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Analysis of stemness regulators in brain cancer stem cells

Research Project

Project/Area Number 22390283
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKeio University

Principal Investigator

TODA Masahiro  慶應義塾大学, 医学部, 准教授 (20217508)

Co-Investigator(Renkei-kenkyūsha) UEDA Ryo  慶應義塾大学, 医学部, 共同研究員 (30317143)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywords脳腫瘍幹細胞 / グリオーマ / 増殖因子 / 未分化 / クローニング / 幹細胞
Research Abstract

To identify genes that are highly expressed in brain cancer stem cells (BCSC), we performed cDNA microarray analysis using isolated BCSCs, glioma cells and neural stem cells, and identified a new BCSC antigen, KLRC2. To identify genes that regulate the st

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (78 results)

All 2013 2012 2011 2010 Other

All Journal Article (26 results) (of which Peer Reviewed: 21 results) Presentation (46 results) (of which Invited: 1 results) Book (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Infratentorial low-grade oligoastrocytoma with aggressive clinical behavior in an adult: a case report with genetic characterization2013

    • Author(s)
      Sano K, Toda M, Sasaki H, Kitamura Y, Mikami S, Hirato J, Inoue S, Kawase T, Yoshida K
    • Journal Title

      Brain Tumor Pathol

      Volume: -

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macrophage migration inhibitory factor (MIF) promotes cell survival and proliferation of neural stem/progenitor cells2012

    • Author(s)
      Ohta S, Misawa A, Fukaya R, Inoue S,Kanemura Y, Okano H, Kawakami Y, Toda M
    • Journal Title

      J Cell Sci

      Volume: 125 Pages: 3210-3220

    • DOI

      10.1242/jcs.102210

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of KIF23 suppresses glioma proliferation2012

    • Author(s)
      Takahashi S, Fusaki N, Ohta S, Iwahori Y, Iizuka Y, Inagawa K, Kawakami Y, Yoshida K, Toda M
    • Journal Title

      J Neurooncol

      Volume: 106(3) Issue: 3 Pages: 519-529

    • DOI

      10.1007/s11060-011-0706-2

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgical results of an endoscopic endonasal approach for clival chordomas2012

    • Author(s)
      Saito K, Toda M, Tomita T, Ogawa K, Yoshida K
    • Journal Title

      Acta Neurochir (Wien)

      Volume: 154 (5) Issue: 5 Pages: 879-886

    • DOI

      10.1007/s00701-012-1317-1

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of endoscopic transsphenoidal approach to true type transsellar transsphenoidal meningoencephalocele in an adult: A case report and literature review2012

    • Author(s)
      Saito K, Toda M, Tomita T, Sano K, Ogawa K, Yoshida K
    • Journal Title

      Acta Neurochir (Wien)

      Volume: 154 Issue: 8 Pages: 1511-1515

    • DOI

      10.1007/s00701-012-1346-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidural anterior petrosectomy with subdural visualization of sphenobasal vein via the anterior transpetrosal approach-technical case report.2012

    • Author(s)
      Ichimura S, Yoshida K, Kagami H, Inaba M, Orii M, Kitamura Y, Saga I, Toda M
    • Journal Title

      Neurosurg Rev

      Volume: 35 Issue: 4 Pages: 609-613

    • DOI

      10.1007/s10143-012-0405-2

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain Tumor Stem Cells and Immunotherapy2012

    • Author(s)
      Saga I, Toda M
    • Journal Title

      Journal of Cancer Research Updates

      Volume: 1 Issue: 1 Pages: 28-38

    • DOI

      10.6000/1929-2279.2012.01.01.06

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macrophage migration inhibitory factor (MIF) promotes cell survival and proliferation of neural stem/progenitor cells2012

    • Author(s)
      Ohta S, Misawa A, Fukaya R, Inoue S, Kanemura Y Okano H, Kawakami Y, Toda M
    • Journal Title

      J Cell Sc

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgical results of an endoscopic endonasal approach for clival chordomas2012

    • Author(s)
      Saito K, Toda M, Tomita T, Ogawa K, Yoshida K
    • Journal Title

