Roles of heparan sulfate glycosaminoglycan containing positive charged domain on cell proliferation, differentiation and apoptosis
Project/Area Number |
22570150
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Functional biochemistry
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Research Institution | Nihon Pharmaceutical University (2011-2012) Aichi Cancer Center Research Institute (2010) |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
EHARA Takashi 松本大学, 人間健康学部, 教授 (00203646)
ODA Koji 愛知県がんセンター(研究所), 疫学・予防部, 研究員 (30311715)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 糖鎖生物学 / ヘパラン硫酸糖鎖 / 陽性荷電 / ヘパラン硫酸 / 細胞増殖 / JM403抗原 / がんマーカー / 上皮 / 細胞分化 / 分化 / アポトーシス / がんバイオマーカー |
Research Abstract |
Expression of heparan sulfate glycosaminoglycan with positively charged domain (JM403 antigen) in cytoplasm was examined in proliferative and/or differentiated cells of cancers and fetal rodent tissues. The JM403 antigen was limitedly expressed in epithelial cells but not in nervous cells and connective tissue cells, suggesting its involvement with epithelial proliferation and differentiation.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Cytoplasmic expression of the JM403 antigen GlcA-GlcNH3+ on heparan sulfate glycosaminoglycan in mammary carcinomas - A novel proliferative biomarker for breast cancers with high malignancy2010
Author(s)
Fujii M, Yusa A, Yokoyama Y, Kokuryo T, Tsunoda N, Oda K, Nagino M, Ishimaru T, Shimoyama Y, Utsunomiya H, Iwata H, Itoh Y, Itoh J, Kannagi R, Kyogashima M
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Journal Title
Glycoconj J
Volume: 27
Issue: 7-9
Pages: 661-672
DOI
Related Report
Peer Reviewed
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