Linkage of neuronal morphology to gene expression:actin-bound transcription cofactor MKL and its regulation by BDNF
Project/Area Number |
22590080
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | University of Toyama |
Principal Investigator |
TABUCHI Akiko 富山大学, 大学院・医学薬学研究部(薬学), 准教授 (40303234)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 遺伝子発現 / 転写因子 / 脳由来神経栄養因子(BDNF) / SRF / Arc / MKL / TCF / シナプス / 神経形態 / 神経生物学 / 分子生物学 |
Research Abstract |
Activity-regulated cytoskeleton-associated protein (Arc) is a regulator of neuronal function. In this study, we have found that SRF cofactors, megakaryoblastic leukemia 1(MKL1) and Ets-like transcription factor 1 (Elk1), activate and inhibit Arc gene transcription, respectively. These findings, at least in part, contribute to a better understanding of brain function and provide a novel insight into SRF cofactor-based drug design.
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Report
(4 results)
Research Products
(68 results)
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[Journal Article] Synthesis and biological evaluation of pyrethroid insecticide-derivatives as a chemical inducer for Bdnf mRNA expression in neurons2012
Author(s)
Matsuya, Y., Ihara, D.,Fukuchi, M., Honma, D., Itoh, K., Tabuchi, A., Nemoto, H. and Tsuda, M
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Journal Title
Bioorg. Med. Chem
Volume: 20
Pages: 2564-2371
Related Report
Peer Reviewed
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[Journal Article] Deltamethrin, a type II pyrethroid insecticide, nas neurotrophic effects on neurons with continuous activation of the Bdnf promoter2012
Author(s)
Ihara, D., Fukuchi, M., Honma, D., Takasaki, I., Ishikawa, M., Tabuchi, A. and Tsuda, M
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Journal Title
Neuropharmacology
Volume: 62
Pages: 1091-1098
Related Report
Peer Reviewed
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[Journal Article] Up-regulation of L-type amino acid transporter 1 (LAT1) in cultured rat retinal capillary endothelial cells in response to glucose deprivation. Drug2012
Author(s)
Matsuyama, R., Tomi, M., Akanuma, S., Tabuchi, A., Kubo, Y., Tachikawa, M. and Tsuda M
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Journal Title
Metab. Pharmacokinet
Volume: 27
Pages: 317-324
Related Report
Peer Reviewed
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[Journal Article] Up-regulation of <small>L</small>-Type Amino Acid Transporter 1 (LAT1) in Cultured Rat Retinal Capillary Endothelial Cells in Response to Glucose Deprivation2012
Author(s)
Matsuyama, R., Tomi, M., Akanuma, SI, Tabuchi, A., Kubo, Y., Tachikawa, M., Hosoya KI.
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Journal Title
Drug Metabolism and Pharmacokinetics
Volume: 27
Issue: 3
Pages: 317-324
DOI
NAID
ISSN
1347-4367, 1880-0920
Related Report
Peer Reviewed
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[Journal Article] Synthesis and biological evaluation of pyrethroid insecticide-derivatines as a chenical inducer for Bdnf mRNA expression in neurons2012
Author(s)
Matsuya, Y., Ihara, D., Fukuchi, M., Honma, D., Itoh, K., Tabuchi, A., Nemoto, H., Tsuda, M.
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Journal Title
Bioorg.Med.Chem.
Volume: 20
Issue: 8
Pages: 2564-2571
DOI
Related Report
Peer Reviewed
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[Journal Article] Deltamethrin, a type II pyrethroid insecticide, has neurotrophic effects on neurons with continuous activation of the Bdnf promoter2011
Author(s)
Ihara, D., Fukuchi, M., Honma, D., Takasaki, I., Ishikawa, M., Tabuchi, A.Tsuda, M.
