| Project/Area Number |
22501051
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical oncology
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| Research Institution | Showa University |
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Principal Investigator |
SIRAI Takao 昭和大学, 医学部, 助教 (90384362)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAOKA Toshimitsu 昭和大学, 腫場分子生物学研究所, 講師 (40384359)
OHMORI Tohru 昭和大学, 腫場分子生物学研究所, 准教授 (10276529)
HIROSE Takashi 昭和大学, 医学部, 准教授 (40307038)
KADOKURA Mitsutaka 昭和大学, 医学部, 教授 (60214417)
ADACHI Mitsuru 昭和大学, 医学部, 教授 (10095870)
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| Project Period (FY) |
2010-10-20 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 喫煙者肺癌 / 扁平上皮肺癌 / 肺扁平上皮癌 / 喫煙 / 上皮成長因子受容体 / ADAM17 / EGFR / 肺癌 / 扁平上皮癌 |
|---|
| Research Abstract |
Epidermal growth factor receptor (EGFR) overexpression and aberrant activation are frequently identified in non small cell lung carcinoma (NSCLC). Although EGFR-targeted therapies (i.e.: EGFR-TKIs, and anti-EGFR antibody) are used, the prognosis of NSCLC remains poor. ADAM17 induces activation of EGFR through EGF-like ligand cleavage. We hypothesized that the inflammatory cytokines and EGF-like ligands might up-regulate the expression of EGFR via ADAM17, leading to the resistance to EGFR-TKIs in squamous cell carcinoma of lung. These findings promisingly indicate additional therapeutic strategies and the understanding of tumorigenesis for NSCLC.
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