| Project/Area Number |
22390341
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Masaki 日本大学, 歯学部, 准教授 (70361623)
HARADA Hidemitsu 岩手医科大学, 歯学部, 教授 (70271210)
IDA Hiroko 新潟大学, 医歯学系, 准教授 (60293213)
NAKATOMI Mitsushiro 新潟大学, 医歯学系, 助教 (10571771)
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| Co-Investigator(Renkei-kenkyūsha) |
WATANABE Nobukazu 東京大学, 医科学研究所, 特任准教授 (10334278)
MUTOH Noriko 神奈川歯科大学, 歯学部, 講師 (40510433)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
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| Keywords | 歯髄幹細胞 / 前駆細胞 / 象牙芽細胞 / 象牙質形成 / 象牙質・歯髄複合体 / 歯の再植 / 歯の移植 / 幹細胞ニッチ / BrdU / 歯の他家移植 / 骨組織形成 / in vitro |
|---|
| Research Abstract |
Dental pulp stem cells retain proliferative activity and differentiation capacity for odontoblasts during pulpal healing following tooth injuries. Furthermore, donor-host interactions play a crucial role in the reorganization of dental pulp. We succeeded to establish the useful in vitro culture system for the evaluation of the dentin-pulp complex regeneration. These chronological changes in the pulp-dentin border in the in vitro organ culture were similar to the changes in the in vivo experimental models such as tooth replantation/transplantation.
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