Application of focal brain cooling for intractable epilepsy

• Project/Area Number: 22390276
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Yamaguchi University
• Principal Investigator: SUZUKI Michiyasu 山口大学, 大学院・医学系研究科, 教授 (80196873)
• Co-Investigator(Kenkyū-buntansha): OWADA Yuji 山口大学, 大学院・医学系研究科, 教授 (20292211) ; FUJII Masami 山口大学, 医学部附属病院, 准教授 (90181320) ; NOMURA Sadahiro 山口大学, 医学部附属病院, 講師 (20343296)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2010: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
• Keywords: epilepsy / focal brain cooling / brain cooling / device / glutamate / cerebral blood flow / metabolism / 機能脳神経外科学 / 脳低温 / 脳低温療法

Research Abstract

Safeness of focal brain cooling (FBC) for intractable epilepsy was verified. A rat epilepsy model was treated by the FBC. The optimal temperature to interrupt seizure without deteriorating neuronal function was 15 ℃. The FBC was applied at epilepsy surgery in human. Increased levels of glutamate and lactate reduced at 15 ℃. The FBC effectively inhibit neuronal excitotoxicity and anaerobic metabolism. Newly developed cooling device was successfully applied to cats and monkeys.

Research Products

• [Journal Article] Neuroprotective effects of focal brain cooling on photochemically-induced cerebral infarction in rats: analysis from a neurophysiological perspective. (2013)
  • Author(s): Yeting He
  • Journal Title: Brain Res Volume: 1497 Pages: 53-60
  • DOI: 10.1016/j.brainres.2012.11.041
  • Peer Reviewed
• [Journal Article] Insular psammomatous meningioma presenting intractable complex partial seizures. (2012)
  • Author(s): Imoto H, Fujii M , Nomura S , Suzuki M, 他
  • Journal Title: No Shinkei Geka Volume: 40(9) Pages: 799-804
  • Peer Reviewed
• [Journal Article] Focal brain cooling terminates the faster frequency components of epileptic discharges induced by penicillin G in anesthetized rats (2012)
  • Author(s): Kida H, Fujii M , Nomura S , Suzuki M , 他
  • Journal Title: Clin Neurophysiol Volume: 123(9) Pages: 1708-13
  • Peer Reviewed
• [Journal Article] Cooling of the epileptic focus suppresses seizures with minimal influence on neurologic functions (2012)
  • Author(s): Fujii M , Nomura S , Owada Y, Suzuki M , 他
  • Journal Title: Epilepsia Volume: 53(3) Pages: 485-93
  • Peer Reviewed
• [Journal Article] Intra-operative monitoring of lower extremity motor-evoked potentials by direct cortical stimulation (2012)
  • Author(s): Maruta Y, Fujii M , Nomura S , Suzuki M, 他
  • Journal Title: Clin Neurophysiol Volume: 123(6) Pages: 1248-54
  • Peer Reviewed
• [Journal Article] Focal brain cooling terminates the faster frequency components of epileptic discharges induced by penicillin G in anesthetized rats. (2012)
  • Author(s): Hiroyuki Kida
  • Journal Title: Clin Neurophysiol Volume: 123 Issue: 9 Pages: 1708-1713
  • DOI: 10.1016/j.clinph.2012.02.074
  • Peer Reviewed
• [Journal Article] Intra-operative monitoring of lower extremity motor-evoked potentials by direct cortical stimulation (2012)
  • Author(s): Maruta Y, Suzuki M, et.al
  • Journal Title: Clin Neurophysiol Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Significance of differences between brain temperature and core temperature (delta T) during mild hypothermia in patients with diffuse axonal injury. (2011)
  • Author(s): Suehiro E, Nomura S , Fujii M, Suzuki M , 他
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 51(8) Pages: 551-5
  • NAID: 10029338156
  • Peer Reviewed
• [Journal Article] Cooling of the epileptic focus suppresses seizures with minimal influence on neurologic functions (2011)
