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Noninvasive concentration measurement of non-oxygen biding form of hemoglobin using light

Research Project

Project/Area Number 22500405
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionShizuoka University

Principal Investigator

NIWAYAMA Masatsugu  静岡大学, 工学部, 准教授 (40334958)

Co-Investigator(Renkei-kenkyūsha) KIME Ryotaro  東京医科大学, 医学部, 講師 (90366120)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords生体情報 / 計測 / ヘモグロビン / 生体計測 / 近赤外分光法 / 一酸化炭素 / 空間分解法
Research Abstract

Concentration measurement of non-oxygen binding form of hemoglobin is important for safety. In this study, we examined methods for measuring it easily and precisely using visible light and near-infrared light. We performed light propagation analysis by Monte Carlo simulation, phantom experiments, and in vivo tests. The measurements of oxy-, deoxy-, carboxy-, and methehemoglobin using developed calculation algorithm were more accuratethan that of conventional algorithm.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (36 results)

All 2013 2012 2011 2010 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (16 results) Book (1 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 1 results)

  • [Journal Article] Muscle Oxygen Saturation Heterogeneity Among Leg Muscles During Ramp Exercise2013

    • Author(s)
      S. Takagi, R. Kime, M. Niwayamaet al
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 765 Pages: 273-278

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optimalfilter bandwidth for pulse oximetry2013

    • Author(s)
      N. Stuban and M. Niwayama
    • Journal Title

      Review of Scientific Instruments

      Volume: 83 Issue: 10 Pages: 1047081-5

    • DOI

      10.1063/1.4759491

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muscle Oxygen Saturation Heterogeneity Among Leg Muscles During Ramp Exercise2013

    • Author(s)
      Shun Takagi
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 765 Pages: 273-8

    • DOI

      10.1007/978-1-4614-4989-8_38

    • ISBN
      9781461447719, 9781461449898
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal filter bandwidth for pulse oximetry2012

    • Author(s)
      N. Stuban and M. Niwayama
    • Journal Title

      Rev. Sci. Instrum

      Volume: 83

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Error factors in oxygenation measurement using continuous wave and spatially resolved near infrared spectroscopy2012

    • Author(s)
      M. Niwayama, H. Suzuki, T. Yamashita, and Y. Yasuda
    • Journal Title

      The Journal of Japanese College of Angiology

      Volume: 52 Pages: 211-215

    • NAID

      130004903391

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phantom with Pulsatile Arteries to Investigate the Influence of Blood Vessel Depth on Pulse Oximeter Signal Strength2012

    • Author(s)
      N.Stuban, M.Niwayama, et al.
    • Journal Title

      Sensors

      Volume: 12 Issue: 1 Pages: 895-904

    • DOI

      10.3390/s120100895

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The use of muscle near-infrared spectroscopy in sport, health, and medical sciences: recent developments2011

    • Author(s)
      T. Hamaoka, K. McCully, M. Niwayama, B. Chance
    • Journal Title

      Philos. Trans. R. Soc. A-Math. Phys. Eng. Sci.(PHILOS T R SOC A)

      Volume: 369 Pages: 4591-4604

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of ramp bicycle exercise on exhaled carbon monoxide in humans2011

    • Author(s)
      Y. Yasuda, T. Ito, M. Miyamura, and M. Niwayama
    • Journal Title

      J. Physiol. Sci

      Volume: 201143 Issue: 4 Pages: 1-8

    • DOI

      10.1007/s12576-011-0145-z

    • NAID

      10029323482

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The use of muscle near-infrared spectroscopy in sport, health, and medical sciences : recent development2011

    • Author(s)
      T.Hamaoka, M.Niwayama, et al
    • Journal Title

      Phil.Trans.R.Soc.A

      Volume: 369 Pages: 4591-4604

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of ramp bicycle exercise on exhaled carbon monoxide in humans2011

    • Author(s)
      Y.Yasuda, M.Niwayama, et al
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 201143 Pages: 1-8

    • NAID

      10029323482

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous determination of absorption coefficients for skin and muscle tissues using spatially resolved measurements2011

    • Author(s)
      H.Suzuki, M.Niwayama, et al
    • Journal Title

      Advanced Materials Research

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accurate and fast estimation of optical properties using optical path length and spatially resolved reflectance measurement2011

    • Author(s)
      T.Yamashita, M.Niwayama, et al.
    • Journal Title

      Advanced Materials Research

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous de- termination of absorption coefficients for skin and muscle tissues using spatially resolved measurements2010

    • Author(s)
      H. Suzuki, M. Niwayama
    • Journal Title

      Advanced Materials Research

      Volume: 222 Pages: 309-312

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unchanged muscle deoxygenation heterogeneity during bicycle exercise after 6 week endurance training2010

    • Author(s)
      R. Kime, M. Niwayamaet al.
    • Journal Title

      Advances in Experimental Medi- cine and Biology

      Volume: 662 Pages: 353-358

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unchanged muscle deoxygenation heterogeneity during bicycle exercise after 6 week endurance training2010

    • Author(s)
      R.Kime, M.Niwayama, et al.
    • Journal Title

      Adv.Exp.Bio.Med.

