Exploration of novel anthelmintics from rare sugars and their ester derivatives
| Project/Area Number |
22580122
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Bioproduction chemistry/Bioorganic chemistry
|
|---|
| Research Institution | Kagawa University |
|---|
Principal Investigator |
SATO Masashi 香川大学, 農学部, 教授 (20263890)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAWANAMI Yasuhiro 香川大学, 農学部, 教授 (30169742)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 希少糖 / 抗線虫薬 / C. elegans / D-アロース / C.elegans |
|---|
| Research Abstract |
Rare sugars and their ester derivatives were examined for anthelmintic activity against the nematode Caenorhabditis elegans. Among the aldohexose stereoisomers, D-allose, the C3 epimer of D-glucose, inhibited the growth of C. elegans. We found that fatty acid estersof D-allose surpassed the sugar itself in anthelmintic activity. 6-O-octanoyl-D-allose showed the strongest toxicity among the fatty acid esters of D-allose.
|
Report
(4 results)
Research Products
(13 results)
