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A regulation mechanism of homologous recombination by protein-protein interactions

Research Project

Project/Area Number 22570147
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional biochemistry
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

MIKAWA Tsutomu  独立行政法人理化学研究所, 遺伝制御科学特別研究ユニット, 専任研究員 (20321820)

Research Collaborator INOUE Jin  独立行政法人理化学研究所, 遺伝制御科学特別研究ユニット, 特別研究員 (10469893)
MASUDA Tokiha  独立行政法人理化学研究所, 遺伝制御科学特別研究ユニット, ジュニアリサーチアソシエイト
SHINOHARA Takeshi  独立行政法人理化学研究所, 遺伝制御科学特別研究ユニット, ジュニアリサーチアソシエイト
OKUI Saya  独立行政法人理化学研究所, 遺伝制御科学特別研究ユニット, 研修生
KASAGI Motochika  独立行政法人理化学研究所, 遺伝制御科学特別研究ユニット, 研修生
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords相同組換え / タンパク質間相互作用 / タンパク質-DNA間相互作用 / NMR / 生物物理 / 蛋白質 / 酵素反応 / 蛋白質間相互作用 / 蛋白質-核酸間相互作用 / 蛋白-核酸間相互作用
Research Abstract

Homologous recombinational repair (HRR) is an important pathway to maintain genomic stability. The RecF pathway is a bacterial HRR, in which RecA, RecF, RecO, RecR, and SSB proteins regulate HRR via their interactions. In this study, relationships between the interactions and regulation of HRR have been analyzed. As a result, a model mechanism of HRR regulation based on the protein-protein interaction was proposed.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (88 results)

All 2013 2012 2011 2010

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (66 results) Patent(Industrial Property Rights) (7 results) (of which Overseas: 3 results)

  • [Journal Article] High-resolution heteronuclear multidimensional NMR of proteins living insect cells using a baculovirus protein expression system ≪2013

    • Author(s)
      Jumpei Hamatsu, Daniel O'Donovan, Takashi Tanaka, Takahiro Shirai, Yuichiro Hourai, Tsutomu Mikawa, Teppei Ikeya, Masaki Mishima, Wayne Boucher, Brian O. Smith, Ernest D. Laue, Masahiro Shirakawa, Yutaka Ito 4
    • Journal Title

      Journal of the American Chemical Society

      Volume: 135 Issue: 5 Pages: 1688-1691

    • DOI

      10.1021/ja310928u

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] In-cell NMR of intrinsically disordered proteins in prokaryotic cells2012

    • Author(s)
      Ito, Y., Mikawa, T. & Smith, B. O.
    • Journal Title

      Methods Mol Biol

      Volume: 895 Pages: 19-31

    • DOI

      10.1007/978-1-61779-927-3_2

    • ISBN
      9781617799266, 9781617799273
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Use of Native Gels to Measure Protein Binding to SSB2012

    • Author(s)
      Inoue, J.
    • Journal Title

      Methods Mol Biol

      Volume: 922 Pages: 175-182

    • DOI

      10.1007/978-1-62703-032-8_13

    • ISBN
      9781627030311, 9781627030328
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The double-stranded break-forming activity of plant SPO11s and a novel rice SPO11 revealed by a Drosophila bioassay2012

    • Author(s)
      Yoshinori Shingu
    • Journal Title

      BMC molecular biology

      Volume: 13 Issue: 1 Pages: 1-1

    • Total Pages
      16
    • DOI

      10.1186/1471-2199-13-1

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Glucose/O2 Biofuel Cell Using Recombinant Thermophilic Enzymes2012

    • Author(s)
      Xiuyun Wang
    • Journal Title

      International Journal of ELECTROCHEMICAL SCIENCE

      Volume: 7 Pages: 1071-1078

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vital role of the second DNA-binding site of Rad52 in yeast homologous recombination2011

    • Author(s)
      Naoto Arai, Wataru Kagawa, Kengo Saito, Yoshinori Shingu, Tsutomu Mikawa, Hitoshi Kurumizaka, Takehiko Shibata
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 286 Issue: 20 Pages: 17607-17617

    • DOI

      10.1074/jbc.m110.216739

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mechanism for single-stranded DNA-binding protein (SSB) displacement from single-stranded DNA upon SSB-RecO interaction2011

    • Author(s)
      Jin Inoue
    • Journal Title

      J Biol Chem.

