| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
To identify key residues in ciliate eRF1s for stop codon recognition, we introduced mutations at the predicted sites of Dileptus eRF1 and examined the activity by in vivo yeast assay systems. The results indicate that R128 is one of the key residues preserving the ability to recognize all three stop codons, especially UGA in ciliate eRF1s.
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