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Roles of the nucleus accumbens core on development of matching behavior

Research Project

Project/Area Number 22500294
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionDokkyo Medical University (2012-2013)
Fukushima Medical University (2010-2011)

Principal Investigator

KAI Nobuyuki  獨協医科大学, 医学部, 助教 (50301750)

Project Period (FY) 2010-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsマッチングの法則 / マッチング行動 / オペラントマッチング / 側坐核 / ラット / 交代反応 / 強化後休止 / 自発的回復 / スイッチング / マッチング / 対応法則 / イムノトキシン / ドパミン / 神経行動学 / 選択行動 / 側坐核コア / ドパミンD2受容体 / イムノトキシン細胞標的法
Research Abstract

Given two options with different reinforcement rates, animals match their relative rate of responding to the relative rates of reinforcement (i.e., matching behavior). A previous study has shown that the nucleus accumbens core (AcbC) is involved in the performance of matching behavior in trained animals. However, the role of the AcbC in the acquisition of matching behavior has not been addressed. We conducted a series of experimental sessions to examine the role of the AcbC on the development of matching behavior. Lesions of the AcbC accelerated the development of matching behavior compared to the sham-operated group. The AcbC rats showed smaller probabilities of switching behavior between alternatives than shams. Our results suggest that the AcbC plays a regulatory role in the development of matching behavior through switching probabilities rather than perception of reward magnitude.

Report

(4 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2014 2012 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (5 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Lesions of the nucleus accumbens core modulate development of matching behavior2014

    • Author(s)
      Kai N, Tsusui Y, Kobayashi K
    • Journal Title

      BMC Neuroscience 2014

      Volume: 15 Issue: 1 Pages: 55-55

    • DOI

      10.1186/1471-2202-15-55

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lesions of the nucleus accumbens core modulate development of matching behavior2014

    • Author(s)
      Nobuyuki Kai, Yuji Tsutsui, Kazuto Kobayashi
    • Journal Title

      BMC Neuroscience

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lever pressing responses under a fixed-ratio schedule of mice with 6-hydroxydopamine -induced dopamine depletion in the nucleus accumbens2011

    • Author(s)
      Tsutsui Y, Nishizawa K, Kai N, Kobayashi K
    • Journal Title

      Behavioural Brain Research

      Volume: 217 Issue: 1 Pages: 60-66

    • DOI

      10.1016/j.bbr.2010.10.002

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of dopamine D 1 receptor in the hippocampus after establishment of conditioned place preference by cocaine.2011

    • Author(s)
      Tanaka, T., Kai, N., Kobayashi, K., Takano, Y., Hironaka, N.
    • Journal Title

      Neuropharmacology

      Volume: 61 Issue: 4 Pages: 842-848

    • DOI

      10.1016/j.neuropharm.2011.05.032

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lever pressing responses under a fixed-ratio schedule of mice with 6-hydroxydopamine-induced dopamine depletion in the nucleus accumbens2011

    • Author(s)
      甲斐信行
    • Journal Title

      Behav Brain Res

      Volume: 217(1) Pages: 60-66

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] The development of operant matching is regulated by the Nucleus Accumbens core2011

    • Author(s)
      Kai N, Kobayashi K
    • Organizer
      The Society for Neuroscience annual meeting
    • Place of Presentation
      Washington, DC
    • Related Report
      2013 Final Research Report
  • [Presentation] The development of operant matching is regulated by the Nucleus Accumbens core2011

    • Author(s)
      Kai N, Tsutsui Y, Kobayashi K
    • Organizer
      第34回日本神経科学大会2011
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] The development of operant matching is regulated by the Nucleus Accumbens core.2011

    • Author(s)
      Kai N., Kobayashi K.
    • Organizer
      The Society for Neuroscience annual meeting
    • Place of Presentation
      Washington, DC
    • Related Report
      2011 Annual Research Report
  • [Presentation] The development of operant matching is regulated by the Nucleus Accumbens core.2011

    • Author(s)
      Kai N., Tsutsui Y., Kobayashi K.
    • Organizer
      he 34th Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Related Report
      2011 Annual Research Report
  • [Presentation] The role of dopamine D2 receptor-expressing neurons in the nucleus accumbens core in operant matching2010

    • Author(s)
      甲斐信行
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Book] Functional circuitry analysis in rodents using neurotoxins/ immuno- toxins. In Neuromethods, Controlled Genetic Manipulations chapter 102012

    • Author(s)
      Kobayashi K, Okada K, Kai N
    • Publisher
      Humana Press Inc., New York
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://researchmap.jp/read0080396/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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