| Project/Area Number |
22501006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Jobu University (2012)
Tokyo Medical and Dental University (2010-2011) |
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Principal Investigator |
ABE Mayumi 上武大学, 看護学部・医学生理学研究所, 教授 (80271980)
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Ikuo 東京医科歯科大学, 大学院・医歯(薬)総合研究科, 教授 (60100129)
YOSHIDA Tomoko 東京医科歯科大学, 大学院・医歯(薬)総合研究科, 寄付講座教員 (40401369)
|
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Yasufumi 東北大学, 加齢医学研究所, 教授 (50178779)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 血管新生 / ピグペン / PILSAP / 血管内皮細胞 / 胚性幹細胞 / 血管内皮前駆細胞 / アミノペプチダーゼ / VEGF / 分化 / 腫瘍血管新生 / 血管新生制御 |
|---|
| Research Abstract |
While the authors investigated how PILSAP, which we found as an angiogenic factor as well as a vasculogenic one, a nuclear protein Pigpen was thought to play a certain role there. The inhibition of Pigpen expression by siRNA showed that pigpen was involved in angiogenesis and vasculogenesis. Moreover, VEGF (vascular endothelial growth factor) increased PILSAP-pigpen complex formation by mobilization of PILSAP from cytoplasm to nucleus. Our study demonstrates that PILSAP may cooperate with pigpen to induce angiogenesis and vasculogenesis
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