| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
1. The protective effects of water-soluble derivatives of flavonoids on photo- and gamma ray-induced DNA double-strand breaks were evaluated in a quantitative manner. This observation demonstrated the dependence of the antioxidant potentials of these compounds on the source of irradiation. 2. It was found that tetrazolato-bridged dinuclear platinum(II) complexes induced the irreversible compaction of large genomic DNA, which was accompanied by a change in the secondary structure from the B to C form. 3.The appearance of the phase-segregated state in megabase-size DNA is markedly different from the all-or-none characteristics on the foldingtransition in a single sub-megabase-size DNA. 4. Novel stereoisomers of tetravalent polyamines were examined their ability to induce the compaction of single DNA molecules. It was found that Isomer (R,S-R,S) is more potent at inducing both DNA compaction and changes in the secondary structure.
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