Activation of regulatory T cells by oral inhabitant bacteria and relationship of their existence and growth of cancer
Project/Area Number |
22390352
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pathobiological dentistry/Dental radiology
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Research Institution | Hokkaido University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
HASEBE Akira 北海道大学, 大学院・歯学研究科, 助教 (90281815)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
|
Keywords | 炎症 / ガン / 制御性T細胞 / 抗腫瘍活性 / 口腔細菌 / 口腔レンサ球菌 / リポタンパク質 / B16メラノーマ / NK細胞 / TLR2 / Toll-like receptor / リポペプチドFSL-1 / 腫瘍 |
Research Abstract |
Both wild-type (WT) and lipoprotein-deficient (dLP) strains of oral streptococci, S. mutans and S. gordonii, increased the proliferation of CD4+CD25+Foxp3+ regulatory T cells, but reduced their suppressive activity. However, the presence of lipoprotein was not involved in these activities.WT strain of S. gordonii suppressed the growth of B16 melanoma in C57BL/6 mice, whereas dLP strain did not, suggesting that the presence of lipoprotein plays an important role in the anti-tumor activity. In addition, it was found that NK cells, but not cytolytic T cells, were involved in the anti-tumor acitivity.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Toll-like receptor 2-mediated modulation of growth and functions of regulatory T cells by oral streptococci.2013
Author(s)
A. Saeki, T. Segawa, T. Abe, M. Sugiyama, T. Arimoto, H. Hara, A.Hasebe, M. Ohtani, N. Tanizume, M. Ohuchi, H. Kataoka, M. Kawanami, A. Yokoyama and K. Shibata.
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Journal Title
Mol Oral Microbiol
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Mycoplasma Removal from Cell Culture Using Antimicrobial Photodynamic Therapy2013
Author(s)
A Hasebe, I Ishikawa, H M Shamsul, M Ohtani, T Segawa, A Saeki, N Tanizume, M Oouchi, Y Okagami, T Okano, and K Shibata
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Journal Title
Photomed Laser Surg
Volume: 31
Pages: 1-7
NAID
Related Report
Peer Reviewed
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[Journal Article] Toll-like receptor 2-mediated modulation of growth and functions of regulatory T cells by oral streptococci2013
Author(s)
A. Saeki, T. Segawa, T. Abe, M. Sugiyama, T. Arimoto, H. Hara, A.Hasebe, M. Ohtani, N. Tanizume, M. Ohuchi, H. Kataoka, M. Kawanami, A. Yokoyama and K. Shibata.
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Journal Title
Mol Oral Microbiol
Volume: 未定
Issue: 4
Pages: 1-14
DOI
Related Report
Peer Reviewed
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[Journal Article] In vivo anti-and pro-tumour activities of the TLR2 ligandFSL-12011
Author(s)
K Kiura, A Hasebe, A Saeki, T Segawa, F Okada, H M Shamsul, M Ohtani , T Into, N Inoue, M Wakita, K Shibata
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Journal Title
Immunobiology
Volume: 216
Pages: 891-900
Related Report
Peer Reviewed
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[Journal Article] In vivo anti- and pro-tumour activities of the TLR2 ligand FSL-12011
Author(s)
K Kiura, A Hasebe, A Saeki, T Segawa, F Okada, H M Shamsul, M Ohtani, T Into, N Inoue, M Wakita, K Shibata
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Journal Title
Immunobiology
Volume: In press
Related Report
Peer Reviewed
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