Study on NADPH oxidase function in development
| Project/Area Number |
22570140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
KAMEI Kaeko 京都工芸繊維大学, 工芸科学研究科, 教授 (00214544)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Masamitsu 京都工芸繊維大学, 工芸科学研究科, 教授 (00182460)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 昆虫 / ショウジョウバエ / NADPHオキシダーゼ / 活性酸素種 / 発生 / 翅形成 / Nox/Duox |
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| Research Abstract |
NADPH (nicotinamide adenine dinucleotide phosphate) oxidase is an enzyme that produces reactive oxygen species. The function of NADPH oxidase in the development, especially in the wing formation, was analyzed using Drosophila. We reveled that NADPH oxidase is essential for normal wing development through the melanin formation and cross-linking of tyrosine for wing sclerotization and the suppression of apoptosis. By genetic screening, the genetic region on 3 rd chromosome that could interact with dDuox (catalytic domain of NADPH oxidase) was found.
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Report
(4 results)
Research Products
(9 results)