      Volume: 286 Issue: 8 Pages: 6720-6732

    • DOI

      10.1074/jbc.m110.164210

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enlightenment of yeast mitochondrial homoplasmy : diversified roles of gene conversion2011

    • Author(s)
      Ling, F., Mikawa, T. and Shibata, T.
    • Journal Title

      Genes (Basel)

      Volume: 2 Issue: 1 Pages: 169-190

    • DOI

      10.3390/genes2010169

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A mechanism for single-stranded DNA-binding protein (SSB) displacement from single-stranded DNA upon SSB-RecO interaction2011

    • Author(s)
      Jin Inoue
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 286 Pages: 6720-6732

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enlightenment of yeast mitochondrial homoplasmy : diversified roles of gene conversion2011

    • Author(s)
      Feng Ling
    • Journal Title

      Genes

      Volume: 2 Pages: 169-190

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMR protein structure determination in living E. coli cells using nonlinear sampling2010

    • Author(s)
      Ikeya, T., Sasaki, A., Sakakibara, D., Shigemitsu, Y., Hamatsu, J., Hanashima, T., Mishima, M., Yoshimasu, M., Hayashi, N., Mikawa, T., (他6名)
    • Journal Title

      Nat Protoc

      Volume: 5 Issue: 6 Pages: 1051-60

    • DOI

      10.1038/nprot.2010.69

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A DNA-binding surface of SPO11-1, an Arabidopsis SPO11 orthologue required for normal meiosis2010

    • Author(s)
      Shingu, Y., Mikawa, T., Onuma, M., Hirayama, T. & Shibata, T.
    • Journal Title

      FEBS J

      Volume: 277 Issue: 10 Pages: 2360-74

    • DOI

      10.1111/j.1742-4658.2010.07651.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 相同DNA組換えの機構理解から新規蛋白質創出へ2010

    • Author(s)
      柴田武彦、美川 務
    • Journal Title

      酵素工学ニュース

      Volume: 63 Pages: 16-22

    • URL

      http://www.enzyme-eng.com/modules/pico02/index.php?content_id=3

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMR protein structure determination in living E.coli cells using non-linear sampling2010

    • Author(s)
      Teppei Ikeya
    • Journal Title

      Nature Protocols

      Volume: 5 Pages: 1051-1060

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A DNA- binding surface of SPO11-1, an Arabidopsis SPO11 orthologue required for normal meiosis2010

    • Author(s)
      Yoshinori Shingu
    • Journal Title

      The FEBS journal

      Volume: 277 Pages: 2360-2374

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Regulation of Thermus Thermophilus RecA function by Recombination mediators2012

    • Author(s)
      篠原 赳
    • Place of Presentation
      淡路
    • Year and Date
      2012-12-20
    • Related Report
      2012 Final Research Report
  • [Presentation] RecA組換え酵素のL1ループの制御機能2012

    • Author(s)
      柴田武彦
    • Organizer
      第30回染色体ワークショップ
    • Place of Presentation
      淡路
    • Year and Date
      2012-12-19
    • Related Report
      2012 Final Research Report
  • [Presentation] バクテリアにおけるDNA組換え修復の制御機構2012

    • Author(s)
      美川 務
    • Organizer
      第30回染色体ワークショップ
    • Place of Presentation
      淡路
    • Year and Date
      2012-12-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Thermus thermophiles由来組換えメディエーターの分子機能解析2012

    • Author(s)
      篠原 赳
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 出芽酵母Rad51組換え酵素のN末端領域の機能2012

    • Author(s)
      新井直人
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Related Report
      2012 Final Research Report
  • [Presentation] A comparative study on homologous recombination mediators from T. thermophiles2012

