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The role of interleukin-6 epigenetics in the pathogenesis of periodontitis and rheumatoid arthritis

Research Project

Project/Area Number 22390396
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionNiigata University

Principal Investigator

YOSHIE Hiromasa  新潟大学, 医歯学系, 教授 (20143787)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Tetsuo  新潟大学, 医歯学総合病院, 准教授 (00215344)
KUBOTA Takehiko  新潟大学, 医歯学総合病院, 講師 (50303136)
KOMATSU Yasutaka  新潟大学, 医歯学総合病院, 助教 (40422597)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords歯周炎 / リウマチ / IL-6 / エピジェネティクス / エピジェネティクス / インターロイキン6 / ゲノム
Research Abstract

The aim of this study was to elucidate the role of interleukin-6 gene methylation in the pathogenesis of periodontitis and rheumatoid arthritis. The results indicated that the gene contained 19 methylation motifs, and hypomethylated status of a single motif was associated with two diseases. Additionally, methylation level was decreased in the gingival than those in blood, suggesting an increased level of IL-6 gene activity and inflammatory condition.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (38 results)

All 2013 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (24 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Assessment of Interleukin-6 Receptor Inhibition Therapy on Periodontal Condition in Patients with Rheumatoid Arthritis and Chronic Periodontitis2013

    • Author(s)
      Kobayashi T, Okada M, Ito S, Kobayashi D, Ishida K, Kojima A, Narita I, Murasawa A, Yoshie H
    • Journal Title

      J. Periodontol

      Volume: (in press) Issue: 1 Pages: 57-67

    • DOI

      10.1902/jop.2013.120696

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-6 gene promoter methylation in rheumatoid arthritis and chronic periodontitis2012

    • Author(s)
      Ishida K, Kobayashi T, Ito S, Komatsu Y, Yokoyama T, Okada M, Abe A, Murasawa A, Yoshie H
    • Journal Title

      J Periodontol

      Volume: 83(7) Issue: 7 Pages: 917-925

    • DOI

      10.1902/jop.2011.110356

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of the FcγRIIB-nt645+25A/G polymorphism with the expression level of the FcγRIIb receptor, the antibody response to Porphyromonas gingivalis and the severity of periodontitis2012

    • Author(s)
      Sugita N, Iwanaga R, Kobayashi T, Yoshie H
    • Journal Title

      J Periodont Res

      Volume: 47(1) Issue: 1 Pages: 105-113

    • DOI

      10.1111/j.1600-0765.2011.01411.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 歯周炎と関節リウマチ-関連性と臨床対応-2012

    • Author(s)
      小林哲夫、吉江弘正
    • Journal Title

      日本歯周病学会会誌

      Volume: 54巻1号 Pages: 11-17

    • NAID

      10030555150

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of human-type monoclonal antibod es against reduced form of hemin binding protein 35 from Porphyromonas gingivalis.2011

    • Author(s)
      Shibata Y, Okano S, Shiroza T, Tahara T, Nakazawa K, Kataoka S, Ishida I, Kobayashi T, Yoshie H, Abiko Y
    • Journal Title

      J Periodontal Res.

      Volume: Vol46 Issue: 6 Pages: 673-81

    • DOI

      10.1111/j.1600-0765.2011.01389.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antibody responses to periodontopathic bacteria in relation to rheumatoid arthritis in Japanese adults2011

    • Author(s)
      Okada M, Kobayashi T, Ito S, Yokoyama T, Komatsu Y, Abe A, Murasawa A, Yoshie H
    • Journal Title

      J.Periodontol

      Volume: 82(10) Issue: 10 Pages: 1433-1441

    • DOI

      10.1902/jop.2011.110020

    • Related Report
      2012 Final Research Report 2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues2011

    • Author(s)
      Abe D, Kubota T, Morozumi T, Shimizu T, Nakasone N, Itagaki M, Yoshie H
    • Journal Title

      J Periodontal Res

      Volume: 46 Issue: 3 Pages: 345-353

    • DOI

      10.1111/j.1600-0765.2011.01349.x

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic profiling of human neutrophils in relation to immunoglobulin G Fc receptor IIIB polymorphism2010

