Development of DDS which accumulate cancer cell by chemokines function in peritoneal carcinomatosis therapy
| Project/Area Number |
22501042
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical oncology
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| Research Institution | University of Toyama |
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Principal Investigator |
KOIZUMI Keiichi 富山大学, 和漢医薬学総合研究所, 准教授 (10334715)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
SAKURAI Hiroaki 富山大学, 和漢医薬学総合研究所, 准教授 (00345571)
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|---|
| Co-Investigator(Renkei-kenkyūsha) |
SAIKI Ikuo 富山大学, 和漢医薬学総合研究所, 教授 (80133776)
FUKUOKA Junya 富山大学, 大学病院, 准教授 (00324575)
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|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ドラッグデリバリー / ケモカイン / がん細胞 / 遊走 / 方向性 / がん |
|---|
| Research Abstract |
We examined expression of several chemokine receptors in human solid cancer such as gastric, colorectal, liver, ovarian cancer cell lines. These cell lines selectively expressed CXCR4 at high levels. These cells showed significant chemotactic response to CXCL12 in Boyden chemotaxis chamber. However, this response could not be observed in Real-time migration activity monitoring device. On the other hand, flexibility of the kineticism of these cells increased.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Chemokine CXCL16 suppresses liver metastasis of colorectal cancer via augmentation of tumor-infiltrating NKT cells in a murine model2013
Author(s)
Ji-Ye Kee, Aya Ito, Shozo Hojo, Isaya Hashimoto, Yoshiko Igarashi, Kazuhiro Tsukada, Tatsuro Irimura, Naotoshi Shibahara, Takashi Nakayama, Osamu Yoshie, Hiroaki Sakurai, Ikuo Saiki and Keiichi Koizumi
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Journal Title
Oncol.Rep
Volume: 29
Pages: 975-82
Related Report
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[Journal Article] Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer2012
Author(s)
Kudo Y, Iizuka S, Yoshida M, Nguyen PT, Siriwardena SB, Tsunematsu T, Ohbayashi M, Ando T, Hatakeyama D, Shibata T, Koizumi K, Maeda M, Ishimaru N, Ogawa I, Takata T
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Journal Title
NAID
Related Report
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