Characterization ofEcl1familygenesinvolvedinthechronological lifespan in fission yeast.
| Project/Area Number |
22580079
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Nagoya University |
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Principal Investigator |
AIBA Hirofumi 名古屋大学, 創薬科学研究科, 教授 (60211687)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 酵母 / 寿命 / 老化 / 分裂酵母 / 経時寿命 / Ecl1ファミリー / チェックポイント / マイクロアレイ / Ecl1 / 微生物 / ストレス応答 |
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| Research Abstract |
Understanding of lifespan is one of the important theme in current biology. In this study I analyzed the function of Ecl1 family proteins that extend chronological lifespan of fission yeast when overproduced. I also carried out genetical screening to identify novel factors involved in the regulation of chronological lifespan in fission yeast. As a consequence, I have succeeded to reveal mechanisms of Ecl1 functioning and identified novel factors that are involved in the regulation of chronological lifespan in fission yeast. These results should contribute to better understanding of lifespan in higher eukaryote.
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] Chronological lifespan extension by Ecl1 family proteins depends on Prr1 response regulator in fission yeast.2012
Author(s)
Ohtsuka, H., Azuma, K., Kubota, S., Murakami, H.,Giga-Hama, Y.,Tohda,H. and Aiba, H.
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Journal Title
Genes to Cells.
Volume: 17
Pages: 39-52
Related Report
Peer Reviewed
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[Journal Article] Ecl1, a regulator ofthechronologicallifespan of Schizosaccharomyces pombe , is induced upon nitrogen starvation.2011
Author(s)
Miwa, Y., Ohtsuka, H., Naito, C., Murakami, H. and Aiba, H.
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Journal Title
Biosci. Biotech.Biochem.
Volume: 75
Pages: 279-283
Related Report
Peer Reviewed
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[Journal Article] Pma1, a P-type proton ATPase, i s a determinant of chronological lifespan in fission yeast.2010
Author(s)
Ito, H.,Oshiro,T.,Fujita,Y.,Kubota, S., Ohtsuka,H., H.,Naito,C.,Murakami, and Aiba, H.
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Journal Title
J. Biol. Chem.
Volume: 285
Pages: 34616-34620
Related Report
Peer Reviewed
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[Journal Article] Pma1, a P-type proton ATPase, is a determinant of chronological lifespan in fission yeast.2010
Author(s)
Ito, H., Oshiro, T., Fujita, Y., Kubota, S., Naito, C., Ohtsuka, H., Murakami, H., Aiba, H.
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Journal Title
J.Biol.Chem.
Volume: 285
Pages: 34616-34620
Related Report
Peer Reviewed
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[Presentation] Pma1, a P-type proton ATPase, is a determinant of chronological lifespan in fission yeast2011
Author(s)
Hirokazu Ito, Tomoko Oshiro, Yasuyuki Fujita, Sachiko Kubota, Chikako Naito, Hokuto Ohtsuka, Hiroshi Murakami, and Hirofumi Aiba.
Organizer
The 6 th international fission yeast meeting
Place of Presentation
Boston, USA
Related Report
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[Presentation] Pmal, a P-type proton ATPase, is a determinant of chronological lifespan in fission yeast2011
Author(s)
Hirokazu Ito, Tomoko Oshiro, Yasuyuki Fujita, Sachiko Kubota, Chikako Naito, Hokuto Ohtsuka, Hiroshi Murakami, Hirofumi Aiba
Organizer
The 6 th international fission yeast meeting
Place of Presentation
Boston, USA
Related Report
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