  • Author(s): Fujii M, et al
  • Journal Title: Epilepsia Volume: 53 Issue: 3 Pages: 489-493
  • DOI: 10.1111/j.1528-1167.2011.03388.x
  • Peer Reviewed
• [Journal Article] Significance of differences between brain temperature and core temperature (delta T) during mild hypothermia in patients with diffuse axonal injury (2011)
  • Author(s): Suehiro E, Suzuki M, et al
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 51 Pages: 551-555
  • NAID: 10029338156
  • Peer Reviewed
• [Journal Article] 脳内埋め込み型大脳局所冷却装置によるてんかん治療法の開発 (2011)
  • Author(s): 藤井正美、鈴木倫保, 他
  • Journal Title: てんかん治療研究振興財団研究年報 Volume: 22 Pages: 91-98
• [Journal Article] Application of focal cerebral cooling for the treatment of intractable epilepsy (2010)
  • Author(s): Fujii M , Nomura S , Suzuki M , 他
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 50(9) Pages: 839-44
  • NAID: 10030693779
  • Peer Reviewed
• [Journal Article] An implantable, focal brain cooling device suppresses nociceptive pain in rats (2010)
  • Author(s): Fujioka H, Fujii M , Nomura S, Suzuki M, 他
  • Journal Title: Neurosci Res Volume: 66(4) Pages: 402-5
  • Peer Reviewed
• [Journal Article] Epileptiform discharges and neuronal plasticity in the acute peri-infarct cortex of rats. (2010)
  • Author(s): Fujioka H, Fujii M , Nomura S, Suzuki M, 他
  • Journal Title: Neurol Res Volume: 32(6) Pages: 666-9
  • Peer Reviewed
• [Journal Article] Application of focal cerebral cooling for the treatment of intractable epilepsy. (2010)
  • Author(s): Fujii M
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 50 Pages: 839-844
  • NAID: 10030693779
  • Peer Reviewed
• [Journal Article] An implantable, focal brain cooling device suppresses nociceptive pain in rats. (2010)
  • Author(s): Fujioka H
  • Journal Title: Neurosci Res Volume: 66 Pages: 402-405
  • Peer Reviewed
• [Journal Article] Epileptiform discharges and neuronal plasticity in the acute peri-infarct cortex of rats. (2010)
  • Author(s): Fujioka H
  • Journal Title: Neurol Res Volume: 32 Pages: 666-669
  • Peer Reviewed
• [Presentation] Local Brain Hypothermia Suppresses Perifocal Epileptiform Discharges Induced By Focal Cerebral Ischemia In Rats (2012)
  • Author(s): He Y, Suzuki M, et al
  • Organizer: 66th Annual Meeting and 4th Biennial North American Epilepsy Congresss
  • Place of Presentation: San Diego, USA
• [Presentation] Challenges and Opportunities for Development of a Focal Cooling Device for Intractable Epilepsy (2012)
  • Author(s): Inoue T, Suzuki M, et al
  • Organizer: KEC 2012
  • Place of Presentation: Seoul, Korea
• [Presentation] Challenges and Opportunities for Development of a Focal Cooling Device for Intractable Epilepsy (2012)
  • Author(s): Takao Inoue
  • Organizer: Korean Epilepsy Congress 2012
  • Place of Presentation: Seoul (Korea)
  • Invited
• [Presentation] 温度制御を用いた神経疾患治療法の開発 -Thermal neuromodulationの提唱- (2012)
  • Author(s): 藤井正美
  • Organizer: 第20回九州・山口機能神経外科セミナー
  • Place of Presentation: 福岡 (レイクサイドホテル久山)
  • Invited
• [Presentation] 機能神経外科の新たなアプローチ：Thermal neuromodulation (2012)
  • Author(s): 藤井正美
  • Organizer: 日本脳神経外科学会 第71回学術総会
  • Place of Presentation: 大阪 (大阪国際会議場)
• [Presentation] Local Brain Hypothermia Suppresses Perifocal Epileptiform Discharges Induced By Focal Cerebral Ischemia In Rats (2012)
  • Author(s): Yeting He
  • Organizer: 66th Annual Meeting and 4th Biennial North American Epilepsy Congresss
  • Place of Presentation: San Diego (USA)
• [Presentation] 局所脳冷却を用いた難治性てんかん治療装置の開発と臨床応用の実現に向けた医工連携 (2012)
  • Author(s): 藤井正美、鈴木倫保, 他
