Analysis of mechanisms for immunosuppression through ILT7/NKp44/BDCA2 ligands expressed on cancer cells

• Project/Area Number: 22501025
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Tumor immunology
• Research Institution: Keio University
• Principal Investigator: TSUKAMOTO Nobuo 慶應義塾大学, 医学部, 助教 (20407117)
• Co-Investigator(Kenkyū-buntansha): KAWAKAMI Yutaka 慶應義塾大学, 医学部, 教授 (50161287)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 免疫抑制 / プラズマ細胞様樹状細胞 / ILT7 / NKp44 / BDCA2

Research Abstract

To clarify the mechanisms of immunosuppression through ILT7/NKp44/BDCA2 ligands expressed on cancer cells, we tried to identify these ligands molecularly and successfully cloned the NKp44L. Furthermore, we showed a signal pathway, which could control the

Research Products

• [Journal Article] CCL2 is critical for immunosuppression to promote cancer metastasis. (2013)
  • Author(s): Kudo-Saito C, Shirako H, Ohike M, Tsukamoto N, Kawakami Y.
  • Journal Title: Clin Exp Metastasis Volume: 30 Pages: 393-405
  • Peer Reviewed
• [Journal Article] CCL2 is critical for immunosuppression to promote cancer metastasis (2013)
  • Author(s): Kudo-Saito C.
  • Journal Title: Clin Exp Metastasis Volume: 30 Issue: 4 Pages: 393-405
  • DOI: 10.1007/s10585-012-9545-6
  • Peer Reviewed
• [Journal Article] Immune suppression and resistance mediated by constitutive activation of Wnt/β-catenin signaling in human melanoma cells. (2012)
  • Author(s): Yaguchi T, Goto Y, Kido K, Mochimaru H, Sakurai T, Tsukamoto N, Kudo-Saito C, Fujita T, Sumimoto H, Kawakami Y.
  • Journal Title: J Immunol. Volume: 189 Pages: 2110-2117
  • Peer Reviewed
• [Journal Article] Cancer-testis antigen BORIS is a novel prognostic marker for patients with esophageal cancer. (2012)
  • Author(s): Okabayashi K, Fujita T, Miyazaki J, Okada T, Iwata T, Hirao N, Noji S, Tsukamoto N, Goshima N, Hasegawa H, Takeuchi H, Ueda M, Kitagawa Y, Kawakami Y.
  • Journal Title: Cancer Sci. Volume: 103 Pages: 1617-1624
  • Peer Reviewed
• [Journal Article] Immunotherapy targeting cancer stem cells. (2012)
  • Author(s): Kawakami Y, Matsushita M, Ueda R, Tsukamoto N, Ohta S.
  • Journal Title: Nihon Rinsho Volume: 70 Pages: 2142-6
  • NAID: 40019493388
• [Journal Article] Immune suppression and resistance mediated by constitutive activation of Wnt/β-catenin signaling in human melanoma cells (2012)
  • Author(s): Yaguchi T.
  • Journal Title: J Immunol. Volume: 189 Issue: 5 Pages: 2110-2117
  • DOI: 10.4049/jimmunol.1102282
  • Peer Reviewed
• [Journal Article] Cancer-testis antigen BORIS is a novel prognostic marker for patients with esophageal cancer. (2012)
  • Author(s): Okabayashi K, Fujita T, Miyazaki J, Okada T, Iwata T, Hirao N, Noji S, Tsukamoto N, Goshima N, Hasegawa H, Takeuchi H, Ueda M, Kitagawa Y, Kawakami Y.
  • Journal Title: Cancer Sci Volume: 103(9) Issue: 9 Pages: 1617-24
  • DOI: 10.1111/j.1349-7006.2012.02355.x
  • Peer Reviewed
• [Journal Article] Immunotherapy targeting cancer stem cells (2012)
  • Author(s): Kawakami Y.
  • Journal Title: Nihon Rinsho Volume: 70 Pages: 2142-2146
  • NAID: 40019493388
• [Journal Article] The mechanisms of cancer immunoescape and development of overcoming strategies. (2011)
  • Author(s): Yaguchi T, Sumimoto H, Kudo-Saito C, Tsukamoto N, Ueda R, Iwata-Kajihara T, Nishio H, Kawamura N, Kawakami Y.
  • Journal Title: Int J Hematol. Volume: 93 Pages: 294-300
  • NAID: 10029533724
• [Presentation] Augmentation of anti-tumor immune responses by Kampo medicine compound which inhibits signaling associated with cancer induced immunosuppression (2012)
  • Author(s): Kamijuku H, 1 名, Tsukamoto N, 4 名,Kawakami Y.
  • Organizer: 2012 年日本免疫学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2012-12-07
• [Presentation] Identification of human melanoma antigen with favorable characteristics for the use in immunotherapy (2012)
  • Author(s): Tsukamoto N, 3 名, Kawakami Y.
  • Organizer: 2012 年日本免疫学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2012-12-06
• [Presentation] Roles of aryl hydrocarbon receptor (AhR) in cancer progression in tumor microenvironment (2012)
  • Author(s): Tsukamoto N, 4名, Kawakami Y.