      Acta Neurochir

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells2011

    • Author(s)
      Tabuse M, Ohta S, Ohashi Y, Fukaya R, Misawa A, Yoshida K, Kawase T, Saya H, Thirant C, Chneiweiss H, Matsuzaki Y, Okano H, Kawakami Y, Toda M
    • Journal Title

      Mol Cancer

      Volume: 10 Issue: 1 Pages: 60-60

    • DOI

      10.1186/1476-4598-10-60

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells.2011

    • Author(s)
      Takahashi S, Yamada-Okabe H, Hamada K, Ohta S, Kawase T, Yoshida K, Toda M
    • Journal Title

      J Neurooncol

      Volume: 103(2) Issue: 2 Pages: 267-276

    • DOI

      10.1007/s11060-010-0398-z

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adjuvant effects of formalin-inactivated HSV through activation of dendritic cells and inactivation of myeloid-derived suppressor cells in cancer immunotherapy.2011

    • Author(s)
      Tsukada-O K, Ohta S, Kawakami Y, Toda M
    • Journal Title

      Int J Cancer

      Volume: 123(1) Issue: 1 Pages: 119-131

    • DOI

      10.1002/ijc.25319

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells2011

    • Author(s)
      Takahashi S, Yamada-Okabe H, Hamada K, Ohta S, Kawase T, Yoshida K, Toda M
    • Journal Title

      J Neurooncol

      Volume: 103(2) Pages: 267-276

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeted inhibition of the p38 MAP kinase of IL-10-secreting CD25-T regulatory cells in cancer immunotherapy2011

    • Author(s)
      Tsukada-O K, Toda M, Udono H, Kawakami Y, Takahashi K
    • Journal Title

      Eur J Immunol

      Volume: 40(4) Pages: 1011-1021

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒト神経膠芽腫由来の癌幹細胞に対する腫瘍崩壊性単純ヘルペスウイルスベクター(oHSV)を用いた治療2011

    • Author(s)
      戸田正博
    • Journal Title

      Brain & Nerve

      Volume: 18(1) Pages: 12-13

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Targeted inhibition of the p38 MAP kinase of IL-10-secreting CD25- T regulatory cells in cancer immunotherapy2010

    • Author(s)
      Tsukada-O K, Toda M, Udono H, Kawakami Y, Takahashi K
    • Journal Title

      Eur J Immunol

      Volume: 40(4) Issue: 4 Pages: 1011-1021

    • DOI

      10.1002/eji.200939513

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of cancer stem-like cells from a side population of a human glioblastoma cell line2010

    • Author(s)
      Fukaya R, Ohta S, Yamaguchi M, Fujii H, Kawakami Y, Kawase T, Toda M
    • Journal Title

      SK-MG-1Cancer Let

      Volume: 291(2) Pages: 150-157

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation of cancer stem-like cells from a side population of a human glioblastoma cell line, SK-MG-12010

    • Author(s)
      Fukaya R, Ohta S, Yamaguchi M, Fujii H, Kawakami Y, Kawase T, Toda M
    • Journal Title

      Cancer Let

      Volume: 291(2) Pages: 150-157

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunotherapy targeted at brain cancer stem cells2010

    • Author(s)
      Toda M
    • Journal Title

      The Open Cancer Immunology Journal

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Downregulation of uPARAP mediates cytoskeletal rearrangements and decreases invasion and migration properties in glioma cells2010

    • Author(s)
      Takahashi S, Yamada-Okabe H, Hamada K, Ohta S, Kawase T, Yoshida K, Toda M
    • Journal Title

      J Neurooncol

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain tumor stem cells and anti-angiogenetic therapy2010

    • Author(s)
      Saito K, Yoshida K, Toda M
    • Journal Title

      Cancer Stem Cells

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 内視鏡頭蓋底手術2010

    • Author(s)
      戸田正博
    • Journal Title

      No Shinkei Geka

      Volume: 38(6) Pages: 505-514

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳腫瘍幹細胞抗原の同定とグリオーマ治療への応用2010

    • Author(s)
      戸田正博
    • Journal Title

      癌と化学療法

      Volume: 37(6) Pages: 1016-1018

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 脳腫瘍に対する治療の現状 免疫療法の役割と今後の展望2010

