Rejuvenation of neural stem cells
Project/Area Number |
22500339
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
|
Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 神経幹細胞 / 初期化 / 分化 / 神経細胞 / グリア / lncRNA / 再生 / ES細胞 / 転写制御因子 / Coup-TFI/II |
Research Abstract |
We attempted to identify the factors, which regulate plasticity of early embryonic neural stem cells and can rejuvenate late embryonic and adult neural stem cells to be early ones with high plasticity. In the result, we have identified three longon-cordin
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells.2010
Author(s)
Sato, T., Shimazaki T, Naka, H., Fukami, S., Satoh, Y., Okano, H., Lax, I., Schlessinger, J., & Gotoh, N.
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Journal Title
Stem Cells.
Volume: 28
Pages: 1661-73
Related Report
Peer Reviewed
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[Journal Article] Regulation of adult neural progenitor cells by Galectin-1/beta1 Integrin interaction2010
Author(s)
Sakaguchi, M., Imaizumi, Y., Shingo, T., Tada, H., Hayama, K., Yamada, O., Morishita, T., Kadoya, T., Uchiyama, N., Shimazaki T, Kuno, A., Poirier, F., Hirabayashi, J., Sawamoto, K., & Okano, H.
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Journal Title
J. Neurochem.
Volume: 113
Pages: 1516-24
Related Report
Peer Reviewed
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