    • Author(s)
      篠原 赳
    • Organizer
      第2回モデル生物丸ごと一匹学会
    • Place of Presentation
      佐用
    • Year and Date
      2012-09-29
    • Related Report
      2012 Final Research Report
  • [Presentation] A comparative study on homologous recombination mediators from T. thermophilus2012

    • Author(s)
      Takeshi Shinohara
    • Organizer
      The 2nd Annual Meeting for Whole-Organism Science Society
    • Place of Presentation
      Sayo
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular Functions of Recombination Mediators in Thermus thermophilus2012

    • Author(s)
      Takeshi Shinohara
    • Organizer
      The 35th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Fukuoka
    • Related Report
      2012 Annual Research Report
  • [Presentation] A Function of an N-terminal Region of Yeast Rad51 Recombinase2012

    • Author(s)
      Naoto Arai
    • Organizer
      The 35th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Fukuoka
    • Related Report
      2012 Annual Research Report
  • [Presentation] RecA組換え酵素のL1ループの制御機能2012

    • Author(s)
      井川粛子
    • Organizer
      第30回染色体ワークショップ
    • Place of Presentation
      Awaji
    • Related Report
      2012 Annual Research Report
  • [Presentation] バクテリアにおけるDNA組換え修復の制御機構2012

    • Author(s)
      井上 仁
    • Organizer
      第30回染色体ワークショップ
    • Place of Presentation
      Awaji
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulation of Thermus Thermophilus RecA function by Recombination mediators2012

    • Author(s)
      篠原 赳
    • Organizer
      第30回染色体ワークショップ
    • Place of Presentation
      Awaji
    • Related Report
      2012 Annual Research Report
  • [Presentation] Reconstitution of homologous recombination in vitro by using Thermus thermophilus RecF pathway proteins2011

    • Author(s)
      井上 仁
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] A novel mechanism for the inhibition of RecA filament extension by RecX2011

    • Author(s)
      奥居 沙弥
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 出芽酵母Rad52-Rad51によるD-loop形成におけるRad52のC端ドメインの必要性2011

    • Author(s)
      新井 直人
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of the functions of recombination mediators in homologous pairing2011

    • Author(s)
      篠原 赳
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 、Local folding of the N-terminal domain of RecA upon protein-protein / protein-DNA interactions and its role2011

    • Author(s)
      美川 務
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 酵素結晶固定化電極を用いたバイオ電池の高出力化2011

    • Author(s)
      重森 康司
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Reconstitution of homologous recombination in vitro by using Thermus thermophilus RecF pathway proteins2011

    • Author(s)
      井上仁
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] A novel mechanism for the inhibition of RecA filament extension by RecX2011

    • Author(s)
      奥居沙弥
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 出芽酵母Rad52-Rad51によるD-loop形成におけるRad52のC端ドメインの必要性2011

    • Author(s)
      新井直人
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of the functions of recombination mediators in homologous pairing2011

    • Author(s)
      篠原赳
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Local folding of the N-terminal domain of RecA upon protein-protein/protein-DNA interactions and its role2011

    • Author(s)
      美川務
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市(招待講演)
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 酵素結晶固定化電極を用いたバイオ電池の高出力化2011

    • Author(s)
      重森康司
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] バクテリアにおけるDNA組換え修復系2011

    • Author(s)
      井上 仁
    • Organizer
      第21回DNA複製・組換え・ゲノム安定性制御ワークショップ
    • Place of Presentation
      福津
    • Year and Date
      2011-10-25
    • Related Report
      2012 Final Research Report
  • [Presentation] バクテリアにおけるDNA組換え修復系2011

    • Author(s)
      井上仁
    • Organizer
      第21回DNA複製・組換え・ゲノム安定性制御ワークショップ
    • Place of Presentation
      福岡県福津市
    • Year and Date
      2011-10-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 天然変性領域としてのRecAのN末端ドメイン:その機能と役割2011

    • Author(s)
      美川 務
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 天然変性領域としてのRecAのN末端ドメイン:その機能と役割2011

    • Author(s)
      美川務
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都府京都市
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高度好熱菌蛋白質を用いた in vitro DNA 相同組換えの再構築2011

