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Studies on the regulatory mechanism of dispensable amino acids metabolism in response to protein requirement

Research Project

Project/Area Number 22580140
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionKyoto University (2012)
Kyoto Prefectural University (2010-2011)

Principal Investigator

KANAMOTO Ryuhei  京都大学, 大学院・農学研究科, 教授 (70147297)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords栄養生化学 / アミノ酸代謝 / タンパク質必要量 / 可欠アミノ酸 / アミノ酸応答経路 / アスパラギン合成酵素 / 3-ホスホグリセリン酸脱水素酵素 / 可決アミノ酸 / 3-ホスホグリセリン酸脱水素酵素
Research Abstract

It is suggested that methionine play a signal for protein nutrition and regulates the expression of enzymes of dispensable amino acids synthesis in response to protein nutrition. To adapt for different protein nutrition, consecutive nutritional signal must be required. In addition, the adaptative response of the expression of enzymes to protein nutrition is different in respective organs, suggesting that requirement of dispensable amino acids differ from organ to organ.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (19 results)

All 2013 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (15 results) Remarks (1 results)

  • [Journal Article] Adverse effects of excessive leucine intake depend on dietary protein intake: a transcriptomic analysis to identify useful biomarkers2013

    • Author(s)
      W. Imamura, R. Yoshimura, M. Takai, J. Yamamura, R. Kanamoto, H. Kato
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: Vol.59 Pages: 45-55

    • NAID

      130003368148

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adverse effects of excessive leucine intake depend on dietary protein intake: a transcriptomic analysis to identify useful biomarkers2013

    • Author(s)
      Wataru Imamura
    • Journal Title

      J. Nutr. Sci. Vitaminology

      Volume: 59 Pages: 45-55

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Vagotomy Alleviates the Anorectic Effect of an Excess Amount of Dietary Leucine on Rats Fed a Low-protein Diet

    • Author(s)
      Ryoji YOSHIMURA, Yee Yin HO, Takafumi MIZUSHIGE, Kousaku OHINATA, and Ryuhei KANAMOTO
    • Journal Title

      Biosci. Biotech. Biochem

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 食餌のメチオニンはラット肝臓におけるアスパラギン合成酵素と 3- ホスホグリセリン酸脱水素酵素の遺伝子発現を制御する2013

    • Author(s)
      生木 裕也 他7名
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2013-05-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 可欠アミノ酸代謝酵素の発現に与えるロイシンの特異的影響2013

    • Author(s)
      吉村亮二
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学 川内北キャンパス
    • Related Report
      2012 Annual Research Report
  • [Presentation] 食餌のメチオニンはラット肝臓におけるアスパラギン合成酵素と 3- ホスホグリセリン酸脱水素酵素の遺伝子発現を制御する2013

    • Author(s)
      生木裕也
    • Organizer
      第67回日本栄養・食糧学会
    • Place of Presentation
      名古屋大学 東山キャンパス
    • Related Report
      2012 Annual Research Report
  • [Presentation] DIETARY METHIONINE REGULATES THE EXPRESSION OF ASPARAGINE SYNTHETASE AND 3-PHOSPHOGLYCERATE DEHYDROGENASE IN RAT LIVER2013

    • Author(s)
      Hiroya Namaki
    • Organizer
      第20回国際栄養学会議
    • Place of Presentation
      スペイン バルセロナ
    • Related Report
      2012 Annual Research Report
  • [Presentation] 低タンパク質栄養時におけるLeu過剰摂取が可欠アミノ酸代謝酵素の発現に与える影響2012

    • Author(s)
      吉村亮二 他3名
    • Organizer
      日本農芸化学会大会
    • Place of Presentation
      京都女子大学
    • Year and Date
      2012-03-24
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 摂食に伴う門脈および頸静脈血中アミノ酸濃度の経時変化ーカテーテル留置法を用いた解析―2012

    • Author(s)
      津崎洋平
    • Organizer
      第66回日本栄養・食糧学会
    • Place of Presentation
      東北大学 川内北キャンパス
    • Related Report
      2012 Annual Research Report
  • [Presentation] 摂食に伴う血中アミノ酸の経時変化-カテーテル留置法を用いた解析-2011

    • Author(s)
      津崎洋平, 他3名
    • Organizer
      日本栄養・食糧学会近畿支部大会
    • Place of Presentation
      近畿大学農学部キャンパス
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 可欠アミノ酸代謝酵素の発現変動とタンパク質栄養への適応2011

    • Author(s)
      中瀬純平, 他5名
    • Organizer
      日本農芸化学会関西・中部支部合同大会
    • Place of Presentation
      京都大学
    • Year and Date
      2011-10-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of the gene expression of dispensable amino acid-metabolic enzymes by ingestion of dietary protein2011

    • Author(s)
      中瀬純平 他2名
    • Organizer
      国際栄養学会議
    • Place of Presentation
      Suntec Singapore International Convention & Exhibition Centre
    • Year and Date
      2011-07-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Regulation of the gene expression of dispensable amino acid-metabolic enzymes by ingestion of dietary protein2011

    • Author(s)
      中瀬純平, 他2名
    • Organizer
      アジア栄養学会議
    • Place of Presentation
      Suntec Singapore International Convention & Exhibition Centre
    • Year and Date
      2011-07-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] タンパク質栄養と可決アミノ酸代謝酵素の発現制御2011

    • Author(s)
      金本龍平
    • Organizer
      タンパク質栄養と可決アミノ酸代謝酵素の発現制御
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-07-08
    • Related Report
      2012 Final Research Report
  • [Presentation] タンパク質栄養と可決アミノ酸代謝酵素の発現制御2011

    • Author(s)
      金本龍平
    • Organizer
      日本外科代謝栄養学会・日本アミノ酸学会合同シンポジウム
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食餌タンパク質摂取に伴う可欠アミノ酸代謝酵素遺伝子の発現制御2011

    • Author(s)
      中瀬純平, 他3名
    • Organizer
      日本栄養・食糧学会大会
    • Place of Presentation
      お茶の水女子大学
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] ロイシン過剰摂取による可欠アミノ酸代謝酵素の発現変動2011

    • Author(s)
      高井まりえ, 他3名
    • Organizer
      日本栄養・食糧学会大会
    • Place of Presentation
      お茶の水女子大学
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 可決アミノ酸代謝酵素の発現制御に関わるタンパク質由来シグナルの性質について2010

    • Author(s)
      菊山智宏, 他3名
    • Organizer
      日本農芸化学会
    • Place of Presentation
      近畿大学農学部
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.sseiri.kais.kyoto-u.ac.jp/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-11-30   Modified: 2019-07-29  

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