    • Author(s)
      Yokoyama T, Kobayashi T, Yamamoto K, Yamagata A, Oofusa K, Yoshie H
    • Journal Title

      J Periodont Res

      Volume: 45(6) Issue: 6 Pages: 780-787

    • DOI

      10.1111/j.1600-0765.2010.01300.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults2010

    • Author(s)
      Kobayashi T, Murasawa A, Komatsu Y, Yokoyama T, Yamamoto K, Ishida K, Abe A, Yamamoto K, Yoshie H
    • Journal Title

      J. Periodontol

      Volume: 81(5) Issue: 5 Pages: 650-657

    • DOI

      10.1902/jop.2010.090688

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum cytokine and periodontal profiles in relation to disease activity of rheumatoid arthritis in Japanese adults2010

    • Author(s)
      Tetsuo Kobayashi
    • Journal Title

      Journal of Periodontology

      Volume: VOL.81 Pages: 650-657

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Effects of Anti-Tumor Necrosis Factor Therapy on Periodontal Condition in Patients with Rheumatoid Arthritis2012

    • Author(s)
      Kobayashi T
    • Organizer
      The 52nd. Annual Scientific Meeting of the Korean Academy of Periodontology
    • Place of Presentation
      Seoul, Korea.
    • Year and Date
      2012-11-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Improvement of the Activity of Rheumatoid Arthritis by Periodontal Therapy2012

    • Author(s)
      Okada M
    • Organizer
      The 52nd. Annual Scientific Meeting of the Korean Academy of Periodontology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2012-11-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 歯周炎罹患歯肉におけるIL-6遺伝子プロモーター領域のメチル化解析2012

    • Author(s)
      石田光平
    • Organizer
      日本歯科保存学会2012年度秋季学術大会(第137回)
    • Place of Presentation
      広島
    • Year and Date
      2012-11-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 関節リウマチおよび歯周炎の関連血清タンパク質のプロテオーム解析2012

    • Author(s)
      横山智子
    • Organizer
      第55回秋季日本歯周病学会学術大会
    • Place of Presentation
      筑波
    • Year and Date
      2012-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 関節リウマチおよび慢性歯周炎患者における血漿アミノ酸解析2012

    • Author(s)
      岡田萌
    • Organizer
      第55回秋季日本歯周病学会学術大会
    • Place of Presentation
      筑波
    • Year and Date
      2012-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Improvement of periodontal condition by anti-tumor necrosis factor therapy in rheumatoid arthritis patients2012

    • Author(s)
      Kobayashi T
    • Organizer
      EuroPerio 7
    • Place of Presentation
      Vienna, Austria.
    • Year and Date
      2012-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of periodontal therapy on the condition of rheumatoid arthritis2012

    • Author(s)
      Okada M
    • Organizer
      EuroPerio 7
    • Place of Presentation
      Vienna, Austria.
    • Year and Date
      2012-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗TNF療法による関節リウマチ患者の歯周組織状態の改善2012

    • Author(s)
      小林哲夫
    • Organizer
      第55回春季日本歯周病学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2012-05-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 歯周治療による関節リウマチへの影響2012

    • Author(s)
      岡田萌
    • Organizer
      第55回春季日本歯周病学会学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2012-05-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗TNF療法による関節リウマチ患者の歯周組織状態への影響2012

    • Author(s)
      小林哲夫
    • Organizer
      第56回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Proteomic profiling of human serum in relation to rheumatoid arthritis and periodontitis2012

    • Author(s)
      Yokoyama T
    • Organizer
      The 98th. Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology
    • Place of Presentation
      Los Angels, USA.
    • Related Report
      2012 Final Research Report
  • [Presentation] 関節リウマチおよび歯周炎患者におけるIL-6遺伝子プロモーター領域のメチル化解析2011

    • Author(s)
      石田光平
    • Organizer
      第54回秋季日本歯周病学会学術大会
    • Place of Presentation
      下関.
    • Year and Date
      2011-09-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 関節リウマチおよび歯周炎患者におけるIL-6遺伝子プロモーター領域のメチル化解析2011