    • Author(s)
      井上 仁
    • Organizer
      第1回モデル生物丸ごと一匹学会
    • Place of Presentation
      佐用
    • Year and Date
      2011-08-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 高度好熱菌蛋白質を用いたin vitro DNA相同組換えの再構築2011

    • Author(s)
      井上仁
    • Organizer
      第1回モデル生物丸ごと一匹学会
    • Place of Presentation
      兵庫県佐用郡(招待講演)
    • Year and Date
      2011-08-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] RecAの組換え反応に対するRecXの阻害機構2011

    • Author(s)
      奥居 沙弥
    • Organizer
      第1回モデル生物丸ごと一匹学会
    • Place of Presentation
      佐用
    • Year and Date
      2011-08-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 組換えメディエーターによる D-loop 反応制御2011

    • Author(s)
      篠原 赳
    • Organizer
      第1回モデル生物丸ごと一匹学会
    • Place of Presentation
      佐用
    • Year and Date
      2011-08-19
    • Related Report
      2012 Final Research Report
  • [Presentation] RecAの組換え反応に対するRecXの阻害機構2011

    • Author(s)
      奥居沙弥
    • Organizer
      第1回モデル生物丸ごと一匹学会
    • Place of Presentation
      兵庫県佐用郡
    • Year and Date
      2011-08-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 組換えメディエーターによるD-loop反応制御2011

    • Author(s)
      篠原赳
    • Organizer
      第1回モデル生物丸ごと一匹学会
    • Place of Presentation
      兵庫県佐用郡
    • Year and Date
      2011-08-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 蛋白質間相互作用により生じる単鎖DNA結合蛋白質(SSB/RPA)のssDNAからの解離の一般的機構2011

    • Author(s)
      井上 仁
    • Organizer
      第11回日本蛋白質科学会年会
    • Place of Presentation
      吹田
    • Year and Date
      2011-06-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 蛋白質間相互作用により生じる単鎖DNA結合蛋白質(SSB/RPA)のssDNAからの解離の一般的機構2011

    • Author(s)
      井上仁
    • Organizer
      第11回日本蛋白質科学会年会
    • Place of Presentation
      大阪府吹田市
    • Year and Date
      2011-06-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Displacement mechanism for SSB from single-stranded DNA by a recombination mediator: SSB-RecO interaction at the atomic resolution2011

    • Author(s)
      Jin Inoue
    • Organizer
      International Symposium on the Physicochemical Field for Genetic Activities
    • Place of Presentation
      Awaji
    • Year and Date
      2011-01-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Displacement mechanism for SSB from single-stranded DNA by a recom bination mediator : SSB-RecO interaction at the atomic resolution2011

    • Author(s)
      Jin Inoue
    • Organizer
      International Symposium on the Physicochemical Field for Genetic Activities
    • Place of Presentation
      兵庫県淡路市
    • Year and Date
      2011-01-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 、出芽酵母Rad51によるD-loop形成促進のためのRad52第二DNA結合部位の機能2011

    • Author(s)
      新井 直人
    • Organizer
      第28回染色体ワークショップ
    • Place of Presentation
      加賀
    • Year and Date
      2011-01-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 出芽酵母Rad51によるD-loop形成促進のためのRad52第二DNA結合部位の機能2011

    • Author(s)
      新井直人
    • Organizer
      第28回染色体ワークショップ
    • Place of Presentation
      石川県加賀市
    • Year and Date
      2011-01-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mitochondrial DNA homoplasmy as gene homogenization of repeated sequences by rolling circle replication2010

    • Author(s)
      Takehiko Shibata
    • Organizer
      7th ASMRM and 10th J-mit
    • Place of Presentation
      Fukuoka
    • Year and Date
      2010-12-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Mitochondrial DNA homoplasmy as gene homogenization of repeated sequences by rolling circle replication2010

    • Author(s)
      Takehiko Shibata
    • Organizer
      7th ASMRM and 10th J-mit
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 、ssDNA 上でのSSB の置換におけるSSB-蛋白質相互作用の役割2010

