| Project/Area Number |
22510240
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Living organism molecular science
|
|---|
| Research Institution | Kyoto Pharmaceutical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Masayuki 京都薬科大学, 薬学部, 教授 (90116129)
NAKAMURA Seikou 京都薬科大学, 薬学部, 助教 (20411035)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | アーユルベヴェーダ生薬 / PPAR / メトキシフラボノール / アポルフィン型アルカロイド / アーユルヴェーダ生薬 / 生薬 / 生活習慣病 / 糖尿病 / 辛味成分 / フラボノール / クロロゲン酸誘導体 / PPARγ / 構造活性相関 / piperlonguminine / Nulumbo nucifera |
|---|
| Research Abstract |
We mainly focused on Ayurvedic traditional medicine and have researched the active constituents for therapeutics of life-style related diseases through expression of peroxisome proliferator-activated receptor (PPAR). As the results, the extracts and the constituents from therhizomes of Kaempferia parviflora, flower of Nelumbo nucifera, and amide constituents from the fruit of Piper chaba, which are cultivated in India as well as southeast Asia, were found to show PPARγ agonist-like effects in 3T3-L1 adipocytes. The active constituents, 3,5,7,3’,4’-penta- mehoxyflavonol, N-nornuciferine, piperlonguminine, and their derivatives showed enhancement of PPARγ2, C/EBPα and β mRNA, although they had less agonistic activity at PPARγ levels. Furhermore,plasma concentrations were determined after administration of piperlonguminine and retrofractamide A in mice, together with synthesis of retrofactamide A and its derivatives to find more effectiveconstituents.
|
