Pathogenic mechanism of inflammatory disease caused by exposure to an insect repellent

Research Project

Project/Area Number	22510072
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Risk sciences of radiation/Chemicals
Research Institution	Keio University
Principal Investigator	YOKOTA Eriko (AIZU Eriko) 慶應義塾大学, 薬学部, 講師 (10222457)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	トキシコロジー / 炎症反応 / アレルギー / 化学物質過敏症 / シグナル伝達 / 防虫剤・殺虫剤 / 炎症 / アレルギー・ぜんそく / 昆虫忌避剤 / マスト細胞
Research Abstract	DEET (N,N-diethyl-m-toluamide) and pyrethroids are widely used as insect repellents in households. Exposure to these chemicals may induce sick building syndrome or inflammatory diseases, however, its pathogenic mechanism is not well known. In the present

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