    • Author(s)
      井上 仁
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 (BMB2010)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2012 Final Research Report
  • [Presentation] ssDNA上でのSSBの置換におけるSSB-蛋白質相互作用の役割2010

    • Author(s)
      井上仁
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会(BMB2010)
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] RecA/Rad51ファミリーのフィラメント形成は相同DNA対合反応には必要ない2010

    • Author(s)
      増田 ときは
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 (BMB2010)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 出芽酵母Rad52の第二DNA結合部位も相同組換えに必要である2010

    • Author(s)
      新井 直人
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会 (BMB2010)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] RecA/Rad51ファミリーのフィラメント形成は相同DNA対合反応には必要ない2010

    • Author(s)
      増田ときは
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会(BMB2010)
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 出芽酵母Rad52の第二DNA結合部位も相同組換えに必要である2010

    • Author(s)
      新井直人
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会(BMB2010)
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] A mechanism for SSB displacement from single-stranded DNA upon SSB-protein interaction2010

    • Author(s)
      Jin Inoue
    • Organizer
      The 7^<th> International 3R Symposium,
    • Place of Presentation
      Toyama
    • Year and Date
      2010-10-27
    • Related Report
      2012 Final Research Report
  • [Presentation] A mechanism for SSB displacement from single-stranded DNA upon SSB-protein interaction2010

    • Author(s)
      Jin Inoue
    • Organizer
      The 7^<th> International 3R Symposium
    • Place of Presentation
      富山県富山市
    • Year and Date
      2010-10-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] A mechanism of DNA homology search, based on the structure of DNA bound to proteins that promote homologous recombination2010

    • Author(s)
      Tsutomu Mikawa
    • Organizer
      The 12^<th> IUBMB (OzBio2010)
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2010-09-27
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] A general mechanism for SSB displacement from ssDNA upon SSB-protein interaction2010

    • Author(s)
      井上 仁
    • Organizer
      理研シンポジウム「高度好熱菌丸ごと一匹プロジェクト」第9回連携研究会
    • Place of Presentation
      佐用
    • Year and Date
      2010-08-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 、Direct interaction of RecO with RecA is involved in regulation of RecA function2010

    • Author(s)
      篠原 赳
    • Organizer
      理研シンポジウム「高度好熱菌丸ごと一匹プロジェクト」第9回連携研究会
    • Place of Presentation
      佐用
    • Year and Date
      2010-08-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of the inhibition mechanism of extension of RecA filament by RecX2010

    • Author(s)
      奥居 沙弥
    • Organizer
      理研シンポジウム「高度好熱菌丸ごと一匹プロジェクト」
    • Place of Presentation
      佐用
    • Year and Date
      2010-08-20
    • Related Report
      2012 Final Research Report
  • [Presentation] A general mechanism for SSB displacement from ssDNA upon SSB-protein interaction2010

    • Author(s)
      Jin Inoue
    • Organizer
      理研シンポジウム「高度好熱菌丸ごと一匹プロジェクト」第9回連携研究会
    • Place of Presentation
      兵庫県佐用郡
    • Year and Date
      2010-08-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Direct interaction of RecO with RecA is involved in regulation of RecA function2010

    • Author(s)
      Takeshi Shinohara
    • Organizer
      理研シンポジウム「高度好熱菌丸ごと一匹プロジェクト」第9回連携研究会
    • Place of Presentation
      兵庫県佐用郡
    • Year and Date
      2010-08-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analysis of the inhibition mechanism of extension of RecA filament by RecX2010

    • Author(s)
      Saya Okui
    • Organizer
      理研シンポジウム「高度好熱菌丸ごと一匹プロジェクト」第9回連携研究会
    • Place of Presentation
      兵庫県佐用郡
    • Year and Date
      2010-08-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] The universal DNA structure in homologous recombination2010

    • Author(s)
      Tsutomu Mikawa
    • Organizer
      The 24th Symposium of the Protein Society
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-08-03
    • Related Report
      2012 Final Research Report
  • [Presentation] The universal DNA structure in homologous recombination2010

