| Project/Area Number |
22390366
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
MAEKAWA Kenji 岡山大学, 医歯(薬)学総合研究科, 准教授 (20304313)
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| Co-Investigator(Kenkyū-buntansha) |
HAYAKAWA Satoshi 岡山大学, 大学院・自然科学研究科, 教授 (20263618)
SONOYAMA Wataru 岡山大学, 大学病院, 講師 (40325121)
KUBOKI Takuo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00225195)
峯 篤史 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60379758)
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| Co-Investigator(Renkei-kenkyūsha) |
ITOH Yoshihiro 独立行政法人理化学研究所, 伊藤ナノ医工学研究所, 研究員 (40192497)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | チタン合金 / 表面改質 / アパタイト / 自己析出 / 骨結合促進 / 熱化学処理 / インプラント / チタン / 上皮結合 / 歯根膜 / 幹細胞 / 象牙質 / 酸化膜 / ラット / 骨芽細胞 |
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| Research Abstract |
Our previous technique for apatite deposition onto the titanium surface after insertion in human body, can be only applied to the pure titanium surface. However, in order to apply this surface modification technique to clinically used implants, improvement of the technique is necessary, because all the commercially available titanium implants are made from titanium alloy. For this purpose, we developed liquid phase deposition (LPD) technique, which can induce the apatite formation onto the titanium alloy surface after insertion in human body. We found that rat bone marrow stromal cells (rBMSC) can be attached to this modified titanium alloy surface (treated by LPD technique) and the osseogenesis of rBMSC tended to be accelerated. Recently, the investigation of the bioactivity of this surface modification technique using rat model is still ongoing.
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