    • Author(s)
      若林俊彦、岩立康男、森内秀祐、戸田正博
    • Journal Title

      FOURTH

      Volume: 12 Pages: 3-7

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Subtemporal approach-注意すべき静脈灌流路と局所解剖を中心に-2010

    • Author(s)
      戸田正壇、吉田一成、河瀬斌
    • Journal Title

      脳神経外科ジャーナル別刷

      Volume: 19(10) Pages: 742-752

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳腫瘍幹細胞マーカーを標的とした免疫療法の開発2010

    • Author(s)
      戸田正博
    • Journal Title

      Biotherapy

      Volume: 24(6) Pages: 465-473

    • Related Report
      2010 Annual Research Report
  • [Presentation] 再発悪性グリオーマに対するペプチドワクチン2013

    • Author(s)
      戸田正博
    • Organizer
      第9回信濃町脳腫瘍セミナー
    • Place of Presentation
      慶應義塾大学医学部新教育研究棟 (東京)
    • Year and Date
      2013-02-16
    • Related Report
      2012 Final Research Report
  • [Presentation] リボソーム合成阻害を介した治療標的分子としてのグリオーマ新規抗原EFTUD1の解析2012

    • Author(s)
      斉藤克也、戸田正博、吉田一成
    • Organizer
      第30回日本脳腫瘍学会学術集会
    • Place of Presentation
      グランドホテル広島(広島)
    • Year and Date
      2012-11-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 進行・再発悪性グリオーマに対するVEGFRワクチンの第1/2相臨床試験2012

    • Author(s)
      戸田正博、斉藤克也、植田 良、佐々木光、吉田一成
    • Organizer
      第30回日本脳腫瘍学会学術集会
    • Place of Presentation
      グランドホテル広島(広島)
    • Year and Date
      2012-11-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 遺伝学的解析に基づいた神経膠腫の治療戦略2012

    • Author(s)
      戸田正博
    • Organizer
      第24回脳神経外科臨床講座
    • Place of Presentation
      ベルサール八重洲(東京)
    • Year and Date
      2012-11-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経膠芽腫に対するVEGFRワクチンの臨床試験2012

    • Author(s)
      戸田正博
    • Organizer
      第8回信濃町脳腫瘍セミナー
    • Place of Presentation
      慶應義塾大学医学部新教育研究棟 (東京)
    • Year and Date
      2012-02-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経膠芽腫に対するVEGFRワクチンの臨床試験2012

    • Author(s)
      戸田正博
    • Organizer
      第8回信濃町脳腫瘍セミナー
    • Place of Presentation
      慶應義塾大学病院(東京)(招待講演)
    • Year and Date
      2012-02-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 神経膠腫に対する免疫療法について2012

    • Author(s)
      戸田正博
    • Organizer
      グリオーマ(神経膠腫)の患者・家族のためのセミナー
    • Place of Presentation
      慶應義塾大学 (東京)
    • Year and Date
      2012-01-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経膠腫に対する免疫療法について2012

    • Author(s)
      戸田正博
    • Organizer
      グリオーマ(神経膠腫)の患者・家族のためのセミナー
    • Place of Presentation
      慶應義塾大学(東京)(招待講演)
    • Year and Date
      2012-01-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 再発膠芽腫に対するVEGFR1/2ペプチドワクチンの臨床試験2012

    • Author(s)
      斉藤克也、植田良、佐々木光、戸田正博、吉田一成
    • Organizer
      第23回東京脳腫瘍治療懇話会
    • Place of Presentation
      センチュリーアイアット東京(東京)
    • Year and Date
      2012-01-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規グリオーマ抗原遺伝子EFTUD1 の同定とその解析2011

    • Author(s)
      斉藤克也、戸田正博、吉田一成
    • Organizer
      第29回日本脳腫瘍学会学術集会
    • Place of Presentation
      下呂温泉 水明館(岐阜)
    • Year and Date
      2011-11-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Gliomaの遺伝子診断とneoadjuvant approach2011

    • Author(s)
      佐々木光、廣瀬雄一、片山真、矢崎貴仁、戸田正博、大平貴之、吉田一成
    • Organizer
      第29回日本脳腫瘍学会学術集会
    • Place of Presentation
      下呂温泉水明館(岐阜県)
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規グリオーマ抗原遺伝子EFTUD1の同定とその解析2011

