Investigation of the basic mechanisms for damage of central nervous system induced by virus infection
| Project/Area Number |
22590082
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Shujitsu University (2012)
Ehime University (2010-2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARAKI Hiroaki 愛媛大学, 医学部附属病院, 教授 (50294450)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 擬似的ウィルス感染 / polyI:C / 中枢神経障害 / 痙攣 / 角膜キンドリング / てんかん / 擬似的ウイルス感染 / polyI : C / poly I:C / 統合失調症 / ニコチン受容体 |
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| Research Abstract |
Synthetic double-stranded RNA polyI:C elicits viral-like immune responses inmammals. In this study, we found that polyI:C treatment produced marked decrease ofseizure threshold in corneally kindled mice. This exacerbation was suppressed bypretreatment with minocycline, an inhibitor of activated microglia. These resultssuggest that polyI:C treatment in corneal kindled mouse model is a useful tool in thestudy of brain damage including viral infection-related convulsion.
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Report
(4 results)
Research Products
(12 results)
