Suppression of colon tumorigenesis by Ah receptor

• Project/Area Number: 22501001
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Carcinogenesis
• Research Institution: Research Institute for Clinical Oncology, Saitama Cancer Center
• Principal Investigator: IKUTA Togo 埼玉県立がんセンター(臨床腫瘍研究所), 研究員 (00262072)
• Co-Investigator(Renkei-kenkyūsha): KAWAJIRI Kaname 埼玉がんセンター, 臨床腫瘍研究所, 研究員 (50142112) ; KOBAYASHI Yasuhito 埼玉県立循環器病センター (80425652) ; KOIKE Manabu 放射線医学総合研究所, 研究員 (70280740)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 炎症 / 大腸癌 / Ah レセプター / Ahレセプター / 大腸がん / サイトカイン / β-catenin / 三次元培養 / 盲腸

Research Abstract

Tumor suppressor function of Ah receptor(AhR) was shown by spontaneously developed cecal tumor in AhR-deficient mice. In order to investigate the role of AhR, we studied the production of inflammatory cytokines. Concentration of IL-1β and IL-6 produced in AhR-/- mice was significantly higher than AhR-/-・ASC-/- double mutated mice which showed reduced cecal carcinogenesis. We developed co-culture system constituted with colonic epithelial cells and macrophages and examined production of cytokines into the culture medium.

Research Products

• [Journal Article] ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice (2013)
  • Author(s): Togo Ikuta
  • Journal Title: Carcinogenesis Volume: 印刷中 Issue: 7 Pages: 1620-1627
  • DOI: 10.1093/carcin/bgt083
  • Peer Reviewed
• [Journal Article] Association of germline or somatic TP53 missense mutation with oncogene amplification in tumors developed in patients with Li-Fraumeni or Li-Fraumeni-like syndrome. (2011)
  • Author(s): Sugawara W, Arai Y, Kasai F, Fujiwara Y, Haruta M, Hosaka R, Nishida K, Kurosumi M, Kobayashi Y, Akagi K, Kaneko Y
  • Journal Title: Genes Chromosomes Cancer Volume: 50(7) Pages: 535-545
• [Journal Article] Pathological tumor response to neoadjuvant chemotherapy using anthracycline and taxanes in patients with triple-negative breast cancer (2011)
  • Author(s): Sakuma K, Kurosumi M, Oba H, Kobayashi Y, Takei H, Inoue K, Tabei T, Oyama T
  • Journal Title: Exp Ther Med Volume: 2(2) Pages: 257-264
• [Journal Article] B lymphocyte-induced maturation protein 1 is a novel target gene of aryl hydrocarbon receptor (2010)
  • Author(s): Ikuta, T
  • Journal Title: J Dermatol Sci Volume: 58 Pages: 211-216
  • NAID: 10027401221
• [Journal Article] B lymphocyte-induced maturation protein 1 is a novel target gene of aryl hydrocarbon receptor (2010)
  • Author(s): Ikuta T.
  • Journal Title: Journal of Dermatological Science Volume: 58 Pages: 211-216
  • NAID: 10027401221
  • Peer Reviewed
• [Journal Article] ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice
  • Author(s): Ikuta, T
  • Journal Title: Carcinogenesis
• [Presentation] ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice. (2012)
  • Author(s): 生田統悟
  • Organizer: チトクロムP450 発見50 周年記念シンポジウム
  • Place of Presentation: 九州大学コラボステーション
  • Year and Date: 2012-12-03
• [Presentation] ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice (2012)
  • Author(s): 生田統悟
  • Organizer: チトクロムP450 発見50 周年記念シンポジウム
  • Place of Presentation: 九州大学コラボステーション
  • Year and Date: 2012-12-03
• [Presentation] ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice (2012)
  • Author(s): Togo Ikuta
  • Organizer: チトクロムP４５０発見５０周年記念シンポジウム
  • Place of Presentation: 九州大学コラボステーション
  • Invited