DEVELOPMENT OF NOVEL NITROGEN-CONTAINING 1,3-DIPOLARS
| Project/Area Number |
22590017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Showa Pharmaceutical University |
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Principal Investigator |
TAMURA Osamu 昭和薬科大学, 薬学部, 教授 (30257141)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ヘテロ環化学 / ニトロン / 付加環化反応 / HPA-12 / N-アシルニトロン / 分子内反応 / 薬学 / 有機化学 / 1,3-双極子 / 環化付加反応 / アミドN-ボラノニトロン / 3,5-cis-イソキサゾリジン / tubulysin誘導体 / dysiherbain / 還化付加反応 / 3,5-cis-イソキサゾリジ / tubulysin / negamycin |
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| Research Abstract |
A cytosolic protein, CERT, is known to mediate the transport of ceramide from the endoplasmic reticulum to the Golgi apparatus. Synthesis of syn-HPA-12, the selective inhibitor of CERT, was accomplished by using cis-selective cycloaddition reaction of C-a
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Total Synthesis of Tubulysins2010
Author(s)
Taku Shibue, Toshihiro Hirai, Iwao Okamoto, Nobuyoshi Morita, Hyuma Masu, Isao Azumaya, Osamu Tamura
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Journal Title
Chemistry - A European Journal
Volume: 16
Issue: 38
Pages: 11678-11688
DOI
NAID
Related Report
Peer Reviewed
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