Molecular mechanism of dry eye disease
| Project/Area Number |
22390326
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
TSUBOTA Kazuo 慶應義塾大学, 医学部, 教授 (40163878)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | ドライアイ / 涙腺 / 酸化ストレス / 老化 / 加齢 / 角膜 / 機能性食品因子 |
|---|
| Research Abstract |
The purpose of this study was to elucidate molecular mechanisms of pathogenesis in dry eye associated with lacrimal secretory hypofunction caused by increased oxidative stressand aging. We demonstrated that the increased oxidative stress with aging induce
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Age-Related Dysfunction of the Lacrimal Gland and Oxidative Stress : Evidence from the Cu,Zn-Superoxide Dismutase-1 (Sod1) Knockout Mice.2012
Author(s)
Kojima T, Wakamatsu T, Dogru M, Ogawa Y, Igarashi A, Ibrahim O, Inaba T, Shimizu T, Noda S, Obata H, Nakamura S, Wakamatsu A, Shirasawa T, Shimazaki J, Negishi K, Tsubota K
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Journal Title
Am J Pathol.
Volume: 180
Issue: 5
Pages: 1879-1896
DOI
Related Report
Peer Reviewed
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