| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Activity-regulated cytoskeleton-associated protein （Arc) is a regulator of neuronal function. In this study, we have found that SRF cofactors, megakaryoblastic leukemia 1（MKL1) and Ets-like transcription factor 1 （Elk1), activate and inhibit Arc gene transcription, respectively. These findings, at least in part, contribute to a better understanding of brain function and provide a novel insight into SRF cofactor-based drug design.
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