An attempt to analysis of protein expression data as functional data, and cancer individualization diagnosis

• Project/Area Number: 22500271
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Statistical science
• Research Institution: Tohoku University (2012); Japanese Foundation For Cancer Research (2010-2011)
• Principal Investigator: MIYATA Satoshi 東北大学, 大学院・医学系研究科, 講師 (60360343)
• Co-Investigator(Kenkyū-buntansha): ISOMURA Minoru 島根大学, 医学部, 講師 (40272497)
• Co-Investigator(Renkei-kenkyūsha): MATSUURA Masaaki 公益財団法人がん研究会, がんゲノム研究部, 部長 (40173794)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ゲノム統計解析 / 関数データ解析 / 非線型回帰 / 統計数学 / 非線形回帰

Research Abstract

To extract functional data from protein expression profile, smoothing for functions with locally different smoothness was applied. We developed theoretical investigation of adaptive free-knot splines (AFKS), and implemented programing for it. We also interpreted that protein expression profile is obtained from probability distributions with indifferentiable points, and we analyzed estimation problem of extremely illegal probability distributions. The optimization of knots of spline functions was attained by optimizing the adaptive model selection criterion (AMSC) with evolutionary algorithms.

Research Products

• [Journal Article] Effect of the Great East Japan Earthquake on cardiovascular diseases--report from the 10 hospitals in the disaster area (2013)
  • Author(s): Aoki T, Takahashi J, Fukumoto Y, Yasuda S, Ito K, Miyata S, Shinozaki T, Inoue K, Yagi T, Komaru T, Katahira Y, Obata A, Hiramoto T
  • Journal Title: Circ J Volume: 77(2) Pages: 490-493
  • NAID: 10031138930
  • URL: https://www.jstage.jst.go.jp/article/circj/77/2/77_CJ-12-1594/_article
  • Peer Reviewed
• [Journal Article] The Great East Japan Earthquake Disaster and cardiovascular diseases. (2012)
  • Author(s): Tatsuo Aoki
  • Journal Title: Eur Heart J. Volume: 33 Issue: 22 Pages: 2796-2803
  • DOI: 10.1093/eurheartj/ehs288
  • Peer Reviewed
• [Journal Article] Japanese Society for Cancer of the Colon and Rectum. "Results of a Japanese nationwide multi-institutional study on lateral pelvic lymph node metastasis in low rectal cancer: is it regional or distant disease?" (2012)
  • Author(s): Akiyoshi T, Watanabe T, Miyata S, Kotake K, Muto T, Sugihara K
  • Journal Title: Ann Surg Volume: 255(6) Issue: 6 Pages: 1129-1134
  • DOI: 10.1097/sla.0b013e3182565d9d
  • Peer Reviewed
• [Journal Article] Clinical impact ofintraoperative detection of carcinoembryonic antigen mRNA in pleural lavage specimens from nonsmall cell lung cancer patients (2012)
  • Author(s): Satoh Y, Sugai S, Uehara H, Mun M, Sakao Y, Okumura S, Nakagawa K, Ishikawa Y, Miki Y, Miyata S.
  • Journal Title: Thorac Cardiovasc Surg Volume: 60(8) Issue: 08 Pages: 533-540
  • DOI: 10.1055/s-0031-1298066
  • Peer Reviewed
• [Journal Article] Effect of the Great East Japan Earthquake on cardiovascular diseases--report from the 10 hospitals in the disaster area. (2012)
  • Author(s): Aoki T, Takahashi J, Fukumoto Y, Yasuda S, Ito K, Miyata S, Shinozaki T, Inoue K, Yagi T, Komaru T, Katahira Y, Obata A, Hiramoto T, Sukegawa H, Ogata K, Shimokawa H.
  • Journal Title: Circ J. Volume: 77(2): Pages: 490-493
  • NAID: 10031138930
  • Peer Reviewed
• [Journal Article] Characteristics of University Spin-offs in Chemistry on the Business Relationship with Manufactures (2012)
  • Author(s): Yamamoto, K., Miyata, S., Kameyama, H.
  • Journal Title: Journal of Chemical Engineering of Japan Volume: 45 Pages: 239-244
  • Peer Reviewed
• [Journal Article] Malignant transformation of breast fibroadenoma to malignant phyllodes tumor: long-term outcome of 36 malignant phyllodes tumors. (2011)
  • Author(s): Abe M, Miyata S, Nishimura S, Iijima K, Makita M, Akiyama F, Iwase T.
