| Project/Area Number |
22500427
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
|
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| Research Institution | Okayama University |
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Principal Investigator |
YAMAMOTO Yumiko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20403496)
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| Research Collaborator |
OGUMA Keiji 岡山大学, 大学院・医歯薬学総合研究科, 特命教授
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ボツリヌス毒素 / 腸管 / 薬物送達 / 細菌 / 薬物送達システム |
|---|
| Research Abstract |
In food-borne botulism, the orally ingested botulinum neurotoxins, which could be classified into seven types (A to G) based on their antigenicity, must be absorbed from the small intestine. In this study, we produced the liposomes modified with HA, which is a non-toxic component of the type A botulinum toxin complex, in order to develop novel intestine-targeted drug delivery systems. On the other hand, we showed that the type E botulinum toxin might bind to the intestinal cells via the Hc domain of neurotoxin.
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