An attempt to analysis of protein expression data as functional data, and cancer individualization diagnosis
| Project/Area Number |
22500271
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Statistical science
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| Research Institution | Tohoku University (2012)
Japanese Foundation For Cancer Research (2010-2011) |
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Principal Investigator |
MIYATA Satoshi 東北大学, 大学院・医学系研究科, 講師 (60360343)
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| Co-Investigator(Kenkyū-buntansha) |
ISOMURA Minoru 島根大学, 医学部, 講師 (40272497)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUURA Masaaki 公益財団法人がん研究会, がんゲノム研究部, 部長 (40173794)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ゲノム統計解析 / 関数データ解析 / 非線型回帰 / 統計数学 / 非線形回帰 |
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| Research Abstract |
To extract functional data from protein expression profile, smoothing for functions with locally different smoothness was applied. We developed theoretical investigation of adaptive free-knot splines (AFKS), and implemented programing for it. We also interpreted that protein expression profile is obtained from probability distributions with indifferentiable points, and we analyzed estimation problem of extremely illegal probability distributions. The optimization of knots of spline functions was attained by optimizing the adaptive model selection criterion (AMSC) with evolutionary algorithms.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Effect of the Great East Japan Earthquake on cardiovascular diseases--report from the 10 hospitals in the disaster area2013
Author(s)
Aoki T, Takahashi J, Fukumoto Y, Yasuda S, Ito K, Miyata S, Shinozaki T, Inoue K, Yagi T, Komaru T, Katahira Y, Obata A, Hiramoto T
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Journal Title
Circ J
Volume: 77(2)
Pages: 490-493
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] Effect of the Great East Japan Earthquake on cardiovascular diseases--report from the 10 hospitals in the disaster area.2012
Author(s)
Aoki T, Takahashi J, Fukumoto Y, Yasuda S, Ito K, Miyata S, Shinozaki T, Inoue K, Yagi T, Komaru T, Katahira Y, Obata A, Hiramoto T, Sukegawa H, Ogata K, Shimokawa H.
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Journal Title
Circ J.
Volume: 77(2):
Pages: 490-493
NAID
Related Report
Peer Reviewed
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[Journal Article] Therapeutic outcomes of endoscopic submucosal dissection of undifferentiated-type intramucosal gastric cancer without ulceration and preoperatively diagnosed as 20 millimetres or less in diameter.2010
Author(s)
Yamamoto Y, Fujisaki J, Hirasawa T, Ishiyama A, Yoshimoto K, Ueki N, Chino A, Tsuchida T, Hoshino E, Hiki N, Fukunaga T, Sano T, Yamaguchi T, Takahashi H, Miyata S, Yamamoto N, Kato Y, Igarashi M.
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Journal Title
Dig Endosc
Volume: 22(2)
Pages: 112-118
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Clinical Impact of Intraoperative Detection of Carcinoembryonic Antigen (CEA) mRNA in Pleural Lavage Specimens from Non-small Cell Lung Cancer
Author(s)
Satoh, Y., Sugai, S., Uehara, H., Mun, M., Sakao, Y., Okumura, S., Nakagawa, K., Ishikawa, Y., Miki, Y., Miyata, S.
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Journal Title
Thoracic and Cardiovascular Surgeon
Volume: (In press)
Related Report
Peer Reviewed
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[Presentation] New software for imaging mass spectrometry data2012
Author(s)
Masaaki Matsuura, Masaru Ushijima, Akiko Yuba-Kubo, Masatoshi Wakui, Mitsuyo Ohmura, Kurando Hosaka, Takahiro Hayasaka, Noritaka Masaki, Satoshi Miyata, Ikuko Yao, Mitsutoshi Setou, Kiyoshi Ogawa, Shigeki Kajihara
Organizer
American Association for Cancer Research Annual Meeting
Place of Presentation
Chicago, IL. U.S.A.
Year and Date
2012-04-03
Related Report
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[Presentation] New software for imaging mass spectrometry data2012
Author(s)
M Ushijima, A Yuba-Kubo, M Wakui, M Ohmura, K Hosaka, T Hayasaka, N Masaki, S Miyata, I Yao, M Setou, K Ogawa, S Kajihara
Organizer
American Association for Cancer Research Annual Meeting 2012
Place of Presentation
Chicago, IL.U.S.A.
Related Report
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