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The analysis of tissueand subtype-specificity for preventing obesity and NAFLD

Research Project

Project/Area Number 22500689
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionNational Institute of Health and Nutrition

Principal Investigator

YAMAZAKI Tomomi  独立行政法人国立健康・栄養研究所, 栄養研究所・基礎栄養研究部, 室長 (00218439)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords生活習慣病 / 脂肪肝 / リポプロテインリパーゼ / 高脂肪食 / 飽和脂肪酸 / 転写因子
Research Abstract

Saturated fatty acid-rich oil induced fatty liver in mice, and this was triggered initially by an increase in PPARγ2 protein in the liver, which led to increased expression of lipogenic genes. Inactivation of PPARγ2 may improve fatty liver induced by saturated fat. Postprandial hypertriglyceridemia in mice is induced by decreased LPL activity after fat load and is associated with obesity induced by a high-fat diet

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (18 results)

All 2013 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (8 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] The ddY mouse: a model of postprandial hypertriglyceridemia in response to dietary fat2012

    • Author(s)
      Yamazaki T, Kishimoto K, Ezaki O
    • Journal Title

      J Lipid Res

      Volume: 53(10) Issue: 10 Pages: 2024-2037

    • DOI

      10.1194/jlr.m023713

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary β-conglycinin prevents fatty liver induced by a high-fat diet by a decrease in peroxisome proliferator-activated receptor γ 2 protein2012

    • Author(s)
      Yamazaki T, Kishimoto K, Miura S, Ezaki O
    • Journal Title

      J Nutr. Biochem

      Volume: 23(2) Issue: 2 Pages: 123-132

    • DOI

      10.1016/j.jnutbio.2010.11.006

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ole of DNA methylation in the regulation of lipogenicglycerol-3-phosphate acyltransferase 1 gene expression in the mouse neonatal liver2012

    • Author(s)
      Ehara T, Kamei Y, Takahashi M, Yuan X, Kanai S, Tamura E, Tanaka M, Yamazaki T, Miura S, Ezaki O, Suganami T, Okano M, and Ogawa Y
    • Journal Title

      Diabetes

      Volume: 61(10) Issue: 10 Pages: 2442-2450

    • DOI

      10.2337/db11-1834

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] An increase in liver PPARg2 is an initial event to induce fatty liver inresponse to a diet high in butter: PPARg2 knockdown improves fatty liver induced by high-saturated fat2011

    • Author(s)
      Yamazaki T, Shiraishi S, Kishimoto K, Miura S, Ezaki O
    • Journal Title

      J Nutr. Biochem

      Volume: 22(6) Issue: 6 Pages: 543-553

    • DOI

      10.1016/j.jnutbio.2010.04.009

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle2011

    • Author(s)
      Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, EzakiO, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T
    • Journal Title

      Cell Metab

      Volume: 13(3) Issue: 3 Pages: 294-307

    • DOI

      10.1016/j.cmet.2011.01.018

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary β-conglycinin prevents fatty liver induced by a high-fat diet by a decrease in peroxisome proliferator-activated receptor γ2 protein2011

    • Author(s)
      Yamazaki T
    • Journal Title

      J Nutr Biochem

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter : PPARγ2 knockdown improves fatty liver induced by high-saturated fat2011

    • Author(s)
      Yamazaki T
    • Journal Title

      J Nutr Biochem

      Pages: 543-553

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle2011

    • Author(s)
      Kubota T
    • Journal Title

      Cell Metab

      Volume: 13 Pages: 294-307

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 大豆蛋白質β-コングリシニンの高脂肪食による脂肪肝発症予防機序2012

    • Author(s)
      山崎聖美、江崎治
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都(京都)
    • Year and Date
      2012-10-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 魚油と大豆タンパクの体内脂肪蓄積予防機序の違い2012

    • Author(s)
      山崎聖美、江崎治
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都(京都
    • Year and Date
      2012-10-11
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス新生仔の肝臓における脂肪合成酵素GPAT1のDNAメチル化による遺伝子発現制御2012

    • Author(s)
      江原逹弥、亀井康富、高橋真由美、袁勲梅、金井紗綾香、田村江梨奈、田中都、山崎聖美、三浦進司、江崎治、菅波孝祥、岡野正樹、小川佳宏
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都(京都)
    • Year and Date
      2012-10-11
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス新生仔肝臓の脂肪合成遺伝子のDNAメチル化制御2012

    • Author(s)
      亀井康富、江原逹弥、高橋真由美、袁勲梅、金井紗綾香、山崎聖美、江崎治、菅波孝祥、岡野正樹、小川佳宏
    • Organizer
      第66回日本栄養・食糧学会大会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2012-05-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 新生仔肝臓の脂肪合成遺伝子のDNAメチル化制御2012

    • Author(s)
      亀井康富、江原逹弥、高橋真由美、袁勲梅、金井紗綾香、山崎聖美、江崎治、菅波孝祥、岡野正樹、小川佳宏
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      2012-03-25
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 飽和脂肪酸過剰摂取による脂肪肝発症は肝臓PPARγ2発現ノックダウンにより予防できる2010

    • Author(s)
      山崎聖美、江崎治
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      前橋テルサ(群馬)
    • Year and Date
      2010-10-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 飽和脂肪酸過剰摂取による脂肪肝発症は肝臓PPARγ2発現ノックダウンにより予防できる2010

    • Author(s)
      山崎聖美
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      前橋テルサ(群馬県)
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 魚油と大豆タンパクの体内脂肪蓄積予防機序の違い

    • Author(s)
      山崎 聖美
    • Organizer
      第33回日本肥満学会
    • Place of Presentation
      ホテルグランヴィア京都(京都市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] Peroxisome Proliferator-Activated Receptors(PPARs)2013

    • Author(s)
      Yamazaki T, Ezaki O
    • Publisher
      Humana Press
    • Related Report
      2012 Final Research Report
  • [Book] Peroxisome Proliferator-Activated Receptors(PPARs)2013

    • Author(s)
      Yamazaki T
    • Total Pages
      343
    • Publisher
      Humana Press
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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