    • Author(s)
      斉藤克也、戸田正博、吉田一成
    • Organizer
      第29回日本脳腫瘍学会学術集会
    • Place of Presentation
      下呂温泉水明館(岐阜県)
    • Year and Date
      2011-11-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒトグリオーマ及びグリオーマ癌幹細胞におけるHOXD9の機能解析2011

    • Author(s)
      田伏将尚、大多茂樹、大橋陽平、深谷雷太、三沢 彩、吉田一成、河瀬 斌、佐谷秀行、Thirant C、Chneiweiss H、松崎有未、岡野栄之、河上 裕、戸田正博
    • Organizer
      第12回日本分子脳神経外科学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトグリオーマ及びグリオーマ癌幹細胞におけるHOXD9の機能解析2011

    • Author(s)
      田伏将尚、大多茂樹、大橋陽平、深谷雷太、三沢彩、吉田一成、河瀬斌、佐谷秀行、Thirant C、Chneiweiss H、松崎有未、岡野栄之、河上裕、戸田正博
    • Organizer
      第12回日本分子脳神経外科学会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Low-grade gliomaの遺伝子診断とneoadjuvant approach2011

    • Author(s)
      佐々木光、廣瀬雄一、矢崎貴仁、戸田正博、大平貴之、吉田一成
    • Organizer
      日本脳神経外科学会第70回学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-10-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional analysis of HOXD9 in human gliomas and glioma cancer-initiating cells2011

    • Author(s)
      大多茂樹、田伏将尚、大橋陽平、深谷雷太、三沢 彩、吉田一成、河瀬 斌、佐谷秀行、Thirant C、Chneiweiss H、松崎有未、岡野栄之、河上 裕、戸田正博
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      山代温泉(石川)
    • Year and Date
      2011-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional analysis of HOXD9 in human gliomas and glioma cancer-initiating cells2011

    • Author(s)
      大多茂樹、田伏将尚、大橋陽平、深谷雷太、三沢彩、吉田一成、河瀬斌、佐谷秀行、Thirant C、Chneiweiss H、松崎有未、岡野栄之、河上裕、戸田正博
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      瑠璃光(山代温泉)(石川県)
    • Year and Date
      2011-09-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Grade2-3グリオーマに対する遺伝子診断に基づくneoadjuvant approach2011

    • Author(s)
      佐々木光、廣瀬雄一、片山真、矢崎貴仁、戸田正博、大平貴之、吉田一成
    • Organizer
      第16回日本脳腫瘍の外科学会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 癌幹細胞を標的としたSox6ペプチドワクチンの開発2011

    • Author(s)
      戸田正博
    • Organizer
      第2回創薬 Innovation Forum 2011
    • Place of Presentation
      秋葉原UDX Theater(東京)
    • Year and Date
      2011-07-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 神経膠腫(グリオーマ)-特にgrade IIについて-2011

    • Author(s)
      佐々木光、戸田正博
    • Organizer
      脳腫瘍ネットワーク(JBTA)患者家族のためのセミナー
    • Place of Presentation
      慶應義塾大学(東京)(招待講演)
    • Year and Date
      2011-07-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 癌幹細胞を標的としたSox6ペプチドワクチンの開発2011

    • Author(s)
      戸田正博
    • Organizer
      第2回創薬Innovation Forum 2011
    • Place of Presentation
      秋葉原UDX Theater(東京)(招待講演)
    • Year and Date
      2011-07-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional analysis of macrophage migration inhibitory factor (MIF) in the mouse neural stem/progenitor cells2011

    • Author(s)
      Ohta S, Misawa A, Okano H, Kawakami Y, Toda M
    • Organizer
      ISSCR 8th
    • Place of Presentation
      Metro Toronto Convention Centre (Canada)
    • Year and Date
      2011-06-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳腫瘍幹細胞に対する免疫療法の開発と臨床応用へ向けて2011

    • Author(s)
      戸田正博
    • Organizer
      第42回慶應ニューロサイエンス研究会
    • Place of Presentation
      慶應義塾大学病院(東京)(招待講演)
    • Year and Date
      2011-06-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 再発悪性グリオーマに対するVEGFRペプチドワクチンの臨床試験2011

