| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Research Abstract |
The final goal of this study is to develop a novel treatment for salivary gland dysfunction by cell transplantation. First, we established a mouse salivary gland atrophy model by irradiation. The administration of MNCs significantly increased saliva secretion as similar to the experiments with cultured salivary epithelial cells or mesenchymal stem cells. To understand the mechanism of salivary gland recovery by cell transplantation, in vitro salivary gland atrophy model was established. The results from this study have shown that the transplanted cells may affect the function of salary gland acinar cells via factors secreted from MNCs.
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