Regulation of hippocampal neurogenesis by the amygdala

Research Project

Project/Area Number	22590089
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Biological pharmacy
Research Institution	Musashino University
Principal Investigator	ABE Kazuho 武蔵野大学, 薬学研究所, 教授 (60202660)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	海馬 / 神経新生 / 扁桃体 / アルツハイマー病 / 神経幹細胞
Research Abstract	The present study investigated whether the amygdala plays a role in regulation of neurogenesis in the hippocampus. Transection of the fimbria-fornix in the rat resulted in an increase of the number of neural stem cells (bromodeoxyuridine-positive cells) in the dentate gyrus. Lesion of the amygdala in the rat resulted in a decrease of the number of neural stem cells in the dentate gyrus. These results suggest that hippocampal neurogenesis is regulated by the amygdala.