  • Organizer: 日本てんかん外科学会
  • Place of Presentation: 東京ステーションコンファレンス、東京(シンポジウム)
• [Presentation] 局所脳冷却によるてんかん発作抑制のための至適冷却温度についての検討 (2012)
  • Author(s): 井上貴雄、鈴木倫保, 他
  • Organizer: 日本てんかん外科学会
  • Place of Presentation: 東京ステーションコンファレンス、東京(シンポジウム)
• [Presentation] 脳冷却プローブを用いた術中脳機能マッピング法の確立 (2011)
  • Author(s): 藤井正美、鈴木倫保, 他
  • Organizer: 第9回日本Awake Surgery研究会
  • Place of Presentation: 日石横浜ホール、横浜市
  • Year and Date: 2011-09-08
• [Presentation] Cooling of the epileptic focus suppresses seizures with minimal infleuence on neurological functions (2011)
  • Author(s): Fujii M, et al
  • Organizer: 65th AES
  • Place of Presentation: Baltimore, USA
• [Presentation] Development of a Focal Cerebral Cooling System for the Treatment of Intractable Epilepsy (2011)
  • Author(s): Inoue T, Suzuki M, et al
  • Organizer: IEEE SMC
  • Place of Presentation: Alaska Anchorage, USA
• [Presentation] Alterative treatment of intractable epilepsy with focal brain cooling -A review of our past studies (2011)
  • Author(s): Fujii M, et al
  • Organizer: IEEE SMC
  • Place of Presentation: Alaska Anchorage, USA
• [Presentation] The effect of focal brain cooling on epileptic discharges in rats Frequency analysis electroencephalogram (2011)
  • Author(s): Kida H, Suzuki M, et al
  • Organizer: IEEE SMC
  • Place of Presentation: Alaska Anchorage, USA
• [Presentation] Minimally-invasive ECoG recording using the novel subdural electrodes manipulated by a shape memory alloy guidewire (2011)
  • Author(s): Yamakawa T, Suzuki M, et al
  • Organizer: 29th IEC
  • Place of Presentation: Rome, Itary
• [Presentation] Inhibitory effects of focal brain cooling for motor cortical seizures in cats and nonhuman primates (2011)
  • Author(s): Inoue T, Suzuki M, et al
  • Organizer: 29th IE
  • Place of Presentation: Rome, Itary
• [Presentation] Alterative treatment of intractable epilepsy with focal brain cooling (2011)
  • Author(s): Fujii M, et al
  • Organizer: 29th IE
  • Place of Presentation: Rome, Itary
• [Presentation] Alternative treatment of intractable epilepsy with focal brain cooling -A review of our past studies- (2011)
  • Author(s): Fujii M, et al
  • Organizer: The 8th AASSFN
  • Place of Presentation: Jeju, Korea
• [Presentation] Application of focal brain cooling for the treatment of intractable epilepsy (2011)
  • Author(s): Fujii M, et al
  • Organizer: 2nd Annual Congress of Neuro Talk
  • Place of Presentation: Dalian, China
• [Presentation] Cooling of the Epileptic Focus Suppresses Seizures with Minimal Influence on Neurological Functions (2011)
  • Author(s): Fujii M, Inoue T, Suzuki M, et al
  • Organizer: American Epilepsy Society, Annual Meeting 2011
  • Place of Presentation: Baltimore, USA
• [Presentation] 局所脳冷却を用いた術中脳機能マッピング法の確立 (2011)
  • Author(s): 藤井正美、鈴木倫保, 他
  • Organizer: 第41回日本臨床神経生理学会学術大会
  • Place of Presentation: グランシップ、静岡市
• [Presentation] てんかん外科のこれまでの歩みと新たな展開-低浸襲治療法の開発- (2011)
  • Author(s): 藤井正美、鈴木倫保, 他
  • Organizer: 日本脳神経外科学会第70回学術総会
  • Place of Presentation: パシフィコ横浜、横浜市(シンポジウム)
• [Presentation] Alterative treatment of intractable epilepsy with focal brain cooling-A review of our past atudies- (2011)
  • Author(s): Fujii M, Inoue T, Suzuki M, et al
  • Organizer: IEEE SMC 2011
  • Place of Presentation: Anchorage (Alaska), USA
• [Presentation] Development of a Focal Cerebral Cooling System for the Treatment of Intractable Epilepsy (2011)
  • Author(s): Takao Inoue, Michiyasu Suzuki, et.al
  • Organizer: IEEE SMC 2011
  • Place of Presentation: Anchorage(Alaska), USA
