
  • URL: https://pure.teikyo.jp/en/publications/a636122a-abb5-4dec-88db-1fdadc83e4ec
  • Peer Reviewed
• [Journal Article] Minocycline modulates human social decision-making: possible impact of microglia on personality-oriented social behaviors. (2012)
  • Author(s): Kato TA, Watabe M, Tsuboi S, Ishikawa K, Hashiya K, Monji A, Utsurni H, Kanba S.
  • Journal Title: PLoS One Volume: 7(7)
• [Journal Article] Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients. (2012)
  • Author(s): Oda Y, *Onitsuka T, Tsuchimoto R, Hirano S, Oribe N, Ueno T, Hirano Y, Nakamura I, Miura T, Kanba S.
  • Journal Title: PLoS One Volume: 7(7)
• [Journal Article] Altered face inversion effect and association betweenface N170 reduction and social dysfunction in patients with schizophrenia. (2012)
  • Author(s): Tsunoda T,_Kanba S, Ueno T, Hirano Y, Hirano S, Maekawa T, *Onitsuka T.
  • Journal Title: Clin Neurophysiol. Volume: 123(9) Pages: 1762-8
• [Journal Article] Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction? (2012)
  • Author(s): Watabe M, Kato TA, Monji A, Horikawa H, Kanba S.
  • Journal Title: Psychopharmacology (Berl). Volume: 220(3) Pages: 551-7
• [Journal Article] Minocycline modulates human social decision-making: possible impact of microglia on personality-oriented social behaviors. (2012)
  • Author(s): kato TA
  • Journal Title: PLoS One Volume: 7(7):
  • Peer Reviewed
• [Journal Article] Gamma band neural synchronization deficits for auditory steady state responses in bipolar disorder patients (2012)
  • Author(s): Oda Y
  • Journal Title: PLoS One Volume: 7(7):
  • Peer Reviewed
• [Journal Article] Altered face inversion effect and association between face N170 reduction and social dysfunction in patients with schizophrenia. (2012)
  • Author(s): Tsunoda T
  • Journal Title: Clin Neurophysiol Volume: 123(9 Pages: 1762-8
  • Peer Reviewed
• [Journal Article] Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction? (2012)
  • Author(s): Watabe M
  • Journal Title: Psychopharmacology (Berl) Volume: 220(3): Pages: 551-7
  • Peer Reviewed
• [Journal Article] Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia. (2011)
  • Author(s): Kato TA, Monji A, Yasukawa K, Mizouchi Y, Horikawa H, Seki Y, Hashioka S, Han YH, Kasai M, Sonoda N, Hirata E, Maeda Y, Inoguchi T, Utsumi H, *Kanba S
  • Journal Title: Schizophr Res Volume: 29(2-3) Pages: 172-82
• [Journal Article] Reduced high and low frequency gamma synchronization in patients with chronic schizophrenia (2011)
  • Author(s): Tsuchimoto R, Kanba S, Hirano S, Oribe N, Ueno T, Hirano Y, Nakamura I, Oda Y, Miura T, *Onitsuka T.
  • Journal Title: Schizophr Res Volume: 33(1-3) Pages: 99-105
• [Journal Article] cAMP response element-binding protein (CREB) is required for epidermal growth factor (EGF)-induced cell proliferation and serum response element activation in neural stem cells isolated from the forebrain subventricular zone of adult mice (2011)
  • Author(s): Iguchi H, Mitsui T, Ishida M, Kanba S, Arita J
  • Journal Title: Endocr J Volume: 58(9) Pages: 747-59
  • NAID: 10029862663
  • Peer Reviewed
• [Journal Article] Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated micro glia in vitro : implication for antioxidative psychotropic actions via microglia (2011)
  • Author(s): Kato TA, Monji A, Yasukawa K, Mizoguchi Y, Horikawa H, Seki Y, Hashioka S, Han YH, Kasai M, Sonoda N, Hirata E, Maeda Y, Inoguchi T, Utsumi H, Kanba S
  • Journal Title: Schizophr Res Volume: 129 Pages: 172-182
  • Peer Reviewed
• [Journal Article] 精神疾患における脳内炎症免疫機構の意義-統合失調症のミクログリア仮説 (2011)
  • Author(s): 加藤隆弘, 門司晃, 神庭重信
  • Journal Title: 細胞工学 Volume: 30 Pages: 1046-1053
• [Journal Article] Possible role of BDNF-induced microglial intracellular Ca(2+) elevation in the pathophysiology of neuropsychiatric disorders (2011)
  • Author(s): Mizoguchi Y, Monji A, Kato TA, Horikawa H, Seki Y, Kasai M, Kanba S, Yamada S
  • Journal Title: Mini Rev Med Chem Volume: 11 Pages: 575-81
  • Peer Reviewed
• [Journal Article] Inhibitory effects of SSRIs on IFN-y induced microglial activation through the regulation of intracellular calcium (2010)
  • Author(s): Horikawa H, Kato TA, Mizoguchi Y, Monji A, Seki Y, Ohkuri T, Gotoh L, Yonaha M, Ueda T, Hashioka S, *Kanba S.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry. Volume: 34(7) Pages: 1306-16
• [Journal Article] Evidence for the binding of phosphate ion to the C -terminus region in Abl-40 using hereronuclear NMR analysis. (2010)
  • Author(s): Uchiyama M, Monj A, Kanemaru T, Abe Y, Ueda T.