    • Author(s)
      戸田正博
    • Organizer
      第20回J・K・Wフォーラム
    • Place of Presentation
      順天堂大学会議室(東京)
    • Year and Date
      2011-05-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 再発悪性グリオーマに対するVEGFRペプチドワクチンの臨床試験2011

    • Author(s)
      戸田正博
    • Organizer
      第20回J・K・Wフォーラム
    • Place of Presentation
      順天堂大学(東京)
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 再発悪性グリオーマに対する癌ワクチンの臨床試験2011

    • Author(s)
      戸田正博
    • Organizer
      第7回信濃町脳腫瘍セミナー
    • Place of Presentation
      慶應義塾大学 (東京)
    • Year and Date
      2011-02-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳腫瘍幹細胞・グリオーマ共通抗原の発現および機能解析2010

    • Author(s)
      戸田正博、田伏将尚、大多茂樹、深谷雷太、高橋里史、吉田一成
    • Organizer
      第28回日本脳腫瘍学会学術集会
    • Place of Presentation
      軽井沢
    • Year and Date
      2010-11-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳腫瘍幹細胞・グリオーマ共通抗原の発現および機能解析2010

    • Author(s)
      戸田正博、田伏将尚、大多茂樹、深谷雷太、高橋里史、吉田一成
    • Organizer
      第28回日本脳腫瘍学会学術集会
    • Place of Presentation
      軽井沢プリンスホテル(長野)
    • Year and Date
      2010-11-02
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトグリオーマ抗原SOX6とそのT細胞エピトープペプチドの同定2010

    • Author(s)
      植田 良、戸田正博、副田明男、河瀬 斌、河上 裕、吉田一成
    • Organizer
      第69回日本脳神経外科学会
    • Place of Presentation
      福岡コンベンションセンター(福岡)
    • Year and Date
      2010-10-29
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒトグリオーマ抗原SOX6とそのT細胞エピトープペプチドの同定2010

    • Author(s)
      植田良、戸田正博、副田明男、河瀬斌、河上裕、吉田一成
    • Organizer
      日本脳神経外科学会第69回学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] GliomaにおけるKIF23発現の検討と機能解析2010

    • Author(s)
      高橋里史、戸田正博、吉田一成
    • Organizer
      第69回日本脳神経外科学会
    • Place of Presentation
      福岡コンベンションセンター(福岡)
    • Year and Date
      2010-10-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Brain tumor initiating cellとMIFの役割2010

    • Author(s)
      深谷雷太、大多茂樹、 松崎有未、河上裕、岡野栄之、河瀬 斌、吉田一成、戸田正博
    • Organizer
      第69回日本脳神経外科学会
    • Place of Presentation
      福岡コンベンションセンター(福岡)
    • Year and Date
      2010-10-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Brain tumor initiating cellとMIFの役割2010

    • Author(s)
      深谷雷太、大多茂樹、松崎有未、河上裕、岡野栄之、河瀬斌、吉田一成、戸田正博
    • Organizer
      日本脳神経外科学会第69回学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] GliomaにおけるKIF23発現の検討と機能解析2010

    • Author(s)
      高橋里史、戸田正博、吉田一成
    • Organizer
      日本脳神経外科学会第69回学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Low-grade gliomaの遺伝子診断とneoadjuvant approach2010

    • Author(s)
      佐々木光、廣瀬雄一、戸田正博、大平貴之、吉田一成
    • Organizer
      第15回日本脳腫瘍の外科学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Brain tumor initiating cellとp53結合分子MIFの役割2010

    • Author(s)
      深谷雷太、大多茂樹、松崎有未、河上 裕、岡野栄之、河瀬 斌、吉田一成、戸田正博
    • Organizer
      第11回日本分子脳神経外科学会
    • Place of Presentation
      東北大学医学部 艮陵会館 (宮城)
    • Year and Date
      2010-08-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Brain tumor initiating cellとp53結合分子MIFの役割2010

    • Author(s)
      深谷雷太、大多茂樹、松崎有未、河上裕、岡野栄之、河瀬斌、吉田一成、戸田正博
    • Organizer
      第11回日本分子脳神経外科学会
    • Place of Presentation
      仙台
    • Year and Date
      2010-08-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脳神経外科における新しい治療2010

