| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
The apatite powders having low crystallinity were prepared using Ca complexes of amino acid ligands. The strength of the matrix, apatite crystallinity and distribution affected the regeneration ability of the 3 dimensional porous scaffolds with the prepared apatites and a biodegradable polymer (PLGA). The aqueous-solution coating (ASC) method was newly developed to afford a position and shape model of apatite in scaffolds. The cell attachment and expansion of osteocalcin on the apatite f ilms having characteristic network structure by ASC method were also examined. Based on theseresults, scaffold fabrication by apatite deposition directly in gelatin was newly achieved through the complexes of amino acids involved in non-collagen protein.
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