• [Presentation] The effect of focal brain cooling on epileptic discharges in rats-Frequency analysis of electroencephalography- (2011)
  • Author(s): Kida H, Suzuki M, et al
  • Organizer: IEEE SMC 2011
  • Place of Presentation: Anchorage (Alaska), USA
• [Presentation] Inhibitory effects of focal brain cooling for motor cortical seizures in cats and nonhuman primates (2011)
  • Author(s): Inoue T, Suzuki M, et al
  • Organizer: 29th International Epilepsy Congress
  • Place of Presentation: Rome, Italy
• [Presentation] Alterative treatment of intractable epilepsy with focal brain cooling (2011)
  • Author(s): Fujii M, Suzuki M, et al
  • Organizer: 29th International Epilepsy Congress
  • Place of Presentation: Rome, Italy
• [Presentation] Identification of epileptic focus with multi-channel near-infrared spectroscopic topography (optic topography) (2011)
  • Author(s): Maruta Y, Suzuki M, et al
  • Organizer: 29th International Epilepsy Congress
  • Place of Presentation: Rome, Italy
• [Presentation] Application of focal brain cooling for the treatment of intractable epilepsy (2011)
  • Author(s): Masami Fujii, Michiyasu Suzuki, et al
  • Organizer: BITs 2nd Annual Congress of Neuro Talk-2011
  • Place of Presentation: Dalian, China
• [Presentation] Alternative treatment of intractable epilepsy with focal brain cooling -A review of our past studies- (2011)
  • Author(s): Masami Fujii, Michiyasu Suzuki, et al
  • Organizer: The 8th Scientific Meeting for the Asian Australasian Society of Stereotactic & Functional Neurosurgery
  • Place of Presentation: Jeju, Korea
• [Presentation] 術中脳機能マッピング用局所脳冷却プローブの開発 (2011)
  • Author(s): 藤井正美、鈴木倫保, 他
  • Organizer: 第20回脳神経外科手術と機器学会(CNTT)
  • Place of Presentation: あわぎんホール、徳島市
• [Presentation] 温度を用いた中枢神経疾患治療法 (2010)
  • Author(s): 鈴木倫保
  • Organizer: 第49回日本定位・機能神経外科学会
  • Place of Presentation: 大阪市,千里ライフサイエンスセンター
  • Year and Date: 2010-01-22
• [Presentation] 埋め込み型脳局所冷却デバイスによるeloquent cortexに焦点を有するてんかん部分発作の抑制 (2010)
  • Author(s): 鈴木倫保
  • Organizer: 第33回日本てんかん外科学会
  • Place of Presentation: 大阪市,千里ライフサイエンスセンター
  • Year and Date: 2010-01-22
• [Presentation] Application of focal cerebral cooling for the treatment of intractable epilepsy: An overview of past studies (2010)
  • Author(s): Fujii M
  • Organizer: 64th AES
  • Place of Presentation: San Antonio, USA
• [Presentation] An implantable, focal brain cooling device for epilepsy therapy: An animal and clinical investigation (2010)
  • Author(s): Fujioka H, Suzuki M, et al
  • Organizer: 29th ICCN
  • Place of Presentation: Kobe Convention Center, Kobe
• [Presentation] Coupling of cerebral blood flow and metabolism during focal hypothermia (2010)
  • Author(s): Fujioka H, Suzuki M, et al
  • Organizer: 8th Asian & Oceanian Epilepsy Congress
  • Place of Presentation: Melbourne, Australia
• [Presentation] Effect of Focal Brain Cooling On Epileptiform Discharges in Rat (2010)
  • Author(s): Fujii M, et al
  • Organizer: WAC
  • Place of Presentation: Kobe Convention Center, Kobe
• [Presentation] Focal Brain Cooling for the Treatment of Epilepsy: Laboratory and Clinical Investigation (2010)
  • Author(s): Fujioka H, Suzuki M, et al
  • Organizer: WAC
  • Place of Presentation: Kobe Convention Center, Kobe
• [Presentation] てんかん治療における地域連携・病診連携、山口県てんかん診療ネットワーク構築について
  • Author(s): 藤井正美
  • Organizer: 日医生涯教育協力講座
  • Place of Presentation: 山口 (山口県健康づくりセンター)
  • Invited
• [Patent(Industrial Property Rights)] 大脳局所冷却プローブ及び脳機能マッピング装置 (2011)
  • Inventor(s): 鈴木倫保、藤井正美、野村貞宏
  • Industrial Property Rights Holder: 山口大学
  • Filing Date: 2011-03-25
  • Overseas