    • Author(s)
      戸田正博
    • Organizer
      カラムスの会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] RNA interference-mediated down-regulation of uPARAP decreases invasion and migration property in glioma cells through reorganization of the actin cytoskeleton.2010

    • Author(s)
      Takahashi S, Toda M, Yamada-Okabe H, Hamada K, Kawase T, Yoshida K
    • Organizer
      慶應ニューロサイエンス
    • Place of Presentation
      東京
    • Year and Date
      2010-05-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Moleclar-guided neoadjuvant approach for gliomas regardless of histology

    • Author(s)
      Sasaki H, Hirose Y, Katayama M, Yazaki T, Toda M, Ohira T, Yoshida K
    • Organizer
      第4回国際脳腫瘍病理シンポジウム
    • Place of Presentation
      名古屋国際会議場 (名古屋)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular-guided neoadjuvant aproach for gliomas

    • Author(s)
      Sasaki H, Hirose Y, Katayama M, Yazaki T, Toda M, Ohira T, Yoshida K
    • Organizer
      The 19th International Brain Tumor Research and Therapy Conference
    • Place of Presentation
      Niagara Falls (Canada)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Low-grade gliomaに対する遺伝子診断に基づくneoadjuvant approach

    • Author(s)
      佐々木光、廣瀬雄一、片山 真、 矢崎貴仁、北村洋平、戸田正博、大平貴之、吉田一成
    • Organizer
      日本脳神経外科学会第71回学術総会
    • Place of Presentation
      大阪国際会議場 (大阪)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 遺伝学的解析に基づいた神経膠腫の治療戦略 指定発言

    • Author(s)
      戸田正博
    • Organizer
      第24回脳神経外科臨床講座
    • Place of Presentation
      ベルサール八重洲 (東京)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 進行・再発悪性グリオーマに対するVEGFRワクチンの第1/2相臨床試験

    • Author(s)
      戸田正博
    • Organizer
      第30回日本脳腫瘍学会学術集会
    • Place of Presentation
      グランドプリンスホテル広島 (広島)
    • Related Report
      2012 Annual Research Report
  • [Presentation] リボソーム合成阻害を介した治療標的分子としてのグリオーマ新規抗原EFTUD1の解析

    • Author(s)
      斉藤克也
    • Organizer
      第30回日本脳腫瘍学会学術集会
    • Place of Presentation
      グランドプリンスホテル広島 (広島)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 再発悪性グリオーマに対するペプチドワクチン

    • Author(s)
      戸田正博
    • Organizer
      第9回信濃町脳腫瘍セミナー
    • Place of Presentation
      慶應義塾大学医学部 新教育研究棟 (東京)
    • Related Report
      2012 Annual Research Report
  • [Book] Glioma AntigenGlioma:Immunotherapeutic approaches, R Yamanaka (Ed.), In Landes Bioscience749, 77-832012

    • Author(s)
      Toda M
    • Total Pages
      232
    • Related Report
      2012 Final Research Report
  • [Book] Glioma: Immunotherapeutic approaches2012

    • Author(s)
      Toda M
    • Total Pages
      232
    • Publisher
      In Landes Bioscience
    • Related Report
      2012 Annual Research Report
  • [Book] Brain tumor stem cells and anti-angiogenetic therapyCancer Stem Cells The Cutting Edge Stanley Shostak (Ed.)2011

    • Author(s)
      Saito K, Yoshida K, Toda M
    • Total Pages
      606
    • Publisher
      InTech
    • Related Report
      2012 Final Research Report
  • [Book] Cancer Stem Cells The Cutting Edge2011

    • Author(s)
      Saito K, Yoshida K, Toda M
    • Publisher
      InTech
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 癌ワクチン2011

    • Inventor(s)
      戸田正博、植田 良
    • Industrial Property Rights Holder
      学校法人慶應義塾
    • Acquisition Date
      2011-10-14
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 癌ワクチン2011

    • Inventor(s)
      戸田正博、植田 良、塚田晃三
    • Industrial Property Rights Holder
      学校法人慶應義塾
    • Acquisition Date
      2011-10-14
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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