Study of the head and neck organ regeneration technology using iPS cells

• Project/Area Number: 22390317
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Fukushima Medical University
• Principal Investigator: OMORI Koichi 福島県立医科大学, 医学部, 教授 (10233272)
• Co-Investigator(Renkei-kenkyūsha): NAKAMURA Tatuo 京都大学, 再生医科学研究所, 准教授 (70227908) ; WADA Ikuo 福島県立医科大学, 医学部, 教授 (40182969)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 頭頸部外科学 / 再生医学 / iPS 細胞 / 再生 / iPS細胞 / 頭頸部 / 分化誘導 / 再生医療

Research Abstract

The purpose of this study is to establish a technique for differentiation from iPS cells into head and neck tissues in order to regenerate head and neck organs. The scaffold involving chondrogenic cells which were differentiated from iPS cells was implanted into the tracheal defect of animal models. Regeneration of the cartilage tissue was histologically recognized. Regeneration of the epithelial-like tissue was also recognized through embryoid bodiesfrom iPS cells. This is the first study to demonstrate the potential of iPS cells for the regeneration of the head and neck tissues.

Research Products

• [Journal Article] Evaluation of the Use of Induced Pluripotent Stem Cells(iPSCs) for the Regeneration of Tracheal Cartilage: (2013)
  • Author(s): Mitsuyoshi Imaizumi,Koichi Omori, et al
  • Journal Title: CellTransplant Volume: 22 Pages: 341-353
• [Journal Article] Implantation site-dependent differences for tracheal regeneration with induced pluripotent stem cells (iPScells) (2013)
  • Author(s): Mitsuyoshi Imaizumi, Koichi Omori, et al
  • Journal Title: ActaOto-Laryngol Volume: 133 Pages: 405-411
• [Journal Article] Potential for Respiratory Epithelium Regeneration From Induced Pluripotent Stem Cells (2013)
  • Author(s): Koshi Otsuki, Koichi Omori, et al
  • Journal Title: Ann Otol Rhinol Laryngol Volume: 122 Pages: 25-32
• [Journal Article] Implantation site-dependent differences for tracheal regeneration with induced pluripotent stem cells (iPS cells) (2013)
  • Author(s): Imaizumi M, Omori K, et al.
  • Journal Title: Acta Oto-Laryngologica Volume: 133 Issue: 4 Pages: 405-411
  • DOI: 10.3109/00016489.2012.742566
  • Peer Reviewed
• [Journal Article] Potential for Respiratory Epithelium Regeneration From Induced Pluripotent Stem Cells (2013)
  • Author(s): Otsuki K, Omori K, et al.
  • Journal Title: Annals of Otology, Rhinology & Laryngology Volume: 122 Pages: 25-32
  • Peer Reviewed
• [Journal Article] Evaluation of the Use of Induced Pluripotent Stem Cells (iPSCs) for the Regeneration of Tracheal Cartilage (2013)
  • Author(s): Imaizumi M, Omori K, et al.
  • Journal Title: Cell Transplantation Volume: 22 Issue: 2 Pages: 341-353
  • DOI: 10.3727/096368912x653147
  • Peer Reviewed
• [Journal Article] Implantation site dependent differences for tracheal regeneration with iPS cells (2011)
  • Author(s): Mitsuyoshi Imaizumi, Koichi Omori, et.al
  • Journal Title: Laryngoscope Volume: 121,S5
  • Peer Reviewed
• [Journal Article] Bioengineered prosthesis with allogenic heterotopic fibroblasts for cricoid regeneration (2011)
  • Author(s): Yukio Nomoto Y, Koichi Omori, et.al
  • Journal Title: Laryngoscope Volume: (Epub)
  • Peer Reviewed
• [Journal Article] Potential of induced pluripotent stem cells for the regeneration of the tracheal wall (2010)
  • Author(s): Mitsuyoshi Imaizumi, Koichi Omori, et al
