The significance of COX-2 expression and therapeutic application in malignant gliomas

• Project/Area Number: 22390279
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kyushu University
• Principal Investigator: YOSHIMOTO Koji 九州大学, 大学病院, 講師 (70444784)
• Co-Investigator(Kenkyū-buntansha): MIZOGUCHI Masahiro 九州大学, 大学病院, 講師 (50380621) ; AMANO Toshiyuki 九州大学, 大学病院, 助教 (70448413)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
• Keywords: 悪性神経膠腫 / COX-2 / mesenchymal / 悪性神経神経膠腫

Research Abstract

The expression level of COX-2 in glioma tissues positively correlated with tumor malignancy and mesenchymal marker expression. These results suggest that COX-2 induction is associated with the tumor characteristics such as invasion and angiogenesis. By contrast, COX-2 expression in glioma stem cells which grow in neurosheres is decreased or almost absent. Therefore, it can be concluded that COX-2 expression is not implicated in the proliferation and selfrenewal of glioma stem cells.

Research Products

• [Journal Article] Associations between microRNA expression and mesenchymal marker gene expression in glioblastoma (2012)
  • Author(s): Ma X, Yoshimoto K, Guan Y, Hata N, Mizoguchi M, Sagata N, Murata H, Kuga D, Amano T, Nakamizo A, Sasaki T
  • Journal Title: Neuro-Oncology Volume: 14(9) Pages: 1153-1162
• [Journal Article] Molecular biomarkers of glioblastoma: Current targets and clinical implications (2012)
  • Author(s): Yoshimoto K, Mizoguchi M, Hata N, Amano T, Nakamizo A, Sasaki T
  • Journal Title: Current Biomarker Findings Volume: 2 Pages: 63-76
• [Journal Article] Associations between microRNA expression and mesenchymal marker gene expression in glioblastoma (2012)
  • Author(s): Xinlong Ma
  • Journal Title: Neuro-Oncology Volume: 14 Issue: 9 Pages: 1153-1162
  • DOI: 10.1093/neuonc/nos145
  • Peer Reviewed
• [Journal Article] Molecular biomarkers of glioblastoma: current targets and clinical implications (2012)
  • Author(s): Koji Yoshimoto
  • Journal Title: Current Biomarker Findings Volume: 2 Pages: 63-76
  • DOI: 10.2147/cbf.s25590
  • Peer Reviewed
• [Journal Article] Expression of stem cell marker and receptor kinase genes in glioblastoma tissue quantified by real-time RT-PCR (2011)
  • Author(s): Koji Yoshimoto (first author)
  • Journal Title: Brain Tumor Pathology Volume: 28(4) Issue: 4 Pages: 291-296
  • DOI: 10.1007/s10014-011-0046-0
  • Peer Reviewed
• [Presentation] 膠芽腫におけるmesenchymalマーカーの発現とmicroRNAによる発現制御 (2012)
  • Author(s): 吉本幸司
  • Organizer: 第30回日本脳腫瘍病理学会
  • Place of Presentation: 広島
  • Year and Date: 2012-11-25
• [Presentation] Diagnostic significance of microRNA and gene expression in glioma patietns (2012)
  • Author(s): 吉本幸司
  • Organizer: 第4回国際脳腫瘍病理シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2012-05-25
• [Presentation] Primary GBM vs secondary GBMーmRNA、microRNA発現の相違ー (2012)
  • Author(s): 吉本幸司
  • Organizer: 第13回日本分子脳神経外科学会
  • Place of Presentation: 熊本
• [Presentation] 膠芽腫におけるmesenchymal マーカーの発現とmicroRNAによる発現制御 (2012)
  • Author(s): 吉本幸司
  • Organizer: 第30回日本脳腫瘍学会
  • Place of Presentation: 広島
• [Presentation] Diagnostic significance of microRNA and gene expression in glioma patients. (2012)
  • Author(s): Koji Yoshimoto
  • Organizer: 第4回国際脳腫瘍病理シンポジウム
  • Place of Presentation: 名古屋
• [Presentation] 脳腫瘍幹細胞様細胞におけるproneural, mesenchymal遺伝子群の発現と変化 (2011)
  • Author(s): 吉本幸司
  • Organizer: 第29回日本脳腫瘍学会学術総会
  • Place of Presentation: 岐阜
  • Year and Date: 2011-11-27
• [Presentation] 膠芽腫に対するDNA修復阻害薬を用いた分子標的療法の可能性 (2011)
  • Author(s): 吉本幸司
  • Organizer: 第70回日本脳神経外科学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-10-12
• [Presentation] 膠芽腫組織におけるDNA損傷応答関連分子発現の免疫組織学的評価 (2011)
  • Author(s): 吉本幸司
  • Organizer: 第29回日本脳腫瘍学会学術総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-20
• [Presentation] 無血清培地で長期培養したグリオーマの遺伝子解析 (2010)
  • Author(s): 吉本幸司
  • Organizer: 第28回日本脳腫瘍学会学術集会
  • Place of Presentation: 軽井沢
  • Year and Date: 2010-11-28