  • Journal Title: Protein & Peptide Letters Volume: 17 Pages: 176-180
  • Peer Reviewed
• [Journal Article] Auditory Gating Deficit to Human Voices in Schizophrenia : a MEG study. (2010)
  • Author(s): Hirano S, Hirano Y, Maekawa T, Obayashi C, Oribe N, Monji A, Kasai K, Kanba S, Onitsuka T
  • Journal Title: Schizophrenia Research Volume: 117(1) Pages: 61-67
  • Peer Reviewed
• [Journal Article] Effects of His mutations on the fibrillation of amyloidogenic Vlambda6 protein Wil under acidic and physiological conditions. (2010)
  • Author(s): Mishima T, Ohkuri T, Monji A, Kanemaru T, Abe Y, Ueda T
  • Journal Title: Biochemical & Biophysical Research Communications Volume: 391(1) Pages: 615-620
  • Peer Reviewed
• [Journal Article] Successful treatment of chronic urticaria with a Japanese herbal medicine, yokukansan. (2010)
  • Author(s): Kato S, Kato TA, Nishie H, Nishima S, Iwanaga T, Monji A, Nakano M, Takeshita H, Furue M
  • Journal Title: Journal of Dermatology Volume: 37 Pages: 1-2
  • Peer Reviewed
• [Journal Article] Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium. (2010)
  • Author(s): Horikawa H, Kato T, Mizoguchi Y, Monji A, Seki Y, Ohkuri T, Gotoh L, Yonaha Y, Ueda T, Hashioka S, Kanba S.
  • Journal Title: Progress in Neurosychopharmacology & Biological psychiatry Volume: 34(7) Pages: 1306-1316
  • Peer Reviewed
• [Journal Article] 精神疾患における神経免疫仮説 (2010)
  • Author(s): 門司晃
  • Journal Title: 実験医学 Volume: 28(14) Pages: 2218-2223
  • Peer Reviewed
• [Presentation] Depression In Asia, symposium Characteristics of depression in young Japanese. (2012)
  • Author(s): Kanba S
  • Organizer: 15th Pacific Rim College of Psychiatrists Scientific Meeting 2012
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2012-10-27
• [Presentation] Czech Plenary lecture Neuroinflammatory hypothesis of schizophrenia (2012)
  • Author(s): Kanba S
  • Organizer: World Psychiatric Association International Congress 2012 Prague
  • Year and Date: 2012-10-20
• [Presentation] Genomic and clinical phenotype considerations in evaluating antidepressant-induced mania to individualize the treatment for bipolar depression (2012)
  • Author(s): Fry M A and Kanba S
  • Organizer: symposium chair 5th Biennial Conference of the International Society For Bipolar Disorders
  • Place of Presentation: Instanbul, Turkey
• [Presentation] Neuroinflammatory hypothesis of schizophrenia (2012)
  • Author(s): Kanba S
  • Organizer: Taiwanese Society of Biological Psychiatry and Neuropsychopharmacology 2012
• [Presentation] Depression in Asia (2011)
  • Author(s): Kanba S
  • Organizer: World Psychiatric Association Regional
  • Place of Presentation: Taipei, Taiwan(招待講演)
  • Year and Date: 2011-11-03
• [Presentation] Systemic lipopolysaccharaide induces prolonged microglial activation in specific brain regions in mice. (2011)
  • Author(s): Ohashi A et al.
  • Organizer: Asian College of Neuropyschopharamacology.
