Molecular mechanism of neuroprotection by molecular
| Project/Area Number |
22590084
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyushu University |
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Principal Investigator |
NODA Mami 九州大学, 薬学研究院, 准教授 (80127985)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 酸化ストレス / 神経保護 / パーキンソン病 / 神経生物学 / 水素分子 / 神経疾患 / 抗酸化作用 / 消化管ホルモン / グレリン / 予防医学 / 視神経障害 / 虚血 |
|---|
| Research Abstract |
We showed that low concentration of molecular hydrogen (0.008 ppm) in drinkingwater had neuroprotective effects in Parkinson’s Disease model mice (Fujita et al., 2009). However, not only acute anti-oxidative effect but also upregulation of chaperone, heat shock protein (Hsp) 72, and involvement of gastric hormone, ghrelin, was suggested. These results will contribute to a preventive medicine which may be inducedby drinking hydrogen water.
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Report
(4 results)
Research Products
(103 results)
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[Journal Article] A kavalactone derivative inhibits lipopolysaccharide-stimulated iNOS induction and NO production through activation of Nrf2 signaling in BV2 microglial cells2013
Author(s)
Terazawa R, Akimoto N, Kat o T, I t o h T, Fujita Y, Hamada N, Deguchi T, Iinuma M, Noda M, Nozawa Y, Ito M
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Journal Title
Pharmacol Res
Volume: 71
Pages: 34-43
DOI
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Peer Reviewed
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[Journal Article] IL-6 Receptor Is a Possible Target against Growth ofMetastasized Lung Tumor Cells in the Brain2012
Author(s)
Noda M, Yamakawa Y, Matsunaga N, Naoe S, Jodoi T, Yamafuji M, AkimotoNoda M, Yamakawa Y, Matsunaga N, Naoe S, Jodoi T, Yamafuji M, Akimoto
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Journal Title
Int J Mol Sci
Volume: 14(1)
Issue: 1
Pages: 515-26
DOI
Related Report
Peer Reviewed
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[Presentation] Molecular hydrogen protects against central nervous system white matter ischemic injury.2012
Author(s)
Mami Noda, Kyota Fujita, Margaret A. Hamner, Megumi Yamafuji, Nozomi Akimoto, Mizuho A. Kido, Yoshinori Tanaka, Yusaku Nakabeppu, Bruce R. Ransom
Organizer
Society for Neuroscience, 42nd Annual Meeting
Place of Presentation
New Orleans, USA
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[Book] Adv Exp Med Biol.2013
Author(s)
Noda M, Ifuku M, Mori Y, Verkhratsky A.
Total Pages
6
Publisher
Calcium Influx Through Reversed NCX Controls Migration of Microglia.
Related Report
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[Book] Adv Exp Med Biol.2013
Author(s)
Verkhratsky A, Noda M, Parpura V, Kirischuk S.
Total Pages
11
Publisher
Sodium fluxes and astroglial function.
Related Report
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