Molecular mechanism of neuroprotection by molecular

• Project/Area Number: 22590084
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Kyushu University
• Principal Investigator: NODA Mami 九州大学, 薬学研究院, 准教授 (80127985)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 酸化ストレス / 神経保護 / パーキンソン病 / 神経生物学 / 水素分子 / 神経疾患 / 抗酸化作用 / 消化管ホルモン / グレリン / 予防医学 / 視神経障害 / 虚血

Research Abstract

We showed that low concentration of molecular hydrogen (0.008 ppm) in drinkingwater had neuroprotective effects in Parkinson’s Disease model mice (Fujita et al., 2009). However, not only acute anti-oxidative effect but also upregulation of chaperone, heat shock protein (Hsp) 72, and involvement of gastric hormone, ghrelin, was suggested. These results will contribute to a preventive medicine which may be inducedby drinking hydrogen water.

Research Products

• [Journal Article] Exploring the Multifactorial Nature of Autism Through Computational Systems Biology: Calcium and the Rho GTPase RAC1 Under the Spotlight (2013)
  • Author(s): Zeidan-Chulia F, Rybarczyk-Filho JL, Salmina AB, de Oliveira BH, Noda M, Moreira JC
  • Journal Title: Neuromolecular Med Volume: March 02 Issue: 2 Pages: 364-383
  • DOI: 10.1007/s12017-013-8224-3
  • Peer Reviewed
• [Journal Article] Expression. Subunit Composition. and Function of AMPA-Type Glutamate Receptors are Changed in Activated Microglia : Possible Contribution of GluA2 (GluR-B)-Deficiency Under Pathological Conditions (2013)
  • Author(s): Beppu K, et al.
  • Journal Title: GLIA Volume: 61(6) Issue: 6 Pages: 881-891
  • DOI: 10.1002/glia.22481
  • Peer Reviewed
• [Journal Article] A kavalactone derivative inhibits lipopolysaccharide-stimulated iNOS induction and NO production through activation of Nrf2 signaling in BV2 microglial cells (2013)
  • Author(s): Terazawa R, Akimoto N, Kat o T, I t o h T, Fujita Y, Hamada N, Deguchi T, Iinuma M, Noda M, Nozawa Y, Ito M
  • Journal Title: Pharmacol Res Volume: 71 Pages: 34-43
  • DOI: 10.1016/j.phrs.2013.02.002
  • Peer Reviewed
• [Journal Article] Immunohistochemistry of CD38 in Different Cell Types in the Hypothalamus and Pituitary of Male Mice (2013)
  • Author(s): Akimoto N, Kamiyama Y, Yamafuji M, Fujita K, Seike T, Kido MA, Yokoyama S, Higashida H, and Noda M
  • Journal Title: Messenger Volume: 2 Issue: 1 Pages: 1-8
  • DOI: 10.1166/msr.2013.1021
  • Peer Reviewed
• [Journal Article] Immunohistochemistry of CD38 in Different Cell Types in the Hypothalamus and Pituitary of Male Mice (2013)
  • Author(s): Akimoto N, Kamiyama Y, Yamafuji M, Fujita K, Seike T, Kido MA, Yokoyama S, Higashida H, and Noda M.
  • Journal Title: Messenger Volume: 2
  • Peer Reviewed
• [Journal Article] IL-6 Receptor Is a Possible Target against Growth ofMetastasized Lung Tumor Cells in the Brain (2012)
  • Author(s): Noda M, Yamakawa Y, Matsunaga N, Naoe S, Jodoi T, Yamafuji M, AkimotoNoda M, Yamakawa Y, Matsunaga N, Naoe S, Jodoi T, Yamafuji M, Akimoto
  • Journal Title: Int J Mol Sci Volume: 14(1) Issue: 1 Pages: 515-26
  • DOI: 10.3390/ijms14010515
  • Peer Reviewed
• [Journal Article] Anti-inflammatory/anti-amyloidogeniceffects of plasmalogens in lipopolysaccharide-inducedneuroinflammation in adult mice (2012)
  • Author(s): Ifuku M, Katafuchi T, Mawatari S, Noda M, Miake K, Sugiyama M and FujinoT
  • Journal Title: Jneuroinflammation Volume: 9 Pages: 197-197
  • Peer Reviewed
• [Journal Article] Effects of plasmalogen on systemic lipopolysaccharide-induced glial activation and -amyloid accumulation in adult mice (2012)
  • Author(s): Katafuchi T, Ifuku M, Mawatari S, Noda M, Miake K, Sugiyama M, Fujino T
  • Journal Title: Ann. N.Y. Acad. Sci Volume: 1262 Issue: 1 Pages: 85-92
  • DOI: 10.1111/j.1749-6632.2012.06641.x
  • Peer Reviewed
• [Journal Article] Therapeutic approach to neurodegenerative diseases by medical gases: focusing on redox signaling and related antioxidant enzymes. (2012)
  • Author(s): Fujita K, Yamafuji M, Nakabeppu Y, Noda M.
