Investigation of the basic mechanisms for damage of central nervous system induced by virus infection

• Project/Area Number: 22590082
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Shujitsu University (2012); Ehime University (2010-2011)
• Principal Investigator: SUEMARU Katsuya 就実大学, 薬学部, 教授 (50363239)
• Co-Investigator(Kenkyū-buntansha): ARAKI Hiroaki 愛媛大学, 医学部附属病院, 教授 (50294450)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 擬似的ウィルス感染 / polyI:C / 中枢神経障害 / 痙攣 / 角膜キンドリング / てんかん / 擬似的ウイルス感染 / polyI : C / poly I:C / 統合失調症 / ニコチン受容体

Research Abstract

Synthetic double-stranded RNA polyI:C elicits viral-like immune responses inmammals. In this study, we found that polyI:C treatment produced marked decrease ofseizure threshold in corneally kindled mice. This exacerbation was suppressed bypretreatment with minocycline, an inhibitor of activated microglia. These resultssuggest that polyI:C treatment in corneal kindled mouse model is a useful tool in thestudy of brain damage including viral infection-related convulsion.

Research Products

• [Journal Article] Involvement of -4.2 nicotinic acetylcholine receptors in working memory impairment induced by repeated electroconvulsive seizures in rats. (2013)
  • Author(s): Hidaka N, Suemaru K, Kato Y, Araki H.
  • Journal Title: Epilepsy Research Volume: 104 Pages: 181-185
  • Peer Reviewed
• [Journal Article] Involvement of α4β2 nicotinic acetylcholine receptors in working memory impairment induced by repeated electroconvulsive seizures in rats. (2013)
  • Author(s): Hidaka N, Suemaru K, Kato Y, Araki H.
  • Journal Title: Epilepsy Research Volume: 104 Issue: 1-2 Pages: 181-185
  • DOI: 10.1016/j.eplepsyres.2012.09.017
  • Peer Reviewed
• [Journal Article] Effect of heat exposure on aminophylline-induced convulsions in mice. (2011)
  • Author(s): Ochi R, Suemaru K, Watanabe S,Yamaguchi T, Takechi K, Kawasaki H,Araki H.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 34 Pages: 666-670
  • NAID: 130000657777
  • Peer Reviewed
• [Journal Article] Effect of heat exposure on aminophylline-induced convulsions in mice (2011)
  • Author(s): Ochi R, Suemaru K, Watanabe S, Yamaguchi T, Takechi K, Kawasaki H, Araki H
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 34 Pages: 666-670
  • NAID: 130000657777
  • Peer Reviewed
• [Journal Article] Ameliorating effects of tropisetron on dopaminergic disruption of prepulse inhibition via the alpha(7) nicotinic acetylcholine receptor in Wistar rats. (2010)
  • Author(s): Kohnomi S, Suemaru K, Goda M, Choshi T,Hibino S, Kawasaki H, Araki H.
  • Journal Title: BrainResearch Volume: 1353 Pages: 152-158
  • NAID: 120005970398
  • Peer Reviewed
• [Journal Article] Ameliorating effects of tropisetron on dopaminergic disruption of prepulse inhibition via the alpha(7) nicotinic acetylcholine receptor in Wistarrats. (2010)
  • Author(s): Kohnomi S, Suemaru K, Goda M, Choshi T, Hibino S, Kawasaki H, Araki H.
  • Journal Title: Brain Research Volume: 1353 Pages: 152-158
  • NAID: 120005970398
  • Peer Reviewed
• [Presentation] 角膜キンドリングマウスにおける行動変化と抗てんかん薬レベチラセタムの影響. (2013)
  • Author(s): 越智理香,末丸克矢,武智研志,田坂祐一,田中守,田中亮裕,荒木博陽.
  • Organizer: 第86回日本薬理学会年会.
  • Place of Presentation: 福岡
• [Presentation] 角膜キンドリングマウスにおける行動変化と抗てんかん薬レベチラセタムの影響 (2013)
  • Author(s): 越智理香，末丸克矢，武智 研志，田坂祐一，田中守，田中亮裕，荒木博陽
  • Organizer: 第86回日本薬理学会年会
  • Place of Presentation: 福岡国際会議場
• [Presentation] 角膜キンドリングを用いた抗痙攣および痙攣増悪作用の評価方法に関する基礎的検討. (2012)
  • Author(s): 越智理香,末丸克矢,武智研志,田坂祐一,田中亮裕,田中守,荒木博陽.
  • Organizer: 第22回日本臨床精神神経薬理学会・第42回日本神経精神薬理学会・合同年会.
  • Place of Presentation: 栃木
• [Presentation] 角膜キンドリングを用いた抗痙攣および痙攣増悪作用の評価方法に関する基礎的検討 (2012)
  • Author(s): 越智理香，末丸克矢，武智研志，田坂祐一，田中亮裕，田中守，荒木博陽
  • Organizer: 第22回日本臨床精神神経薬理学会・第42回日本神経精神薬理学会・合同年会
  • Place of Presentation: 栃木県総合文化センター
• [Presentation] PolyI:C投与による疑似的ウイルス感染マウスにおけるペンチレンテトラゾール誘発けいれん. (2011)
  • Author(s): 越智理香,武智研志,末丸克矢,荒木博陽.
  • Organizer: 第21回日本臨床精神神経薬理学会・第41回日本神経精神薬理学会・合同年会.
  • Place of Presentation: 東京
  • Year and Date: 2011-10-27
• [Presentation] Poly I:C投与による疑似的ウイルス感染マウスにおけるペンチレンテトラゾール誘発けいれん (2011)
  • Author(s): 越智理香, 武智研志, 末丸克矢, 荒木博陽
  • Organizer: 第21回日本臨床精神神経薬理学会第41回日本神経精神薬理学会合同年会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-27