Rejuvenation of neural stem cells

• Project/Area Number: 22500339
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Keio University
• Principal Investigator: SHIMAZAKI Takuya 慶應義塾大学, 医学部, 講師 (00324749)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 神経幹細胞 / 初期化 / 分化 / 神経細胞 / グリア / lncRNA / 再生 / ES細胞 / 転写制御因子 / Coup-TFI/II

Research Abstract

We attempted to identify the factors, which regulate plasticity of early embryonic neural stem cells and can rejuvenate late embryonic and adult neural stem cells to be early ones with high plasticity. In the result, we have identified three longon-cordin

Research Products

• [Journal Article] FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells. (2010)
  • Author(s): Sato, T., Shimazaki T, Naka, H., Fukami, S., Satoh, Y., Okano, H., Lax, I., Schlessinger, J., & Gotoh, N.
  • Journal Title: Stem Cells. Volume: 28 Pages: 1661-73
  • Peer Reviewed
• [Journal Article] Regulation of adult neural progenitor cells by Galectin-1/beta1 Integrin interaction (2010)
  • Author(s): Sakaguchi, M., Imaizumi, Y., Shingo, T., Tada, H., Hayama, K., Yamada, O., Morishita, T., Kadoya, T., Uchiyama, N., Shimazaki T, Kuno, A., Poirier, F., Hirabayashi, J., Sawamoto, K., & Okano, H.
  • Journal Title: J. Neurochem. Volume: 113 Pages: 1516-24
  • Peer Reviewed
• [Journal Article] FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells. (2010)
  • Author(s): Sato T, et al.
  • Journal Title: Stem Cells Volume: 33 Pages: 1661-1673
  • Peer Reviewed
• [Journal Article] Regulation of adult neural progenitor cells by Galectin-1/beta1 Integrin interaction. (2010)
  • Author(s): Sakaguchi M, et al.
  • Journal Title: J Neurochem. Volume: 113 Pages: 1516-1524
  • Peer Reviewed
• [Remarks]
  • URL: http://www.okano-lab.com
• [Remarks]
  • URL: http://www.okano-lab.com