Study on predictive factors for chemotherapy-associated neutropenia in outpatients treated with paclitaxel

• Project/Area Number: 22590138
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: University of Shizuoka
• Principal Investigator: KAGAWA Yoshiyuki 静岡県立大学, 薬学部, 教授 (90397505)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: がん化学療法 / パクリタキセル / 好中球減少症

Research Abstract

The aim of this study was to identify predictive risk factors for developing neutropenia after chemotherapy with paclitaxel. We successfully developed a new quantitative method for determination of blood paclitaxel concentration using LC-MS/MS. In clinical study, the wide interindividual variation in molar ratios of plasma 6α-hydroxypaclitaxel/ paclitaxel concentration was seen. More patients are, however, needed to identify predictive risk factors with paclitaxel-based chemotherapy.

Research Products

• [Journal Article] Influence of the Slow Infusion of a Soybean Oil Emulsion on Plasma Cytokines and Ex Vivo T Cell Proliferation After an Esophagectomy. (2013)
  • Author(s): Yoshiyuki Kagawa, Toshio Maeda, Yasuhiro Kato, Iori Ueda, Tomoko Kudo, Naoe Watanabe, Midori Kimura, Sato Minami, Tatsuichiro Sakamoto, Hiroshi Yamada, Masakazu Takagi.
  • Journal Title: JPEN J Parenter Enteral Nutr Volume: 37(1) Issue: 1 Pages: 123-8
  • DOI: 10.1177/0148607112442216
  • Peer Reviewed
• [Journal Article] Cytochrome P450 2C9 (CYP2C9) 及びCytochrome P450 2C19 (CYP2C19) のSingle Nuceotide Polymorphism (SNP) 迅速測定法の開発と小児てんかん患者への臨床応用 (2011)
  • Author(s): 山本吉章,高橋幸利,西村成子,幾見泰洋,三島信行,賀川義之
  • Journal Title: 薬学雑誌(YAKUGAKU ZASSHI) Volume: 131(5) Pages: 809-815
  • URL: http://dx.doi.org/10.1248/yakushi.131.809
  • Peer Reviewed
• [Presentation] クロバザムおよびN-デスメチルクロバザムの薬物動態に影響を与える因子の検討 (2012)
  • Author(s): 山本吉章、宮川紘、高橋幸利、今井克美、松田和己、井上有史、賀川義之
  • Organizer: 第22回日本医療薬学会年会要旨集、p443
  • Place of Presentation: 新潟
  • Year and Date: 2012-10-28
• [Presentation] ラモトリギンの血中濃度に影響を及ぼす抗てんかん薬の検討 (2011)
  • Author(s): 山本吉章、松田一己、高橋幸利、井上有史、賀川義之
  • Organizer: 第21回日本医療薬学会年会要旨集、p329
  • Place of Presentation: 神戸
  • Year and Date: 2011-10-01
• [Presentation] クロバザムおよびN-デスメチルクロバザムの薬物動態に影響を与える因子の検討
  • Author(s): 山本吉章
  • Organizer: 日本医療薬学会年会
  • Place of Presentation: 新潟市
• [Book] Visual Core Pharma 薬物治療学改訂2版 (2013)
  • Author(s): 賀川義之他編(分担執筆)
  • Publisher: 南山堂
• [Book] Visual Core Pharma 薬物治療学 改訂2版 (2013)
  • Author(s): 吉尾隆
  • Total Pages: 760
  • Publisher: 南山堂
• [Book] 病気と薬パーフェクトブック2012 (2012)
  • Author(s): 賀川義之他著(分担執筆)
  • Publisher: 南山堂
• [Book] 病気と薬 パーフェクトBOOK 2012 (2012)
  • Author(s): 横田千津子
  • Total Pages: 1595
  • Publisher: 南山堂