| Project/Area Number |
22500363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
|
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| Research Institution | Akita University |
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Principal Investigator |
ONO Kyoichi 秋田大学, 大学院・医学系研究科, 教授 (70185635)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
OHBA Takayoshi 秋田大学, 大学院・医学系研究科, 助教 (80431625)
村上 学 秋田大学, 大学院・医学系研究科, 准教授 (80302090)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 心臓興奮 / 伝導異常 / 自動能 / 肺静脈 / 心房細動 / ノルエピネフリン / 一過性内向き電流 / イノシトール3リン酸 / Na-Ca交換 / 不整脈 |
|---|
| Research Abstract |
Atrial fibrillation, the most common sustained arrhythmia, is believed to be triggered by ectopic electrical activity originating in the myocardial sleeves surrounding the pulmonary veins. In this study, we found that cardiomyocytes in rat pulmonary veins possessed morphological and electrophysiological properties different from those of atrial myocytes. We concluded that these properties play functional role in norepinephrine-induced spontaneous activity of pulmonary vein cardiomyocytes.
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