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Journal Title
Neuropharmacol
Volume: 62
Issue: 2
Pages: 1091-1098
DOI
Related Report
Peer Reviewed
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[Journal Article] Activation of tyrosine hydroxylase (TH) gene transcription induced by brain-derived neurotrophic factor (BDNF) and its selective inhibition through Ca(2+) signals via the N-methyl-D-aspartate (NMDA) receptor2010
Author(s)
Fukuchi, M., Fujii, H., Takachi, H., Ichinose, H., Kuwana, Y., Tabuchi, A. and Tsuda M
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Journal Title
Brain Res
Volume: 1366
Pages: 18-26
Related Report
Peer Reviewed
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[Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) is an upstream regulator of prodynorphin mRNA expression in neurons2010
Author(s)
Dong, Y. X., Fukuchi, M., Inoue, M., Takasaki, I., Tabuchi, A., Wu, C. F. and Tsuda M
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Journal Title
Neurosci, Lett
Volume: 484
Pages: 174-177
Related Report
Peer Reviewed
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[Journal Article] Involvement of the serum response factor coactivator megakaryoblastic leukemia (MKL) in the activin-regulated dendritic complexity of rat cortical neurons2010
Author(s)
Ishikawa, M., Nishijima, N., Shiota, J., Sakagami, H., Tsuchida, K., Mizukoshi, M., Fukuchi, M., Tsuda, M. and Tabuchi, A
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Journal Title
J. Biol. Chem
Volume: 285
Pages: 32734-32743
Related Report
Peer Reviewed
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[Journal Article] Involvement of the serum response factor coactivator megakaryoblastic 1 eukemia (MKL) in the activin-regulated dendritic complexity of rat cortical neurons.2010
Author(s)
Ishikawa, M., Nishijima, N., Shiota, J., Sakagami, H., Tsuchida, K., Mizukoshi, M., Fukuchi, M., Tsuda, M., Tabuchi, A.
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Journal Title
J. Biol. Chem.
Volume: 285
Pages: 32734-32743
Related Report
Peer Reviewed
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[Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) is an upstre am regulator of prodynorphin mRNA expression in neurons.2010
Author(s)
Dong, Y.X., Fukuchi, M., Inoue, M., Takasaki, I., Tabuchi, A., Wu, C. F., Tsuda, M.
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Journal Title
Neurosci. Lett.
Volume: 484
Pages: 174-147
Related Report
Peer Reviewed
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[Journal Article] Activation of tyrosine hydroxylase (TH) gene transcription induced by brain-derived neurotrophic factor (BDNF) and its selective inhibition through Ca (2+) signals evoked via the N-methyl-D-aspartate (NMDA) receptor2010
Author(s)
Fukuchi, M., Fujii, H., Takachi, H., Ichinose, H., Kuwana, Y., Tabuchi, A., Tsuda, M.
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Journal Title
Brain Res.
Volume: 1366
Pages: 18-26
Related Report
Peer Reviewed
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[Presentation] G-protein-coupled receptor (GPCR) signaling induces activity-dependent gene expression through the modulation of N-methyl-D-aspartate receptor (NMDA-R) in neurons.2010
Author(s)
Tsuda, M., Fukuchi, M., Watanabe, S., Kuwana, Y., Takasaki, I., Tabuchi, A.
Organizer
The 40^<th> annual Meeting of the Society for Neuroscience
Place of Presentation
San Diego, USA
Year and Date
2010-11-17
Related Report
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[Presentation] MKL, an actin-binding coactivator for SRF, is involved in TGF-beta family-induced alteration of dendritic morphology and transcriptional activity in rat cortical neurons.2010
Author(s)
Ishikawa, M., Nishijima, N., Shiota, J., Sakagami, H., Tsuchida, K., Tsuda, M., Tabuchi, A.
Organizer
The 40^<th> annual Meeting of the Society for Neuro science
Place of Presentation
San Diego, USA
Year and Date
2010-11-16
Related Report
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[Presentation] Isolation and characterization of rat SRF coactivator MKL1 splice variants differentially expressed in the developing brain.2010
Author(s)
Tabuchi, A., Hakamata, T., Ishikawa, M., Shiota, J., Shoji, S., Fukuchi, M., Tsuda, M.
Organizer
The 40^<th> annual Meeting of the Society for Neuro science
Place of Presentation
San Diego, USA
Year and Date
2010-11-16
Related Report
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