      Volume: 662 Pages: 353-358

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Phantom experiments and simulation for transabdominal fetal pulse oximetry2012

    • Author(s)
      T. Iwano
    • Organizer
      IEEE Student Branch Young Researchers workshop 2012
    • Place of Presentation
      Hamamatsu, Japan
    • Year and Date
      2012-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Measurement of optical properties of deep muscle tissue using spatially resolved NIRS2012

    • Author(s)
      Y. Kobayashi
    • Organizer
      IEEE Student Branch Young Researchers workshop 2012
    • Place of Presentation
      Hamamatsu, Japan
    • Year and Date
      2012-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Design and Electrochemical Characterization of Polyimide Based Sub- dural Grid Electrodes for Minimally-Invasive Implantation2012

    • Author(s)
      M. Kimura
    • Organizer
      IEEE EMBS International Conference 2012
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2012-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Measurement sensitivity of deep artery on transabdominal fetal pulse oximetry2012

    • Author(s)
      M. Niwayama
    • Organizer
      IEEE EMBS International Conference 2012
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2012-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Theoretical and experi- mental study for determination of charac- teristics of bone tissue using diffuse reflectance2012

    • Author(s)
      D. Wakabayashi
    • Organizer
      IEEE EMBS International Conference 2012
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2012-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Wireless pulse oximeter for fetal application2012

    • Author(s)
      N. Stuban
    • Organizer
      ITC-CSCC 2012 conference
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2012-07-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 近赤外光による生体組織性状計測の高度化と応用2011

    • Author(s)
      庭山 雅嗣
    • Organizer
      計測自動制御学会光波応用研究会
    • Place of Presentation
      浜松
    • Year and Date
      2011-12-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 近赤外光による生体組織性状計測の高度化と応用2011

    • Author(s)
      庭山雅嗣
    • Organizer
      計測自動制御学会光波応用研究会
    • Place of Presentation
      静岡大学(浜松)(招待講演)
    • Year and Date
      2011-12-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Reducing power consumption of wireless pulse oximeters2011

    • Author(s)
      N.Stuban, M.Niwayama
    • Organizer
      5th European Conference of the International Federation for Medical and Biological Engineering
    • Place of Presentation
      Budapest Congress & World Trade Center (Budapest, Hungary)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Reducing power consumption of wireless pulse oximeters2011

    • Author(s)
      N. Stuban
    • Organizer
      5th European Conference of the International Federation for Medical and Biological Engineering
    • Place of Presentation
      Budapest, Hungary
    • Year and Date
      2011-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] NIRSの定量性・測定精度向上の試み2010

    • Author(s)
      庭山雅嗣
    • Organizer
      17回医用近赤外線分光法研究会
    • Place of Presentation
      旭川
    • Year and Date
      2010-10-16
    • Related Report
      2012 Final Research Report
  • [Presentation] NIRSの定量性・測定精度向上の試み2010

    • Author(s)
      庭山雅嗣
    • Organizer
      第17回医用近赤外線分光法研究会
    • Place of Presentation
      旭川グランドホテル
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Accurate determination of optical properties using spatially resolved measurement and laser rangefinder2010

    • Author(s)
      T. Yamashita
    • Organizer
      7th International Conference on Optics-photonics Design & Fabrication (ODF '10)
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2010-08-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Wireless pulse oximeter for fetal application

    • Author(s)
      N. Stuban
    • Organizer
      ITC-CSCC 2012 conference
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Measurement sensitivity of deep artery on transabdominal fetal pulse oximetry

    • Author(s)
      M. Niwayama
    • Organizer
      IEEE EMBS International Conference 2012
    • Place of Presentation
      Hilton Bayfront (San Diego, USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Theoretical and experimental study for determination of characteristics of bone tissue using diffuse reflectance

    • Author(s)
      D. Wakabayashi
    • Organizer
      IEEE EMBS International Conference 2012
    • Place of Presentation
      Hilton Bayfront (San Diego, USA)
    • Related Report
      2012 Annual Research Report
  • [Book] Application of Near Infrared Spectroscopy in Biomedicine (Handbook of Modern Biophysics)2013

    • Author(s)
      M. Niwayama
    • Publisher
      Springer
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Patent(Industrial Property Rights)] 光学的測定装置、光学的測定方法、及び光学的測定プログラムを格納した記憶媒体2012

    • Inventor(s)
      庭山 雅嗣
    • Industrial Property Rights Holder
      静岡大学
    • Acquisition Date
      2012-08-17
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 光学的測定装置2012

    • Inventor(s)
      庭山雅嗣
    • Industrial Property Rights Holder
      静岡大学
    • Filing Date
      2012-02-23
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 光学的測定装置2011

    • Inventor(s)
      庭山 雅嗣、金山 尚裕、鈴木 一有
    • Industrial Property Rights Holder
      静岡大学、浜松医科大学
    • Industrial Property Number
      2011-037444
    • Filing Date
      2011-02-23
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 光学的測定装置2011

    • Inventor(s)
      庭山雅嗣
    • Industrial Property Rights Holder
      静岡大学
    • Industrial Property Number
      2011-037444
    • Filing Date
      2011-02-23
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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