Application of focal brain cooling for intractable epilepsy
Project/Area Number |
22390276
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cerebral neurosurgery
|
Research Institution | Yamaguchi University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
OWADA Yuji 山口大学, 大学院・医学系研究科, 教授 (20292211)
FUJII Masami 山口大学, 医学部附属病院, 准教授 (90181320)
NOMURA Sadahiro 山口大学, 医学部附属病院, 講師 (20343296)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2010: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
|
Keywords | epilepsy / focal brain cooling / brain cooling / device / glutamate / cerebral blood flow / metabolism / 機能脳神経外科学 / 脳低温 / 脳低温療法 |
Research Abstract |
Safeness of focal brain cooling (FBC) for intractable epilepsy was verified. A rat epilepsy model was treated by the FBC. The optimal temperature to interrupt seizure without deteriorating neuronal function was 15 ℃. The FBC was applied at epilepsy surgery in human. Increased levels of glutamate and lactate reduced at 15 ℃. The FBC effectively inhibit neuronal excitotoxicity and anaerobic metabolism. Newly developed cooling device was successfully applied to cats and monkeys.
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Report
(4 results)
Research Products
(56 results)