  • Organizer: 2012年日本癌学会
  • Place of Presentation: ロイトン札幌
  • Year and Date: 2012-09-21
• [Presentation] New diagnostic and therapeutic target KU-MEL9 for chronic myeloid leukemia (CML) (2012)
  • Author(s): Matsushita M, 3 名, Tsukamoto N,Kawakami Y, 3 名.
  • Organizer: AACR Anual Meeting2012
  • Place of Presentation: Chicago USA
  • Year and Date: 2012-04-02
• [Presentation] Roles of aryl hydrocarbon receptor (AhR) in cancer progression in tumor microenvironment (2012)
  • Author(s): Nobuo Tsukamoto
  • Organizer: 第７１回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌他（札幌市）
• [Presentation] Identification of human melanoma antigen with favorable characteristics for the use in immunotherapy (2012)
  • Author(s): Nobuo Tsukamoto
  • Organizer: 第４１回日本免疫学会総会・学術集会
  • Place of Presentation: 神戸国際会議場他（神戸市）
• [Presentation] Augmentation of anti-tumor immune responses by Kampo medicine compound which inhibits signaling associated with cancer induced immunosuppression (2012)
  • Author(s): Hajime Kamijuku
  • Organizer: 第４１回日本免疫学会総会・学術集会
  • Place of Presentation: 神戸国際会議場他（神戸市）
• [Presentation] New diagnostic and therapeutic target KU-MEL9 for chronic myeloid leukemia (CML) (2012)
  • Author(s): Maiko Matsushita
  • Organizer: AACR Anual Meeting 2012
  • Place of Presentation: Chicago
• [Presentation] IDO-catabolized tryptophan metabolite may be involved in the generation of immunosuppressive tumor microenvironment through induction of Treg via AhR activation (2011)
  • Author(s): Komuro M, Tsukamoto N, 1名, Kawakami Y.
  • Organizer: 2011年日本免疫学会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2011-11-28
• [Presentation] トリプトファン代謝産物による芳香族炭化水素受容体を介したがん免疫抑制 (2011)
  • Author(s): 小室美紗、塚本信夫, 他2名
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-28
• [Presentation] Enhanced metastasis through immunosuppressive cancer microenvironment and its control by targeting signaling molecules (2011)
  • Author(s): Kawakami Y, 2 名, Tsukamoto N, 4 名.
  • Organizer: 2011年日本癌学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-04
• [Presentation] がん微小環境免疫抑制病態による転移促進とその制御 (2011)
  • Author(s): 河上裕、工藤、住本、塚本信夫, 他4名
  • Organizer: 第70回日本癌学会学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県)(招待講演)
  • Year and Date: 2011-10-04
• [Presentation] Involvement of CCL22/CCR4 in lymph node metastasis of human head and neck cancer via increasing invasion ability (2011)
  • Author(s): Tsujikawa T, 3名, Tsukamoto N, 4名,Kawakami Y.
  • Organizer: 2011年日本癌学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-03
• [Presentation] CCL22/CCE4は癌細胞浸潤能増加によりヒト頭頸部扁平上皮癌のリンパ節転移に関与する (2011)
  • Author(s): 辻川敬裕、谷口、小林、植田、塚本信夫, 他5名
  • Organizer: 第70回日本癌学会学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-03
• [Presentation] がん免疫逃避機構とその制御 (2011)
  • Author(s): 河上裕, 6名, 塚本信夫
  • Organizer: 2011 年日本がん免疫学会
  • Place of Presentation: 千里ライフサイエンスセンター
  • Year and Date: 2011-07-01
• [Presentation] Immune escape of Snail/Slug induced EMT cancer cells through down-regulation of MICA and MICB (2010)
  • Author(s): Tsukamoto N, 3名, Kawakami Y.
  • Organizer: 2010年日本癌学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] NKp44 ligand expression on cancer cells is down-regulated by EMT (2010)
  • Author(s): Ida Y., Tsukamoto N, 6名, Kawakami Y.
  • Organizer: 2010年日本癌学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] NKp44 ligand expression on cancer cells is down-regulated by EMT. (2010)
  • Author(s): 井田陽介、塚本信夫, 他7名
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24
• [Presentation] Cancer-testis antigen BORIS is a novel prognostic marker for patients with esophageal cancer (2010)
  • Author(s): Okabayashi K, 6名, Tsukamoto N, 4名,Kawakami Y.
  • Organizer: 2010年日本癌学会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-23
• [Presentation] がん免疫逃避機構とその制御 (2010)
  • Author(s): 河上裕, 2名, 塚本信夫, 4名
  • Organizer: 2010 年日本がん免疫学会
  • Place of Presentation: KKRホテル熊本
  • Year and Date: 2010-07-23
• [Patent(Industrial Property Rights)] がん免疫療法 (2012)
  • Inventor(s): 塚本信夫、松下麻衣子、服部豊、河上裕
  • Industrial Property Rights Holder: 塚本信夫、松下麻衣子、服部豊、河上裕
  • Industrial Property Number: 2012-132288
  • Filing Date: 2012-06-11