  • Journal Title: Oxid Med Cell Longev Volume: 2012 Pages: 324256-324256
  • DOI: 10.1155/2012/324256
  • Peer Reviewed
• [Journal Article] Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice. (2012)
  • Author(s): Ifuku M, Katafuchi T, Mawatari S, Noda M, Miake K, Sugiyama M and Fujino T.
  • Journal Title: J Neuroinflammation Volume: 9 Issue: 1 Pages: 197-210
  • DOI: 10.1186/1742-2094-9-197
  • Peer Reviewed
• [Journal Article] Inter-regional contribution of enhanced activity of the primary somatosensory cortex to the anterior cingulate cortex accelerates chronic pain behavior (2011)
  • Author(s): Eto K, Wake H, Watanabe M, Ishibashi H, Noda M, Yanagawa Y, Nabekura J
  • Journal Title: J Neurosci Volume: 31 Issue: 21 Pages: 7631-7636
  • DOI: 10.1523/jneurosci.0946-11.2011
  • Peer Reviewed
• [Journal Article] Functional importance of inositol-1,4,5-triphosphate-induced intracellular Ca 2+ mobilization in galanin-induced microglial migration (2011)
  • Author(s): Ifuku M, Okuno Y, Yamakawa Y, Izum K, Seifert S, Kettenmann H, Noda M
  • Journal Title: J Neurochem Volume: 117(1) Issue: 1 Pages: 61-70
  • DOI: 10.1111/j.1471-4159.2011.07176.x
  • Peer Reviewed
• [Journal Article] Role of Immune Cells in Brain Metastasis of Lung Cancer Cells and Neuron-Tumor Cell Interaction. Neurosci Behav Physiol (2011)
  • Author(s): Noda M, Seike T, Fujita K, YamakawaY, Kido M, Iguchi H
  • Journal Title: Mar Volume: 41(3) Pages: 243-251
  • Peer Reviewed
• [Journal Article] Translocator Protein (18kDa) (TSPO)/Peripheral (2011)
  • Author(s): Choi J, Ifuku M, Noda M, Guilarte TR
  • Journal Title: GLIA Volume: 59(2) Pages: 219-30
  • Peer Reviewed
• [Journal Article] Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis (2011)
  • Author(s): Seike T, Fujita K, Yamakawa Y, Kido MA, Takiguchi S, Teramoto N, Iguchi H, Noda M
  • Journal Title: Clin Exp Metastasis Volume: 28(1) Issue: 1 Pages: 13-25
  • DOI: 10.1007/s10585-010-9354-8
  • Peer Reviewed
• [Journal Article] Therapeutic effects of hydrogen in animal models of Parkinson's disease (2011)
  • Author(s): Fujita, et al
  • Journal Title: Parkinson's disease Volume: 176 Pages: 307875-307875
  • DOI: 10.4061/2011/307875
  • Peer Reviewed
• [Journal Article] The principle and the potential approach to ROS-dependent cytotoxicity by non-pharmaceutical therapies : optimal use of medical gases with antioxidant properties (2011)
  • Author(s): Noda, et al
  • Journal Title: Current Pharmaceutical Design Volume: 22 Issue: 22 Pages: 2253-2263
  • DOI: 10.2174/138161211797052600
  • Peer Reviewed
• [Journal Article] Physiology of microglia (2011)
  • Author(s): Kettenmann, et al
  • Journal Title: Physiol Rev. Volume: 91 Pages: 461-553
  • Peer Reviewed
• [Journal Article] Inter-regional Contribution of Enhanced Activity of the Primary Somatosensory Cortex to the Anterior Cingulate Cortex Accelerates Chronic Pain Behavior (2011)
  • Author(s): Eto, et al
  • Journal Title: J.Neurosci. Volume: 31 Pages: 7631-7636
  • Peer Reviewed
• [Journal Article] Neuropeptides as Attractants of Immune Cells in the Brain and their Distinct Signaling (2011)
  • Author(s): Noda, et al
  • Journal Title: Advances in Neuroimmune Biology Volume: 1 Pages: 53-62
  • Peer Reviewed
• [Journal Article] Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis. (2011)
  • Author(s): Seike T., et al.
