Role of H-ficolin. A recognition molecule in innate immunity
Project/Area Number |
22570144
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Functional biochemistry
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Research Institution | Fukushima Medical University |
Principal Investigator |
ENDO Yuichi 福島県立医科大学, 医学部, 准教授 (20117427)
|
Co-Investigator(Renkei-kenkyūsha) |
FUJITA Teizo 福島県立医科大学, 名誉教授 (20134223)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 免疫学 / 生体分子 / 蛋白質 / レクチン / 補体 / 成体分子 |
Research Abstract |
To define the role of human H-ficolin in vivo, we generated a model mouse, ficolins A/B double-deficient mouse transiently expressing H-ficolin. In the serum, H-ficolin formed the complexes with serine proteases MASPs and sMAP. H-ficolin recognized a bacterial strain, Streptococcus pneumonia D39, and led to complement activation on this bacterium. The susceptibility of this mouse to bacterial infection is in progress. These results suggest that H-ficolin is involved in first defense against bacterial infection.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] The Lectin Pathway of Complement Activation Is a Critical Component of the Innate Immune Response to Pneumococcal Infection2012
Author(s)
Ali YM, Lynch NJ, Haleem KS, Fujita T, Endo Y, Hansen S, Holmskov U, Takahashi K, Stahl GL, Dudler T, Girija UV, Wallis R, Kadioglu A, Stover CM, Andrew PW, Schwaeble WJ
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Journal Title
PLoS Pathogens
Volume: 8
Issue: 7
Pages: e1002793-e1002793
DOI
Related Report
Peer Reviewed
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[Journal Article] Guideline for Hereditary Angioedema (HAE) 2010 by the Japanese Association for Complement Research - Secondary Publication2012
Author(s)
Horiuchi T, Ohi H, Ohsawa I, Fujita T,Matsushita M, Okada N, Seya T,Yamamoto T, Endo Y, Hatanaka M,Wakamiya N, Mizuno M, Nakao M, OkadaH, Tsukamoto H, Matsumoto M, Inoue N,Nonaka M, Kinoshita T.
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Journal Title
Allergology International
Volume: 61
Issue: 4
Pages: 559-562
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed
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