    • Author(s)
      石田光平
    • Organizer
      第54回秋季日本歯周病学会学術大会
    • Place of Presentation
      海峡メッセ(山口県下関市)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] TACE及びTIMP-3の薬物性歯肉増殖症と歯周炎の歯肉組織における遺伝子発現とタンパク質局在2011

    • Author(s)
      冨田尊志
    • Organizer
      第54回秋季日本歯周病学会学術大会
    • Place of Presentation
      海峡メッセ(山口県下関市)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 関節リウマチにおける歯周炎関連タンパク質の網羅的解析2011

    • Author(s)
      小林哲夫
    • Organizer
      日本歯科保存学会2011年度春季学術大会(第134回)
    • Place of Presentation
      浦安
    • Year and Date
      2011-06-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 歯周炎関連血清タンパク質のプロテオーム解析2011

    • Author(s)
      横山智子
    • Organizer
      日本歯科保存学会2011年度春季学術大会(第134回)
    • Place of Presentation
      浦安
    • Year and Date
      2011-06-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 歯周病原細菌に対する血清抗体価と関節リウマチとの関連2011

    • Author(s)
      岡田萌
    • Organizer
      日本歯科保存学会2011年度春季学術大会(第134回)
    • Place of Presentation
      浦安
    • Year and Date
      2011-06-09
    • Related Report
      2012 Final Research Report
  • [Presentation] I nterleukin-6 gene promoter methylation in relation to rheumatoid arthritis and periodontitis2011

    • Author(s)
      Ishida K
    • Organizer
      The 97th. Annual Meeting of the American Academy of Periodontology
    • Place of Presentation
      Miami, USA.
    • Related Report
      2012 Final Research Report
  • [Presentation] Serum cytokine and periodontal profiles related to rheumatoid arthritis activity2010

    • Author(s)
      Kobayashi T
    • Organizer
      The 96th. Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology
    • Place of Presentation
      Honolulu, USA.
    • Year and Date
      2010-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Genetic influence of serum interleukin-6 and its soluble receptor levels2010

    • Author(s)
      Komatsu Y
    • Organizer
      The 96th. Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology
    • Place of Presentation
      Honolulu, USA.
    • Year and Date
      2010-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] DNA methylation status of the interleukin-6 gene promoter in periodontitis2010

    • Author(s)
      Ishida K
    • Organizer
      The 96th. Annual Meeting of the American Academy of Periodontology in collaboration with the Japanese Society of Periodontology
    • Place of Presentation
      Honolulu, USA.
    • Year and Date
      2010-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 歯周炎および関節リウマチ患者におけるIL-6遺伝子プロモーター領域のメチル化解析2010

    • Author(s)
      石田光平
    • Organizer
      第53回秋季日本歯周病学会学術大会
    • Place of Presentation
      高松
    • Year and Date
      2010-09-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 歯周炎および関節リウマチ患者におけるIL-6遺伝子プロモーター領域のメチル化解析2010

    • Author(s)
      石田光平
    • Organizer
      第53回秋季日本歯周病学会学術大会
    • Place of Presentation
      サンポートホール高松(香川県高松市)
    • Year and Date
      2010-09-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 歯周炎罹患歯肉におけるIL-6遺伝子プロモーター領域のメチル化解析

    • Author(s)
      石田光平
    • Organizer
      日本歯科保存学会2012年度秋季学術大会(第137回)
    • Place of Presentation
      広島国際会議場(広島県広島市)
    • Related Report
      2012 Annual Research Report
  • [Book] イラストで語る歯科医学最前線2013

    • Author(s)
      小林哲夫、吉江弘正
    • Publisher
      クインテッセンス出版
    • Related Report
      2012 Final Research Report
  • [Book] AT THE FOREFRONT. Illustrated Topics in Dental Research and Clinical Practice2012

    • Author(s)
      Tetsuo Kobayashi、Hiromasa Yoshie
    • Publisher
      Quintessence Publishing Co, Inc
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://mds.niigata-u.ac.jp/organization/ols/obs/per/index_j.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://mds.niigata-u.ac.jp/organization/ols/obs/per/indexj.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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