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2012 Fiscal Year Final Research Report

Studies on the regulatory mechanism of dispensable amino acids metabolism in response to protein requirement

Research Project

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Project/Area Number 22580140
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionKyoto University (2012)
Kyoto Prefectural University (2010-2011)

Principal Investigator

KANAMOTO Ryuhei  京都大学, 大学院・農学研究科, 教授 (70147297)

Project Period (FY) 2010 – 2012
Keywords栄養生化学 / アミノ酸代謝 / タンパク質必要量 / 可欠アミノ酸 / アミノ酸応答経路
Research Abstract

It is suggested that methionine play a signal for protein nutrition and regulates the expression of enzymes of dispensable amino acids synthesis in response to protein nutrition. To adapt for different protein nutrition, consecutive nutritional signal must be required. In addition, the adaptative response of the expression of enzymes to protein nutrition is different in respective organs, suggesting that requirement of dispensable amino acids differ from organ to organ.

Research Products

(7 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Adverse effects of excessive leucine intake depend on dietary protein intake: a transcriptomic analysis to identify useful biomarkers2013

    • Author(s)
      W. Imamura, R. Yoshimura, M. Takai, J. Yamamura, R. Kanamoto, H. Kato
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: Vol.59 Pages: 45-55

    • Peer Reviewed
  • [Journal Article] The Vagotomy Alleviates the Anorectic Effect of an Excess Amount of Dietary Leucine on Rats Fed a Low-protein Diet

    • Author(s)
      Ryoji YOSHIMURA, Yee Yin HO, Takafumi MIZUSHIGE, Kousaku OHINATA, and Ryuhei KANAMOTO
    • Journal Title

      Biosci. Biotech. Biochem

    • Peer Reviewed
  • [Presentation] 食餌のメチオニンはラット肝臓におけるアスパラギン合成酵素と 3- ホスホグリセリン酸脱水素酵素の遺伝子発現を制御する2013

    • Author(s)
      生木 裕也 他7名
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2013-05-25
  • [Presentation] 低タンパク質栄養時におけるLeu過剰摂取が可欠アミノ酸代謝酵素の発現に与える影響2012

    • Author(s)
      吉村亮二 他3名
    • Organizer
      日本農芸化学会大会
    • Place of Presentation
      京都女子大学
    • Year and Date
      2012-03-24
  • [Presentation] Regulation of the gene expression of dispensable amino acid-metabolic enzymes by ingestion of dietary protein2011

    • Author(s)
      中瀬純平 他2名
    • Organizer
      国際栄養学会議
    • Place of Presentation
      Suntec Singapore International Convention & Exhibition Centre
    • Year and Date
      2011-07-14
  • [Presentation] タンパク質栄養と可決アミノ酸代謝酵素の発現制御2011

    • Author(s)
      金本龍平
    • Organizer
      タンパク質栄養と可決アミノ酸代謝酵素の発現制御
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-07-08
  • [Remarks]

    • URL

      http://www.sseiri.kais.kyoto-u.ac.jp/

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Published: 2014-08-29  

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