| Project/Area Number |
22500336
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Yokohama City University |
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Principal Investigator |
SASAKI Yukio 横浜市立大学, 医学研究科, 特任准教授 (10295511)
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| Co-Investigator(Renkei-kenkyūsha) |
GOSHIMA Yoshio 横浜市立大学, 医学研究科, 教授 (00153750)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 分子・細胞・神経生物学 / 成長円錐 / 翻訳調節 / マイクロ RNA / 横浜市 / 神経生物学 / マイクロRNA |
|---|
| Research Abstract |
We have investigated two mRNA-binding, translational trans-acting factors to regulate local translation in axonal growth cones in neurons. We demonstratedthat Zipcode-Binding Protein 1 (ZBP1), an mRNA-binding protein, regulates translation of β-actin mRNA, and then direction of axonal extension, via phosphorylation induced by Brain-Derived Neurotrophic Factor (BDNF). We also found that microRNAs (miRNAs), non-coding RNAs bind to mRNA, exist in growth cones. We indicate the possibility that axonal miRNAs are involved in axonal extension regulated by BDNF.
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