  • Journal Title: Clinical Experimental Metastasis Volume: 28(1) Pages: 13-25
  • Peer Reviewed
• [Journal Article] Translocator Protein (18kDa) (TSPO)/Peripheral Benzodiazepine Receptor (PBR) specific ligands induce microglia functions consistent with an activated state. (2011)
  • Author(s): Choi J., et al.
  • Journal Title: GLIA Volume: 59(2) Pages: 219-230
  • Peer Reviewed
• [Journal Article] Functional importance of inositol-1,4,5-triphosphate-induced intracellular Ca^<2+> mobilization in galanin-induced microglial migration. (2011)
  • Author(s): Ifuku M., et al.
  • Journal Title: J Neurochemistry Volume: 117(1) Pages: 61-70
  • Peer Reviewed
• [Journal Article] Two genetic variants of CD38 in subjects with autism spectrum disorder and controls. (2010)
  • Author(s): Munesue T., et al.
  • Journal Title: Neuroscience Research Volume: 67(2) Pages: 181-191
  • Peer Reviewed
• [Presentation] ATPによるミクログリア遊走性亢進とオレキシンによる制御 (2012)
  • Author(s): 野田百美、奥野祐子, 直江智子、毛利優希、井福正隆, 片渕俊彦
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 松本
  • Year and Date: 2012-03-30
• [Presentation] Distinct signaling of GPCRs in microglial migration (2012)
  • Author(s): Mami Noda, Yuki Mori, Satoko Naoe, Nozomi Akimoto, Masataka Ifuku
  • Organizer: The 10^<th> Japan-Korea Joint Symposium on Brain, Cardiac and Smooth Muscles
  • Place of Presentation: Gyeongju, Korea(招待講演)
  • Year and Date: 2012-02-18
• [Presentation] 視神経の虚血・再灌流モデルおよびパーキンソン病モデルにおける事前の水素水飲用の効果 (2012)
  • Author(s): 野田百美、藤田慶大、山藤芽実、城戸瑞穂、中別府雄作
  • Organizer: 第2回分子状水素医学シンポジウム
  • Place of Presentation: 北里大学・東京
  • Year and Date: 2012-02-11
• [Presentation] Expression and function of GPCRs in microglia (2012)
  • Author(s): Mami Noda, Yuki Mori, Satoko Naoe, Nozomi Akimoto, Masataka Ifuku
  • Organizer: International Workshop in UOEH 2012 ; "Physiopathplogy of calcium signaling"
  • Place of Presentation: Kitakyushu, Japan(招待講演)
  • Year and Date: 2012-01-20
• [Presentation] Medical Gasを用いたオキシダントダメージの修復 (2012)
  • Author(s): 野田百美
  • Organizer: 千葉大ワークショップ「Slow-aging工学の展開」
  • Place of Presentation: 千葉大学フロンティアメディカルセンター(招待講演)
  • Year and Date: 2012-01-06
• [Presentation] Mechanism of protective effects of molecular hydrogen against oxidative damage. (2012)
  • Author(s): Mami Noda
  • Organizer: Symposium “Physical Aspect of Medical Science”
  • Place of Presentation: Kaohsiung, Taiwan
  • Invited
• [Presentation] Modulation of purinergic signaling and migration in microglia. (2012)
  • Author(s): Mami Noda
  • Organizer: Purine2012
  • Place of Presentation: Fukuoka, Japan.
• [Presentation] Hydrogen-induced resistance against oxidative stress in Parkinson’s disease model mice. (2012)
  • Author(s): Mami Noda, Kyota Fujita, Megumi Yamafuji, Mizuho A. Kido, Yoshinori Tanaka, Yusaku Nakabeppu.
  • Organizer: 8th FENS Forum of European Neuroscience
  • Place of Presentation: Barcelona, Spain
• [Presentation] Effect of thyroid hormone on microglial migration and phagocytosis. (2012)
  • Author(s): Yuki Mori, Nozomi Akimoto, Masataka Ifuku, Mami Noda.
