| Project/Area Number |
22390330
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Yuhei 北海道大学, 大学院・医学研究科, 教授 (70271674)
OYAMA Akihiko 北海道大学, 大学病院, 講師 (70374486)
FUNAYAMA Emi 北海道大学, 大学院・医学研究科, 助教 (10533630)
HAYASHI Toshihiko 北海道大学, 大学病院, 助教 (00432146)
SAITO Akira 北海道大学, 大学院・医学研究科, 非常勤講師 (70507574)
OZAKI Michitaka 北海道大学, 大学院・医学研究科, 特任教授 (80256510)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUTSUMIDA Arata 国立がん研究センター, 中央病院・皮膚腫瘍科, 医長 (00374489)
KUGE Yuji 北海道大学, 大学院・医学研究科, 教授 (70321958)
OASHI Kohei 北海道大学, 大学院・医学研究科, 非常勤講師 (00640343)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 悪性黒色腫 / リンパ浮腫 / in-transit 転移 / マウス / in-transit転移 / 転移 / リンパ節 / イメージング / 癌転移 |
|---|
| Research Abstract |
We reproduced melanoma in-transit metastasis (ITM) in a mouse hind limb by transplanting melanoma cells into the footpad of a mouse with lymphedema (LE). The tumor cells at the ITM site were highly proliferative, and mice with ITMs were more likely than control mice to develop distant lymph node and lung metastases. Peritumoral lymphatic vessels and tumor-associated blood vessels were increased in the primary tumor site of the LE mice.
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