    • Author(s)
      Tsutomu Mikawa
    • Organizer
      The 24th Symposium of the Protein Society
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2010-08-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 相同組換え開始制御に働く天然変性タンパク質の機能2010

    • Author(s)
      柴田 武彦
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 相同組換え開始制御に働く天然変性タンパク質の機能2010

    • Author(s)
      柴田武彦
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] SSB-C 末端酸性領域とRecO の相互作用によるSSB のssDNA からの解離機構の解明2010

    • Author(s)
      井上 仁
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-17
    • Related Report
      2012 Final Research Report
  • [Presentation] RecA はなぜフィラメントを形成する必要があるのか?-単量体及び二量体の活性をもとに-2010

    • Author(s)
      笠置 原央
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-17
    • Related Report
      2012 Final Research Report
  • [Presentation] SSB-C末端酸性領域とRecOの相互作用によるSSBのssDNAからの解離機構の解明2010

    • Author(s)
      井上仁
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] RecAはなぜフィラメントを形成する必要があるのか?-単量体及び二量体の活性をもとに-2010

    • Author(s)
      笠置原央
    • Organizer
      第10回日本蛋白質科学会年会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] A novel rice SPO11 homologue, SPO11D, induces meiotic chromosme aberration and DNA double-stranded breaks in the fruit-fly2010

    • Author(s)
      Yoshinori Shingu
    • Organizer
      EMBO Conference Series on Recombination & Connections to SUMO and Ubiquitin Modifications
    • Place of Presentation
      Lucca, Italy
    • Year and Date
      2010-05-19
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 酵素結晶固定化電極及び酵素結晶固定化電極の製造方法、並びに酵素結晶固定化電極を備えるバイオ電池及びバイオセンサー2011

    • Inventor(s)
      重森康司、美川 務
    • Industrial Property Rights Holder
      理化学研究所、アイシン精機
    • Filing Date
      2011-08-24
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 高度好熱菌由来の改変型一本鎖DNA結合タンパク質、及び該タンパク質を用いた核酸の等温増幅方法2011

    • Inventor(s)
      美川 務、柴田武彦、重森康司
    • Industrial Property Rights Holder
      理化学研究所、アイシン精機
    • Acquisition Date
      2011-11-11
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 高度好熱菌由来の改変型一本鎖DNA結合タンパク質、及び該タンパク質を用いた核酸の等温増幅方法2011

    • Inventor(s)
      美川 務、柴田武彦、重森康司
    • Industrial Property Rights Holder
      理化学研究所、アイシン精機
    • Acquisition Date
      2011-07-05
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 酵素結晶固定化電極及び酵素結晶固定化電極の製造方法、並びに酵素結晶固定化電極を備えるバイオ電池及びバイオセンサー2011

    • Inventor(s)
      重森康司, 美川務
    • Industrial Property Rights Holder
      (独)理化学研究所アイシン精機(株)
    • Filing Date
      2011-08-24
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 酵素結晶固定化電極及び酵素結晶固定化電極の製造方法、並びに酵素結晶固定化電極を備えるバイオ電池及びバイオセンサー2011

    • Inventor(s)
      重森康司, 美川務
    • Industrial Property Rights Holder
      (独)理化学研究所アイシン精機(株)
    • Filing Date
      2011-08-24
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 酵素結晶固定化電極及び酵素結晶固定化電極の製造方法、並びに酵素結晶固定化電極を備えるバイオ電池及びバイオセンサー2010

    • Inventor(s)
      重森康司、美川 務
    • Industrial Property Rights Holder
      理化学研究所、アイシン精機
    • Industrial Property Number
      2010-189788
    • Filing Date
      2010-08-26
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 酵素結晶固定化電極及び酵素結晶固定化電極の製造方法、並びにこれを備えるバイオ燃料電池及びバイオセンサー2010

    • Inventor(s)
      重森康司美川務
    • Industrial Property Rights Holder
      (独)理化学研究所アイシン精機(株)
    • Industrial Property Number
      2010-189788
    • Filing Date
      2010-08-26
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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