  • Organizer: 8th FENS Forum of European Neuroscience
  • Place of Presentation: Barcelona, Spain
• [Presentation] Interaction between glial cells and metastatic lung cancer cells in the brain. (2012)
  • Author(s): Satoko Naoe, Megumi Yamafuji, Kyota Fujita, Yuki Mori, Nozomi Akimoto, Haruo Iguchi, Mami Noda
  • Organizer: The 11th Biennial Meeting of the Asian-Pacific Society for Neurochemistry/55th Annual Meeting of the Japanese Society for Neurochemisty
  • Place of Presentation: Kobe, Japan
• [Presentation] Role of glial cells in oxidative stress resistance in neurodegenerative diseases (2012)
  • Author(s): Mami Noda, Kyota Fujita, Megumi Yamafuji, Mizuho A. Kido, Yoshinori Tanaka, Yusaku Nakabeppu
  • Organizer: MNS 2012: 4th CONFERENCE OF THE MEDITERRANEAN NEUROSCIENCE SOCIETY
  • Place of Presentation: Istanbul, Turkey
  • Invited
• [Presentation] Molecular hydrogen protects against central nervous system white matter ischemic injury. (2012)
  • Author(s): Mami Noda, Kyota Fujita, Margaret A. Hamner, Megumi Yamafuji, Nozomi Akimoto, Mizuho A. Kido, Yoshinori Tanaka, Yusaku Nakabeppu, Bruce R. Ransom
  • Organizer: Society for Neuroscience, 42nd Annual Meeting
  • Place of Presentation: New Orleans, USA
• [Presentation] Protective effects of molecular hydrogen against ischemic injury (2012)
  • Author(s): Mami Noda, Kyota Fujita, Margaret A. Hamner, Megumi Yamafuji, Nozomi Akimoto, Yusaku Nakabeppu, Bruce R. Ransom
  • Organizer: Trans-Pacific Workshop on Stroke 2012
  • Place of Presentation: New Orleans, USA
  • Invited
• [Presentation] The functional role of neuropeptides and their signaling cascades in microglial migration (2011)
  • Author(s): Mami Noda
  • Organizer: The Israel Society for Neuroscience 20^<th> Annual meeting : Israel-Japan Joint Sympoium
  • Place of Presentation: Eilat, Israel(招待講演)
  • Year and Date: 2011-12-12
• [Presentation] Hydrogen confers resistance to neuronal loss on dopaminergic neurons in mice model of Parkinson's disease (2011)
  • Author(s): Kyota Fujita, Fumiko Inoue, Megumi Yamafuji, Kaoru Beppu, Mizuho A.Kido, Yoshinori Tanaka, Yusaku Nakabeppu, Mami Noda
  • Organizer: Society for Neuroscience, 41st Annual Meeting
  • Place of Presentation: Washington DC.USA.
  • Year and Date: 2011-11-12
• [Presentation] ミクログリアにおけるATPの作用に対する抑制効果とそのメカニズム (2011)
  • Author(s): 野田百美, 奥野祐子, 井福正隆, 直江智子
  • Organizer: 生理学研究会
  • Place of Presentation: 生理学研究所・岡崎
  • Year and Date: 2011-10-21
• [Presentation] ミクログリアの機能に及ぼす甲状腺ホルモンの作用解明 (2011)
  • Author(s): 毛利優希、奥野祐子、藤田慶大、別府薫、秋元望、井福正隆、野田百美
  • Organizer: 西日本生理学会
  • Place of Presentation: 佐賀大学医学部
  • Year and Date: 2011-10-14
• [Presentation] Bradykinin-, but not ATP- and galanin-induced microglial migration, depends on calcium influx through NCX (2011)
  • Author(s): Noda M, Ifuku M
