A novel biosensing mechanism using sensor kinase activity
| Project/Area Number |
22550149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemistry related to living body
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 生体機能材料 / シグナル変換 / バイオセンシング / 電子伝達タンパク質 / センサーキナーゼ / アズリン / チトクロムc |
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| Research Abstract |
The objective of this study is to produce a novel bio-sensing mechanism constituted by sensor-kinase and signal transduction system that we proposed in previous works. Sensor-kinase is a protein which senses an external stimulus such as a simple molecule or light to phosphorylate a particular protein and regulate its activity. In this study, we attempted to transform the output of sensor-kinase to an electronic signal. We have almost achieved the initial objective by using a transcriptional regulator in place of sensor-kinase as a sensory moiety.
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Report
(4 results)
Research Products
(37 results)