  • Journal Title: Breast Cancer Volume: 18(4) Issue: 4 Pages: 268-272
  • DOI: 10.1007/s12282-009-0185-x
  • NAID: 10030393513
  • Peer Reviewed
• [Journal Article] Prognostic factors for survival after salvage surgery for locoregional recurrence of colon cancer (2011)
  • Author(s): Akiyoshi T, Fujimoto Y, Konishi T, Kuroyanagi H, Ueno M, Oya M, Miyata S, Yamaguchi T.
  • Journal Title: Am J Surg. Volume: 201(6) Issue: 6 Pages: 726-733
  • DOI: 10.1016/j.amjsurg.2010.03.003
  • Peer Reviewed
• [Journal Article] Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis (2010)
  • Author(s): Yokoyama T, Kanno Y, Yamazaki Y, Takahara T, Miyata S, Nakamura T
  • Journal Title: Blood Volume: 116(15) Issue: 15 Pages: 2768-2775
  • DOI: 10.1182/blood-2009-10-246264
  • Peer Reviewed
• [Journal Article] Therapeutic outcomes of endoscopic submucosal dissection of undifferentiated-type intramucosal gastric cancer without ulceration and preoperatively diagnosed as 20 millimetres or less in diameter. (2010)
  • Author(s): Yamamoto Y, Fujisaki J, Hirasawa T, Ishiyama A, Yoshimoto K, Ueki N, Chino A, Tsuchida T, Hoshino E, Hiki N, Fukunaga T, Sano T, Yamaguchi T, Takahashi H, Miyata S, Yamamoto N, Kato Y, Igarashi M.
  • Journal Title: Dig Endosc Volume: 22(2) Issue: 2 Pages: 112-118
  • DOI: 10.1111/j.1443-1661.2010.00945.x
  • NAID: 10028186679
  • Peer Reviewed
• [Journal Article] Discriminant model for cytologic distinction of large cell neuroendocrine carcinoma from small cell carcinoma of the lung (2010)
  • Author(s): Hoshi R, Furuta N, Horai T, Ishikawa Y, Miyata S, Satoh Y.
  • Journal Title: J Thorac Oncol Volume: 5(4) Issue: 4 Pages: 472-478
  • DOI: 10.1097/jto.0b013e3181ce3cdd
  • Peer Reviewed
• [Journal Article] 適応型モデル選択基準を用いた一般化加法モデルの推定 (2010)
  • Author(s): 宮田敏
  • Journal Title: 日本統計学会誌 Volume: Vol.39,Series JNo.2 Pages: 369-391
  • NAID: 110007618322
  • Peer Reviewed
• [Journal Article] A discriminant model for cytologic distinction of large cell neuroendocrine carcinoma from small cell carcinoma of the lung (2010)
  • Author(s): Hoshi, R., Miyata, S., et al.
  • Journal Title: J.Thorac Oncol. Volume: 5(4) Pages: 472-478
  • Peer Reviewed
• [Journal Article] Therapeutic outcomes of endoscopic submucosal dissection of undifferentiated-type intramucosal gastric cancer without ulceration and preoperatively diagnosed as 20 millimetres or less in diameter (2010)
  • Author(s): Yamamoto Y, Miyata, S., et al.
  • Journal Title: Dig Endosc. Volume: 22(2) Pages: 112-118
  • NAID: 10028186679
  • Peer Reviewed
• [Journal Article] Tribl links the MEKI;ERK pathway in myeloid leukemogenesis (2010)
  • Author(s): Takashi Y., Miyata.S., et al.
  • Journal Title: Blood Volume: 116(15) Pages: 2768-2775
  • Peer Reviewed
• [Journal Article] Prognostic factors for survival after salvage surgery for locoregional recurrence of colon cancer (2010)
  • Author(s): Akiyoshi T., Miyata.S., et al.
  • Journal Title: Am J Surg. Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Clinical Impact of Intraoperative Detection of Carcinoembryonic Antigen (CEA) mRNA in Pleural Lavage Specimens from Non-small Cell Lung Cancer
  • Author(s): Satoh, Y., Sugai, S., Uehara, H., Mun, M., Sakao, Y., Okumura, S., Nakagawa, K., Ishikawa, Y., Miki, Y., Miyata, S.
  • Journal Title: Thoracic and Cardiovascular Surgeon Volume: (In press)
  • Peer Reviewed
• [Presentation] New software for imaging mass spectrometry data (2012)
  • Author(s): Masaaki Matsuura, Masaru Ushijima, Akiko Yuba-Kubo, Masatoshi Wakui, Mitsuyo Ohmura, Kurando Hosaka, Takahiro Hayasaka, Noritaka Masaki, Satoshi Miyata, Ikuko Yao, Mitsutoshi Setou, Kiyoshi Ogawa, Shigeki Kajihara
  • Organizer: American Association for Cancer Research Annual Meeting
  • Place of Presentation: Chicago, IL. U.S.A.