  • Organizer: The 6th International Conference on Sodium Calcium Exchange
  • Place of Presentation: Ischia, Italy(招待講演)
  • Year and Date: 2011-10-04
• [Presentation] パーキンソン病モデルマウスに対する水素含有飲用水の神経保護作用 (2011)
  • Author(s): 藤田慶大、田中喜典、城戸瑞穂、片渕俊彦、中別府雄作、野田百美
  • Organizer: 第54回日本神経化学会
  • Place of Presentation: 山代温泉・石川県
  • Year and Date: 2011-09-26
• [Presentation] Microglia-derived IL-1beta is involved in central mechanisms of fatigue (2011)
  • Author(s): Ifuku M, Izumi K, Otubo S, Noda M, Katafuchi T
  • Organizer: EuroGlia2011 (10^<th> European meeting on Glial cells in Health and Disease)
  • Place of Presentation: Prague, Czech
  • Year and Date: 2011-09-17
• [Presentation] The relationship between CCL-1 and neuron/glia in the neuropathic pain model (2011)
  • Author(s): Nozomi Akimoto, Kenji Honda, Yukio Takano, Mami Noda
  • Organizer: EuroGlia2011 (10^<th> European meeting on Glial cells in Health and Disease)
  • Place of Presentation: Prague, Czech
  • Year and Date: 2011-09-15
• [Presentation] Nicotine inhibits activation of microglial proton currents via interactions with α7 acetylcholine receptors (2011)
  • Author(s): Ai Kobayashi, Toshio Narahashi, Mami Noda
  • Organizer: EuroGlia2011 (10^<th> European meeting on Glial cells in Health and Disease)
  • Place of Presentation: Prague, Czech
  • Year and Date: 2011-09-13
• [Presentation] The molecular neurobiology of anti-oxidative stress induced by hydrogen (2011)
  • Author(s): Mami Noda, Kyota Fujita, Mizuho A.Kido, Yusaku Nakabeppu
  • Organizer: 7^<th> FAOPS (Federation of the Asian and Oceanian Physiological Society) Congress 2011
  • Place of Presentation: Taipei, Taiwan(招待講演)
  • Year and Date: 2011-09-12
• [Presentation] Neurotransmitter regulation of microglial motility and phagocytosis (2011)
  • Author(s): Mami Noda, Yuko Okuno, Masataka Ifuku
  • Organizer: Turkish FEPS (Federation of European Physiological Societies) Physiology Congress 2011
  • Place of Presentation: Istanbul (Yeditepe University), Turky(招待講演)
  • Year and Date: 2011-09-06
• [Presentation] CCL-1の疼痛発現との連関、および神経細胞-グリア細胞連関の解明 (2011)
  • Author(s): 秋元望, 野田百美
  • Organizer: 第21回日本病態生理学会
  • Place of Presentation: 日本大学医学部・東京
  • Year and Date: 2011-08-20
• [Presentation] ニコチンによるミクログリア活性化の抑制メカニズム解明と神経変性疾患への応用～創薬ターゲットとしてのα7ニコチン性アセチルコリン受容体～ (2011)
  • Author(s): 小林亜衣、楢橋敏夫、野田百美
  • Organizer: 九州大学大学院薬学研究院合同セミナー
  • Place of Presentation: 福岡
  • Year and Date: 2011-08-01
• [Presentation] Neuropeptide Receptors in Microglia and their Function (2011)
  • Author(s): Mami Noda
  • Organizer: Reflections in Neuroscience : Integration and disintegration in the brain (RINIDOB 2011)
  • Place of Presentation: Bilbao, Spain(招待講演)
  • Year and Date: 2011-06-13
• [Presentation] Microenvironment of metastasized tumor cells in the brain (2011)
  • Author(s): Noda M., Seike T., Fujita K., Iguchi H.
