Syntheses of apatite via Ca complexes of amino acids involved innon-collagen protein
| Project/Area Number |
22550183
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Inorganic industrial materials
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| Research Institution | Kogakuin University |
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Principal Investigator |
SATO Mitsunobu 工学院大学, 基礎・教養教育部門, 教授 (10154105)
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| Research Collaborator |
HAYAKAWA Tohru 鶴見大学, 歯学部・歯学科, 教授 (40172994)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 生体材料 / 無機工業化学 / 再生医学 / 生体分子 / ナノバイオ |
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| Research Abstract |
The apatite powders having low crystallinity were prepared using Ca complexes of amino acid ligands. The strength of the matrix, apatite crystallinity and distribution affected the regeneration ability of the 3 dimensional porous scaffolds with the prepared apatites and a biodegradable polymer (PLGA). The aqueous-solution coating (ASC) method was newly developed to afford a position and shape model of apatite in scaffolds. The cell attachment and expansion of osteocalcin on the apatite f ilms having characteristic network structure by ASC method were also examined. Based on theseresults, scaffold fabrication by apatite deposition directly in gelatin was newly achieved through the complexes of amino acids involved in non-collagen protein.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Hydroxyapatite coating for titanium fibre mesh scaffold enhances osteoblast activity and bone tissue formation2012
Author(s)
Makoto Hirota, Tohru Hayakawa, Masao Yoshinari, Akihiro Ametani, Takaki Shima, Yuka Monden, Tomomichi Ozawa, Mitsunobu Sato, Chika Koyama, Naoto Tamai, Toshinori Iwai, Iwai Tohnai
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Journal Title
International Journal of Oral & Maxillofacial Surgery
Volume: 41
Pages: 1304-1309
Related Report
Peer Reviewed
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