Multi-scale biomechanical system of blood flow in microcirculation
Project/Area Number |
22560155
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Fluid engineering
|
Research Institution | Chiba University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | バイオメカニクス / 血流 / 流体力学 / 固体力学 / 計算力学 |
Research Abstract |
A computer simulation of transition between tumbling andtank-treading motions of a red blood cell was carried out to determine a parameter set ofcell membrane's elastic constants and natural states that can reproduce a motiontransition observed inin vitro experiments. Apparent blood flow properties depending onmechanical interaction among red blood cells were clarified for a two-branch blood vesselmodel as well as an image-based capillary network model with two dimensionalsimulations. Through these studies, quantitative data is obtained for mechanical modelingof multiscale blood flow behaviors from a red blood cell to apparent flow behaviors inmicrocirculatory system.
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Report
(4 results)
Research Products
(27 results)