The role of interleukin-6 epigenetics in the pathogenesis of periodontitis and rheumatoid arthritis
Project/Area Number |
22390396
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Periodontal dentistry
|
Research Institution | Niigata University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Tetsuo 新潟大学, 医歯学総合病院, 准教授 (00215344)
KUBOTA Takehiko 新潟大学, 医歯学総合病院, 講師 (50303136)
KOMATSU Yasutaka 新潟大学, 医歯学総合病院, 助教 (40422597)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2010: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
|
Keywords | 歯周炎 / リウマチ / IL-6 / エピジェネティクス / エピジェネティクス / インターロイキン6 / ゲノム |
Research Abstract |
The aim of this study was to elucidate the role of interleukin-6 gene methylation in the pathogenesis of periodontitis and rheumatoid arthritis. The results indicated that the gene contained 19 methylation motifs, and hypomethylated status of a single motif was associated with two diseases. Additionally, methylation level was decreased in the gingival than those in blood, suggesting an increased level of IL-6 gene activity and inflammatory condition.
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Report
(4 results)
Research Products
(38 results)