Measurement of intracellar antioxidant activity using organelle localized fluorescence probes
| Project/Area Number |
22550087
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Fukuoka University |
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Principal Investigator |
SHIOJI Kosei 福岡大学, 理学部, 准教授 (80291839)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 可視化 / 細胞 / 組織 / ストレス / 抗酸化 / 細胞・組織 |
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| Research Abstract |
Mitochondria are functionally important subcellular organelles; they are a major source of reactive oxygen species (ROS) in mammalian cells and are major targets of oxidative damage. Such damage to mitochondria has serious consequences such as cell death caused by the termination of energy generation. In this study, we synthesized mitochondria localized fluorescence probe having several wave lengths, and a nucleus localized hydrogen peroxide sensitive fluorescence probe. The measurement of measurement of intracellar antioxidant activity using these fluorescence probes.
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Report
(4 results)
Research Products
(36 results)