  • Organizer: III International Symposium "Interaction of nervous and immune systems in health and disease"
  • Place of Presentation: St.Petersburg, Russia(招待講演)
  • Year and Date: 2011-06-08
• [Presentation] Role of GluR2 Subunit of AMPA-type of Glutamate Receptor in Microglia (2011)
  • Author(s): Mami Noda
  • Organizer: NeuroTalk 2011
  • Place of Presentation: Dalian, China(招待講演)
  • Year and Date: 2011-05-24
• [Presentation] ミクログリアの機能に及ぼす甲状腺ホルモンの作用解明 (2011)
  • Author(s): 毛利優希、奥野祐子、藤田慶大、別府薫、秋元望、井福正隆、野田百美
  • Organizer: 第13回ブレインサイエンス研究会
  • Place of Presentation: 阿蘇、熊本
  • Year and Date: 2011-05-24
• [Presentation] MPTP誘発性パーキンソン病モデルにおける水素含有水飲水による神経保護作用 (2011)
  • Author(s): 井上芙美子、藤田慶大、山藤芽実、野田百美
  • Organizer: 第13回ブレインサイエンス研究会
  • Place of Presentation: 阿蘇、熊本
  • Year and Date: 2011-05-24
• [Presentation] Polyriboinosinic : polyribocytidylic acid (PolyI:C)誘導性慢性疲労症候群(CFS)発症メカニズムの解明 (2011)
  • Author(s): 大坪壮一、井福正隆、泉杏子、片渕俊彦、野田百美
  • Organizer: 第13回ブレインサイエンス研究会
  • Place of Presentation: 阿蘇、熊本
  • Year and Date: 2011-05-24
• [Presentation] ケトン体がミクログリアに与える影響 (2011)
  • Author(s): 直江智子、野田百美
  • Organizer: 第13回ブレインサイエンス研究会
  • Place of Presentation: 阿蘇、熊本
  • Year and Date: 2011-05-24
• [Presentation] Brain metastasis of lung cancer and microenvironment in the brain (2011)
  • Author(s): Mami Noda
  • Organizer: China-Japan symposium on cancer research
  • Place of Presentation: Shenzhen, China(招待講演)
  • Year and Date: 2011-05-20
• [Presentation] Interaction between lung cancer cells and glial cells in brain metastasis (2011)
  • Author(s): Mami Noda, Toshihiro Seike, Kyota Fujita, Soichi Takiguchi, Haruo Iguchi
  • Organizer: American Association for Canser Research, 102^<nd> Annual Meeting
  • Place of Presentation: Florida, USA(招待講演)
  • Year and Date: 2011-04-04
• [Presentation] Glutamate receptors in microglia and their loss of function in pathologic conditions. (2011)
  • Author(s): Mami Noda, Kaoru Beppu, Mizuho A.Kido, Rolf Sprengel.
  • Organizer: Gordon Research Conference on Glial Biology : Functional Interaction between Glia & Neuron.(2011)
  • Place of Presentation: Ventura, USA.
  • Year and Date: 2011-03-11
• [Presentation] Activation of microglia is important in polyinosinic-polycytidylic acid (poly I : C)-induced fatigue (2011)
  • Author(s): Masataka Ifuku, Kyoko Izumi, Soichi Otubo, Mami Noda, Toshihiko Katafuchi
  • Organizer: 日本病態生理学会若手セミナー
  • Place of Presentation: 神戸市
  • Year and Date: 2011-01-23
• [Presentation] Immunologically induced fatigue and glial cells. (2010)
  • Author(s): Toshihiko Katafuchi, Masataka Ifuku, Sachiko Take, Kyoko Izumi, Shoichi Otsubo, Mami Noda.
  • Organizer: The 9^<th> Japan-Korea Joint Symposium on Brain, Cardiac and Smooth Muscles.
  • Place of Presentation: Kagoshima, Japan
  • Year and Date: 2010-11-26
• [Presentation] Role of GluA2 (GluR-B) subunits of AMPA type of glutamate receptor in microglia. (2010)
  • Author(s): Mami Noda
  • Organizer: The 9^<th> Japan-Korea Joint Symposium on Brain, Cardiac and Smooth Muscles.
  • Place of Presentation: Kagoshima, Japan
  • Year and Date: 2010-11-26
• [Presentation] Physiological role of GluR2 subunits of AMPA type of Glutamate Recept or in Microglia and pathophysiological implication. (2010)
  • Author(s): Beppu K, Kosai Y, Kido MA, Shinagawa R, Shigemoto R, Sprengel R, Noda M.
  • Organizer: Society for Neuroscience, 40^<th> Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-17
• [Presentation] Activation of microglia is important in polyinosinic-polycytidylic acid (poly I : C)-induced fatigue. (2010)
  • Author(s): Ifuku M, Izumi K, Soichi Otubo, Naoe S, Noda M, Katafuchi T.
  • Organizer: Society for Neuroscience, 40^<th> Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-17
• [Presentation] Chemotactic cytokine ligand-1 (CCL-1) contributes to neuropathic pain in mice. (2010)
  • Author(s): Akimoto N, Honda K, Ushijima Y, Nakashima S, Noda M, Takano Y.