  • Place of Presentation: Asian College of Neuropyschopharamacology.
  • Year and Date: 2011-09-23
• [Presentation] Systemic lopopolysaccharaide induces prolonged microglial activation in specific brain regions in mice (2011)
  • Author(s): Ohashi A, et al
  • Organizer: Asian College of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-09-23
• [Presentation] Neuroinflammatory pathology in schizophrenia and depression: From diagnosisito treatment. (2011)
  • Author(s): Kanba, S and Muller N
  • Organizer: 10th WFSBP Prague, symposium chairman
• [Presentation] Antidepressant effects in the forced swim test. (2011)
  • Author(s): Yanagida S et al.
  • Organizer: 8th IBRO World Congress of neuroscience
  • Place of Presentation: Florence, Italy.
• [Presentation] WPA regional symposium in Kaoshung (2011)
  • Author(s): Kanba S
  • Organizer: symposium speaker Depression in Asia
• [Presentation] Antidepressant effects in the forced swim test (2011)
  • Author(s): Yanagida S, et al
  • Organizer: 8^<th> IBRO World Congress of Neuroscience
  • Place of Presentation: Florence, Italy
• [Presentation] Controversies and New Treatment of Diabetes (2010)
  • Author(s): Kanba, S
  • Organizer: 8th International Diabetes Federation; Western Pacific Region Congress Prevalence of depression in metabolic syndrome: the Hisayama Study
  • Place of Presentation: Busan
  • Year and Date: 2010-10-18
• [Presentation] Antidepressant-like effect of CRF1 receptor antagonist on the forced swim test in mice. (2010)
  • Author(s): Ohashi, et al.
  • Organizer: 第32回日本生物学的精神医学会
  • Place of Presentation: 北九州市
  • Year and Date: 2010-10-09
• [Presentation] Innovations in themanagement of bipolar disorder (2010)
  • Author(s): Kanba, S
  • Organizer: CINP Hong Kong, symposium
• [Presentation] Antidepressant-like effect of CRF1 receptor antagonist on the forced swim test in mice. (2010)
  • Author(s): Ohashi, et al.
  • Organizer: XXVII CINP Congress, 2010 World Congress
  • Place of Presentation: Hong Kong
• [Presentation] Neuroinflammatory hypothesis of schizophrenia
  • Author(s): Kanba S
  • Organizer: World Psychiatric Association International Congress
  • Place of Presentation: Prague
  • Invited
• [Presentation] Characteristics of depression in young Japanese
  • Author(s): Kanba S
  • Organizer: 15th Pacific Rim College of Psychiatrists Scientific Meeting
  • Place of Presentation: Seoul
• [Book] 成人精神医療からみた創発OCDの特徴子どもの強迫性障害:診断・治療ガイドライン (2012)
  • Author(s): 樋口麻衣子、中尾智博、神庭重信、斎藤万比古、金生由紀子
  • Publisher: 星和書店
• [Book] 子どもの強迫性障害：診断・治療ガイドライン (2012)
  • Author(s): 樋口麻衣子
  • Publisher: 星和書店
• [Book] 現代精神医学事典 (2011)
  • Author(s): 加藤敏、神庭重信、中谷陽二、武田雅俊、狩野力八郎、市川宏伸
  • Publisher: 弘文堂
• [Book] 「うつ」の構造 (2011)
  • Author(s): 神庭重信、内海健
  • Publisher: 弘文堂
• [Book] 「うつ」の構造 (2011)
  • Author(s): 神庭重信, 内海健編著
  • Total Pages: 214
  • Publisher: 弘文堂
• [Book] 脳科学エッセンシャル、精神疾患の生物学的理解のために (2010)
  • Author(s): 神庭重信、加藤忠史
  • Publisher: 中山書店
• [Book] 専門医のための精神科リュミエール16「脳科学エッセンシャル:精神疾患の生物学的理解のために」(本村啓介分担執筆) (2010)
  • Author(s): 神庭重信, 加藤忠史(eds)
  • Total Pages: 53
  • Publisher: 中山書店
• [Book] 専門医のための精神科リュミエール16「脳科学エッセンシャル:精神疾患の生物学的理解のために」(門司晃分担執筆) (2010)
  • Author(s): 神庭重信, 加藤忠史(eds)
  • Total Pages: 2
  • Publisher: 中山書店
• [Remarks]
  • URL: http://www.med.kyushu-u.ac.jp/psychiatry/