  • Journal Title: Ann Otol Rhinol Laryngol Volume: 119 Pages: 697-703
• [Presentation] Regeneration of respiratory epithelium-like tissue from induced pluripotent stem cells (2012)
  • Author(s): Koshi Otsuki, Koichi Omori,et al.
  • Organizer: The 92nd Annual Meeting of the American Broncho-Esophagological Association
  • Place of Presentation: San Diego
• [Presentation] 気管の再生医療 (2012)
  • Author(s): 大森孝一
  • Organizer: 日本臨床麻酔学会第32回大会
  • Place of Presentation: 郡山
• [Presentation] Potential of induced pluripotent stem cells for regeneration of the tracheal wall (2012)
  • Author(s): Omori K, Imaizumi M, et al.
  • Organizer: COLLEGIUM OTO-RHINO-LARYNGOLOGICUM AMICITIAE SACRUM
  • Place of Presentation: Rome (Italy)
• [Presentation] Regeneration of respiratory epithelium-like tissue from induced pluripotent stem cells (2012)
  • Author(s): Otsuki K, Omori K, et al.
  • Organizer: 92nd Annual Meeting of The American Broncho-Esophagological Association
  • Place of Presentation: San Diego (U.S.A.)
• [Presentation] マウス iPS 細胞を利用した気管軟骨組織再生:レーザーマイクロダイセクションによる移植細胞のDNA 解析 (2011)
  • Author(s): 今泉光雅、大森孝一、他
  • Organizer: 第112回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 京都
  • Year and Date: 2011-05-20
• [Presentation] マウスiPS細胞を利用した気管軟骨組織再生:レーザーマイクロダイセクションによる移植細胞のDNA解析 (2011)
  • Author(s): 今泉光雅, 大森孝一, 他
  • Organizer: 第112回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 京都
  • Year and Date: 2011-05-20
• [Presentation] Implantation site dependent differences for tracheal regeneration with iPS cells (2011)
  • Author(s): Mitsuyoshi Imaizumi,Koichi Omori, et al
  • Organizer: The 114th Annual Meeting of Triological society
  • Place of Presentation: Chicago
  • Year and Date: 2011-04-29
• [Presentation] Implantation site dependent differences for tracheal regeneration with iPS cells (2011)
  • Author(s): Mitsuyoshi Imaizumi, Koichi Omori, et.al
  • Organizer: The 114th Annual Meeting of Triological society 2011
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2011-04-29
• [Presentation] iPS 細胞移植による気管欠損部の組織再生:フローサイトメーター(FACS)による細胞解析と奇形腫形成 (2011)
  • Author(s): 今泉光雅、大森孝一、他
  • Organizer: 第23回日本喉頭科学会総会・学術講演会
  • Place of Presentation: 旭川
  • Year and Date: 2011-04-10
• [Presentation] iPS細胞移植による気管欠損部の組織再生:フローサイトメーター(FACS)によ細胞解析と奇形腫形成 (2011)
  • Author(s): 今泉光雅, 大森孝一, 他
  • Organizer: 第23回日本喉頭科学会総会・学術講演会
  • Place of Presentation: 旭川
  • Year and Date: 2011-04-10
• [Presentation] Potential of induced pluripotent stem cells for regeneration of the tracheal wall (2011)
  • Author(s): Koichi Omori, Mitsuyoshi Imaizumi,et al
  • Organizer: COLLEGIUM OTO-RHINO-LARYNGOLOGICUM AMICITIAE SACRUM
  • Place of Presentation: Rome
• [Presentation] iPS 細胞を利用した軟骨組織再生:気管組織再生の試み (2010)
  • Author(s): 今泉光雅、大森孝一、他
  • Organizer: 第62回日本気管食道科学会
  • Place of Presentation: 別府
  • Year and Date: 2010-11-05
• [Presentation] iPS細胞を利用した軟骨組織再生:気管組織再生の試み (2010)
  • Author(s): 今泉光雅、大森孝一, 他
  • Organizer: 第62回日本気管食道科学会
  • Place of Presentation: 別府
  • Year and Date: 2010-11-05
• [Presentation] Regenerative Medicine of the Cricoid and Trachea (2010)
  • Author(s): Koichi Omori
  • Organizer: The 4th World Voice Congress
  • Place of Presentation: Seoul
  • Year and Date: 2010-09-09
• [Presentation] Regenerative Medicine of the Cricoid and Trachea (2010)
  • Author(s): Koichi Omori
  • Organizer: The 4^<th> World Voice Congress
  • Place of Presentation: Seoul
  • Year and Date: 2010-09-09