  • Organizer: Society for Neuroscience, 40^<th> Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-14
• [Presentation] 水素含有飲用水による神経変性抵抗性の獲得とその機序解明への挑戦 (2010)
  • Author(s): 藤田慶大、城戸瑞穂、田中喜典、中別府雄作、野田百美
  • Organizer: 日本機能水学会第9回学術大会
  • Place of Presentation: 滋賀県大津市
  • Year and Date: 2010-10-30
• [Presentation] ミクログリアにおけるH^+電流に対するニコチンの作用 (2010)
  • Author(s): 小林亜衣、別府薫、野田百美
  • Organizer: 第15回グリア研究会
  • Place of Presentation: 福岡市
  • Year and Date: 2010-10-23
• [Presentation] Chemotactic cytokine ligand-1(CCL-1)の疼痛発現および神経-グリアとの関わり (2010)
  • Author(s): 秋元望, 本多健治, 牛島悠一, 別府薫, 高野行夫, 野田百美
  • Organizer: 第60回西日本生理学会
  • Place of Presentation: 長崎市
  • Year and Date: 2010-10-15
• [Presentation] Molecular hydrogen as medical gas ; anti-oxidant and ROS-resistant effects in the nervous system. (2010)
  • Author(s): Mami Noda
  • Organizer: 2010 Taiwan-Japan Bilateral Symposium-Nanotech and Health care
  • Place of Presentation: Kaohsiung, Taiwan
  • Year and Date: 2010-09-23
• [Presentation] Chemotactic cytokine ligand-1 (CCL-1) contributes to neuropathic pain in mice. (2010)
  • Author(s): Akimoto N, Honda K, Ushijima Y, Nakashima S, Yukio Takano Y, Noda M
  • Organizer: 第53回日本神経化学会大会
  • Place of Presentation: 神戸市
  • Year and Date: 2010-09-03
• [Presentation] Involvement of glial cells in the development of fatigue (2010)
  • Author(s): Izumi K, Ifuku M, Otsubo S, Naoe S, Noda M.Katafuchi T
  • Organizer: 第53回日本神経化学会大会
  • Place of Presentation: 神戸市
  • Year and Date: 2010-09-02
• [Presentation] MPTP誘発性パーキンソニズムに対する水素分子の神経保護作用 (2010)
  • Author(s): 藤田慶大、清家稔博、湯通堂紀子、大野みずき、山田英孝、山口浩雄、作見邦彦、山川裕希子、城戸瑞穂、高木厚司、片渕俊彦、田中喜典、中別府雄作、野田百美
  • Organizer: 「包括型脳科学研究推進支援ネットワーク」夏のワークショップ
  • Place of Presentation: 札幌市
  • Year and Date: 2010-07-29
• [Presentation] Gas mediator hydrogen as a tool for protection of Parkinson's disease. (2010)
  • Author(s): Noda M., Fujita K., Seike T., Ohno M., Kido M.A., Katafuchi T., Nakabeppu Y.
  • Organizer: World Pharma2010
  • Place of Presentation: Copenhagen, Denmark
  • Year and Date: 2010-07-21
• [Presentation] Hydrogen gas has protective effects on animal model of Parkinson's disease (2010)
  • Author(s): Noda M., Fujita K., Seike T., Ohno M., Kido M.A., Katafuchi T., Nakabeppu Y.
  • Organizer: 7^<th> FENS Forum of European Neuroscience
  • Place of Presentation: Amsterdam, Netherlands
  • Year and Date: 2010-07-05
• [Presentation] Chemotactic cytokine ligand-1(CCL-1)と疼痛発現および神経-グリア関連に関する研究 (2010)
  • Author(s): 秋元望, 本多健治, 別府薫, 高野行夫, 野田百美
  • Organizer: 第7回薬学研究院若手研究者セミナー
  • Place of Presentation: 福岡市
  • Year and Date: 2010-07-05
• [Presentation] 疲労におけるミクログリアの役割 (2010)
  • Author(s): 井福正隆、泉杏子、大坪壮一、直江智子、野田百美、片渕俊
  • Organizer: 第6回日本疲労学会総会・学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-06-26
• [Presentation] 神経因性疼痛発現におけるChemotactic cytokine ligand-1(CCL-1)の関わり (2010)
  • Author(s): 秋元望, 本多健治, 牛島悠一, 中島茂人, 別府薫、野田百美, 高野行夫
  • Organizer: 第12回ブレインサイエンス研究会
  • Place of Presentation: 北九州市
  • Year and Date: 2010-05-29
• [Presentation] Brain's immune cells, microglia ; its biology and pathology (2010)
  • Author(s): Mami Noda
  • Organizer: 1^<st> Annual World Congress of Immunodiseases and Therapy
  • Place of Presentation: Beijing, China
  • Year and Date: 2010-05-16
• [Book] Adv Exp Med Biol. (2013)
  • Author(s): Noda M, Ifuku M, Mori Y, Verkhratsky A.