  • Year and Date: 2012-04-03
• [Presentation] New software for imaging mass spectrometry data (2012)
  • Author(s): M Ushijima, A Yuba-Kubo, M Wakui, M Ohmura, K Hosaka, T Hayasaka, N Masaki, S Miyata, I Yao, M Setou, K Ogawa, S Kajihara
  • Organizer: American Association for Cancer Research Annual Meeting 2012
  • Place of Presentation: Chicago, IL.U.S.A.
• [Presentation] イメージング質量分析データに基づいて領域を判別するソフトウェアの開発 (2011)
  • Author(s): 梶原茂樹、保坂蔵人、宮田敏、早坂孝宏、井上菜穂子、正木紀隆、久保亜希子、涌井昌俊、矢尾育子、小河潔、瀬藤光利、松浦正明
  • Organizer: 第59回質量分析総合討論会
  • Place of Presentation: ホテル阪急エキスポパーク大阪
  • Year and Date: 2011-09-15
• [Presentation] イメージング質量分析データに基づいて領域を判別するソフトウェアの開発 (2011)
  • Author(s): 梶原茂樹、保坂蔵人、宮田敏、早坂孝宏、井上菜穂子、正木紀隆、久保亜希子、涌井昌俊、矢尾育子、小河潔、瀬藤光利、松浦正明
  • Organizer: 第59回質量分析総合討論会2011
  • Place of Presentation: ホテル阪急エキスポパーク
  • Year and Date: 2011-09-15
• [Presentation] Results of a nationwide Japanese study on lateral pelvic lymph node metastasis in low rectal cancer: Is it regional or distant disease? (2011)
  • Author(s): T. Akiyoshi, T. Watanabe, S. Miyata, K. Kotake, T. Muto, K. Sugihara (2011)
  • Organizer: ASCO Annual Meeting: General Poster Session
  • Place of Presentation: Chicago, Illinois. U.S.A.
• [Presentation] Prediction of response to cancer chemotherapy by generalized additive model (2010)
  • Author(s): Miyata, S., Matsuura, M.
  • Organizer: 8^<th> Joint conference of AACR and JCA
  • Place of Presentation: Waikoloa, Hawaii, U.S.A.
  • Year and Date: 2010-02-08
• [Presentation] Development of detection method for novel fusion gene using Gene Chip Exon Array (2010)
  • Author(s): Wada, Y., Miyata, S., et al.
  • Organizer: 8^<th> Joint conference of AACR and JCA
  • Place of Presentation: Waikoloa, Hawaii, U.S.A.
  • Year and Date: 2010-02-08
• [Presentation] Gene Expression classification of human breast cancer (2010)
  • Author(s): Koichi Nagasaki, Minoru Isomura, Masaaki Matsuura, Masaru Ushijima, Satoshi Miyata, Hutoshi Akiyama, TetsuoNoda, Yoshio Miki
  • Organizer: 69th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Osaka International Convention Center, Osaka
• [Presentation] Development of detection method for novel fusion gene using GeneChip Exon Array (2010)
  • Author(s): Yusaku Wada, Masaaki Matsuura, Minoru Sugawara, Masaru Ushijima, Satoshi Miyata
  • Organizer: 8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association, Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics
  • Place of Presentation: Hilton Waikoloa Village Waikoloa, Hawaii. U.S.A.
• [Presentation] Prediction of response to cancer chemotherapy by generalized additive model (2010)
  • Author(s): Satoshi Miyata, Masaaki Matsuura
  • Organizer: 8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association, Cancer Genomics, Epigenomics, and theDevelopment of Novel Therapeutic
  • Place of Presentation: Hilton Waikoloa Village Waikoloa, Hawaii. U.S.A.
• [Presentation] Gene Expression classification of human breast cancer (2010)
  • Author(s): Nagasaki, K., Miyata, S., et al.
  • Organizer: 69^<th> Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: 大阪国際会議場
• [Presentation] 原発性肺癌における細胞診での予後の推測に関する検討 (2010)
  • Author(s): 星利良, 宮田敏, et al.
  • Organizer: 第51回日本肺癌学会総会
  • Place of Presentation: 広島国際会議場
• [Presentation] 可変節点スプラインを用いた非線型時系列モデルの解析 (2010)
  • Author(s): 宮田敏
  • Organizer: 統計関連学会連合大会
  • Place of Presentation: 早稲田大学早稲田キャンパス
• [Presentation] Application of generalized additive models to prediction of response to cancer chemotherapy (2010)
  • Author(s): Miyata, S., Matsuura, M.
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
• [Presentation] Development of detection method for novel fusion gene using Gene Chip Exon Arrav (2010)
  • Author(s): Wada, Y., Miyata, S., et al.
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場