  • Total Pages: 6
  • Publisher: Calcium Influx Through Reversed NCX Controls Migration of Microglia.
• [Book] Adv Exp Med Biol. (2013)
  • Author(s): Verkhratsky A, Noda M, Parpura V, Kirischuk S.
  • Total Pages: 11
  • Publisher: Sodium fluxes and astroglial function.
• [Book] AROMA RESEARCH (2013)
  • Author(s): 野田 百美・吉岡 亨
  • Total Pages: 3
  • Publisher: 加齢（aging）のメカニズム
• [Book] AROMA RESEARCH (2013)
  • Author(s): 野田 百美・吉岡 亨
  • Total Pages: 4
  • Publisher: 生命の時を刻むCa振動
• [Book] Oxford University Press (2012)
  • Author(s): Mami Noda, Alexej Verkhratsky
  • Publisher: Physiology of microglia, HelmutKettenmann & Bruce Ransom (ed
• [Book] Diane Palmieri (ed), Springer (2012)
  • Author(s): Mami Noda
  • Publisher: The Brain Microenvironment. Brain and Central Nervous System Metasitasis, the Biological Basis and Clinical Considerations
• [Book] Yasunobu Okada (ed) (2012)
  • Author(s): Mami Noda
  • Publisher: Transporter Current Measurements Modern Patch Clamp Te chniques
• [Book] AROMA RESEARCH (2012)
  • Author(s): 野田 百美・吉岡 亨
  • Publisher: 毒を薬に変えるElkind回復則 (連載:スローエイジング工学と香りのサイエンスで創る新しい生命科学像 1)
• [Book] Modern Patch Clamp Techniques (2012)
  • Author(s): Mami Noda
  • Total Pages: 12
  • Publisher: Transporter Current Measurements.
• [Book] AROMA RESEARCH (2012)
  • Author(s): 野田 百美・吉岡 亨
  • Total Pages: 5
  • Publisher: 毒を薬に変えるElkind回復則
• [Book] AROMA RESEARCH (2012)
  • Author(s): 野田 百美・吉岡 亨
  • Total Pages: 4
  • Publisher: 精油の薬理作用
• [Book] AROMA RESEARCH (2012)
  • Author(s): 野田 百美・吉岡 亨
  • Total Pages: 3
  • Publisher: 細胞の中の結合水とプロトンの流れ
• [Book] スタンダード薬学シリーズ (2012)
  • Author(s): 野田百美
  • Total Pages: 12
  • Publisher: 神経・筋の疾患
• [Book] Michael Bader (ed), Elsevier (2011)
  • Author(s): Mami Noda
  • Publisher: Chapter 6. Kallikrein-kinin system in the brain. Kinin book
• [Book] 最新パッチクランプ実験技術法 (2011)
  • Author(s): 野田 百美
  • Publisher: 吉岡書店
• [Book] 最新パッチクランプ実験技術法、13章トランスポータ電流記録・解析法 (2011)
  • Author(s): 野田百美
  • Total Pages: 6
  • Publisher: 吉岡書店
• [Book] Kinin book, 6 Kallikrein-kinin system in the brain (2011)
  • Author(s): Mami Noda
  • Total Pages: 17
  • Publisher: Elsevier
• [Book] (Glial Cells in Brain Defence Mechanisms.) NeuroImmune Biology.Vol.9 (2010)
  • Author(s): Mami Noda
  • Publisher: Elsevier
• [Book] AROMA RESEARCH
  • Author(s): 野田 百美・吉岡 亨
  • Publisher: 精油の薬理作用(連載:スローエイジング工学と香りのサイエンスで創る新しい生命科学像1)
• [Remarks] 研究室ホームページ Discover Magazine
  • URL: http://seiri.phar.kyushu-u.ac.jp/
• [Remarks] 掲載記事
  • URL: http://discovermagazine.com/2013/march/6-water-cure-stroke
• [Remarks] 病態生理学分野 業績
  • URL: http://seiri.phar.kyushu-u.ac.jp/
• [Remarks]
  • URL: http://seiri.phar.kyushu-u.ac.jp/
• [Remarks]
  • URL: http://seiri.phar.kyushu-u.ac.jp/